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GJD2 is a member of the connexin gene family that is expressed predominantly in mammalian neurons. Additionally we are shipping Gap Junction Protein, delta 2, 36kDa Proteins (3) and many more products for this protein.
Showing 10 out of 60 products:
Human Polyclonal GJD2 Primary Antibody for EIA, IHC (p) - ABIN357101
de Brouwer, Pennings, Roeters, Van Hauwe, Astuto, Hoefsloot, Huygen, van den Helm, Deutman, Bork, Kimberling, Cremers, Cremers, Kremer: Mutations in the calcium-binding motifs of CDH23 and the 35delG mutation in GJB2 cause hearing loss in one family. in Human genetics 2003
Show all 2 references for ABIN357101
Chicken Polyclonal GJD2 Primary Antibody for IHC, WB - ABIN2774866
Charpantier, Cancela, Meda: Beta cells preferentially exchange cationic molecules via connexin 36 gap junction channels. in Diabetologia 2007
Cow (Bovine) Polyclonal GJD2 Primary Antibody for WB - ABIN2774908
Degen, Meier, Van Der Giessen, Söhl, Petrasch-Parwez, Urschel, Dermietzel, Schilling, De Zeeuw, Willecke: Expression pattern of lacZ reporter gene representing connexin36 in transgenic mice. in The Journal of comparative neurology 2004
The results suggest that electrical synapses formed by Cx36-containing gap junctions occur in most of the widely distributed centers of the auditory system.
The resilts of this study showed that the phosphorylation state of Cx36 as a key biochemical step at the crossroad of light-dark and circadian regulatory pathways that control photoreceptor coupling.
The magnitudes of the 2f1 (show KLRG1 Antibodies)-f2 distortion products were not different between Cx36 knockout and wild-type mice, suggesting similar cochlear function in the two groups
Mg(2 (show MCOLN1 Antibodies)+)-dependent synaptic plasticity of Cx36-containing electrical synapses could underlie neuronal circuit reconfiguration via changes in brain energy metabolism that affects neuronal levels of intracellular ATP and [Mg(2 (show MCOLN1 Antibodies)+)]i.
Gene expression data indicate that EPCs, or their soluble products, modulate the expression of the beta-cell surface molecule connexin 36 and affect glucose-stimulated insulin (show INS Antibodies) release in vitro.
Some neurons exhibit at least two discriminatory mechanisms for assembling Cx36 into gap junctions.
The Cx36 was expressed in the mouse carotid body and in the intestine at ileum and colon level.
The results indicate the presence of Cx36-containing gap junctions in the sexually dimorphic dorsomedial nucleus and dorsolateral nucleus of both male and female rodents
The genetic deletion of the GJ subunit Cx36 increased cell survivability by approximately 50% under excitotoxic condition.
Data (including data from studies in knockout mice) suggest that Cx36/Gjd2 gap junction channels are necessary for full up-regulation of insulin (show INS Antibodies) secretion by islet cells; mice with defective Cx36/Gjd2 expression exhibit glucose intolerance.
It was shown that the decreased level of the examined neuronal proteins was accompanied by the impaired coexpression of synaptophysin (show SYP Antibodies)/neurofilaments and Cx36 in the series of astrocytomas--anaplastic astrocytomas--glioblastomas.
In this study, there was no association of the analyzed SNPs located in RASGRF1 (show RASGRF1 Antibodies). GJD2, and ACTC1 (show ACTC1 Antibodies) with pathological myopia.
Three SNP alleles in BRD2 (show BRD2 Antibodies), Cx-36, and ME2 (show CELSR1 Antibodies) and microdeletions in 15q13.3, 15q11.2, and 16p13.11 also contribute risk to juvenile myclonic epilepsy.
Cx36 GJs are highly cation-selective and should exhibit relatively low permeability to numerous vital negatively charged metabolites and high permeability to potassium ion, a major charge carrier in cell-cell communication.
A polymorphism of Cx36 gene is associated to certain forms of human diabetes
connexin genes Gjd2 coding for mCx36, Gjc1 (show GJC1 Antibodies) coding for mCx45 and Gja10 (show GJA9 Antibodies) coding for mCx57 in the mouse, a subset of 4 connexin genes, including the unique GJA9 (Cx59 (show GJA9 Antibodies)) and GJA10 (Cx62 (show GJa10 Antibodies)), could be detected at least as transcript isoforms in the human retina.
Variations in GJD2 is associated with refractive errors and myopia.
Mutations in the calcium-binding motifs of CDH23 (show CDH23 Antibodies) and the 35delG mutation in GJB2 (show GJB2 Antibodies) cause hearing loss in one family
connexin 36 expression is regulated by the transcriptional repressor NRSF (show REST Antibodies)/REST
35delG mutation of the GJB2 (show GJB2 Antibodies) gne (show GNE Antibodies) is a risk for deafness
Interneuronal communication at gap junctions made by connexin 36 may not be regulated by direct phosphorylation of connexin 36, but possibly by phosphorylation of associated proteins.
This gene encodes a member of the connexin protein family. Connexins are gap junction proteins which are arranged in groups of 6 around a central pore to form a connexon, a component of the gap junction intercellular channel. The channels formed by this protein allow cationic molecule exchange between human beta cells and may function in the regulation of insulin secretion.
, gap junction protein, alpha 9, 36kDa
, gap junction protein, delta 2, 36kDa
, gap junction delta-2 protein
, gap junction protein, alpha 9, 59kDa
, gap junction protein, alpha 10, 62kDa
, gap junction alpha-10 protein-like
, gap junction alpha-9 protein-like
, gap junction alpha-9 protein
, gap junction membrane channel protein alpha 9
, gap junction protein, alpha 9
, connexin 36
, connexin 35.1
, gap junction channel-forming protein