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GRASP encodes a protein that functions as a molecular scaffold, linking receptors, including group 1 metabotropic glutamate receptors, to neuronal proteins. Additionally we are shipping GRASP Antibodies (35) and many more products for this protein.
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Study results indicate a potential role of Grasp in the p53 (show TP53 Proteins)-mediated response of skin to UVB exposure
A major mechanism by which insulin (show INS Proteins) regulates glut4 (show SLC2A4 Proteins) recycling was uncovered. A general receptor for 3-phosphoinositides 1 was identified as a guanine nucleotide exchange factor for ADP-ribosylation factor 6 (show PSD3 Proteins) that promotes glut4 (show SLC2A4 Proteins) vesicle formation.
An upregulation of scaffold protein (show HOMER1 Proteins) tamalin is found selectively in the hippocampus of animals subjected to electroconvulsive shock.
Caspase (show CASP3 Proteins) cleavage of GRASP-1 (show GRIPAP1 Proteins) occurs in specific brain regions in a time-dependent manner during development and ischemia.
tamalin is a novel signaling molecule that possesses a PDZ domain and a PDZ binding motif and mediates Syk (show SYK Proteins) signaling in an ITAM-based fashion
plays a role in metabotropic glutamate (show GRIN1 Proteins) receptor transport and forms its autoinhibitory state.[review]
Schizophrenia subjects compared to controls showed a marked increase in CA1 (show CA1 Proteins) hippocampal Norbin (show NCDN Proteins), and Tamalin proteins (47% and 34% respectively), which are endogenous regulators of mGluR5 (show GRM5 Proteins) signalling and trafficking
GRASP bridges the guanine nucleotide exchange factors (GEFs) that activate Arf and Rac (show AKT1 Proteins), thereby promoting Arf-to-Rac (show AKT1 Proteins) signaling By binding to both cytohesin 2/ARNO (show CYTH2 Proteins) and Dock180 (show DOCK1 Proteins).
GRASP regulates the non-clathrin/Arf6 (show ARF6 Proteins)-dependent, plasma membrane recycling and signalling pathways.
protein-protein interaction mediated by ARNO (show CYTH2 Proteins) coiled-coil domain required for ARNO (show CYTH2 Proteins) induced motility; coiled-coil domain promotes assembly of multiprotein complex containing ARNO (show CYTH2 Proteins) and Dock180 (show DOCK1 Proteins); assembly of complex requires coiled-coil domain, GRASP and IPCEF
The crystal structures of the autoinhibitory PDZ domain of Tamalin has implications for the regulation of metabotropic glutamate (show GRIN1 Proteins) receptor trafficking.
This gene encodes a protein that functions as a molecular scaffold, linking receptors, including group 1 metabotropic glutamate receptors, to neuronal proteins. The encoded protein contains conserved domains, including a leucine zipper sequence, PDZ domain and a C-terminal PDZ-binding motif. Alternately spliced transcript variants have been observed for this gene.
general receptor for phosphoinositides 1-associated scaffold protein
, GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein
, GRP1-associated scaffold protein
, 95 kDa postsynaptic density protein discs-large ZO-1 domain-containing protein
, Grp1 (general receptor for phosphoinositides)-associated scaffold protein
, PSD-95 PDZ domain-containing protein