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anti-Gephyrin (GPHN) Antibodies

GPHN encodes a neuronal assembly protein that anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton via high affinity binding to a receptor subunit domain and tubulin dimers. Additionally we are shipping Gephyrin Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GPHN 10243 Q9NQX3
GPHN 268566 Q8BUV3
GPHN 64845 Q03555
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Top anti-Gephyrin Antibodies at antibodies-online.com

Showing 10 out of 77 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated FACS, IHC (p), WB GPHN Antibody (Center) flow cytometric analysis of MCF-7 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. GPHN Antibody (Center) IHC analysis in formalin fixed and paraffin embedded brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the GPHN Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Chicken Mouse Un-conjugated IF, IP, IHC, WB Western blot analysis of Gephyrin on rat brain lysate. Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of anti-Gephyrin. Rat cerebellum, formalin-fixed paraffin embedded tissue, with citrate pre-treatment, 20X. 50 μg Log in to see 5 to 6 Days
$205.42
Details
Chicken Mouse Un-conjugated IF, IP, IHC, WB Western blot analysis of Gephyrin. Lysates from rat cerebrum (5 µg/lane), S2 cells (7.5 µg/lane), and 0-12 hours Drosophila embryos (7.5 µg/lane) were probed with anti- Gephyrin at concentrations of 4 µg/ml (lane 1), 2 µg/ml (lane 2), and 1 µg/ml (lane 3). Anti-Gephyrin detects a band of 93 kDa in rat cerebrum and 74 kDa in S2 cells and Drosophila embryos. Gephyrin immunochemical staining of 0-12 hour embryos. Formalin-fixed embryos kept in ethanol at -20°C, were re-hydrated and incubated with anti-Gephyrin at 1 µgg/ml in TBST. After extensive washes to remove unbound antibody, Gephyrin signal was visualized with ALEXA fluor 488 secondary antibody (1/300) and confocal microscopy. Gephyrin staining is found throughout the cellularizing embryo, and it appears more intense in the nuclei with nuclear dots stained. 50 μg Log in to see 5 to 6 Days
$205.42
Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-GPHN Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-GPHN Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: 721_B cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB GPHN Antibody (Center) (ABIN653742) western blot analysis in MCF-7,Hela,NCI-H460,HepG2 cell line and mouse liver tissue lysates (35 µg/lane).This demonstrates the GPHN antibody detected the GPHN protein (arrow). GPHN Antibody (Center) (ABIN653742) IHC analysis in formalin fixed and paraffin embedded brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated FACS, IF, WB HEK293T cells transfected with either RC205986 overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-GPHN antibody (ABIN2454074), and then analyzed by flow cytometry. Anti-GPHN mouse monoclonal antibody (ABIN2454074) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY GPHN (RC205986). 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Mouse Un-conjugated IF, WB Anti-GPHN mouse monoclonal antibody (ABIN2454076) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY GPHN (RC205986). HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY GPHN (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-GPHN. 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Mouse Un-conjugated FACS, IHC, WB HEK293T cells transfected with either RC205986 overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-GPHN antibody (ABIN2454095), and then analyzed by flow cytometry. HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY GPHN (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-GPHN. 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Mouse Un-conjugated FACS, WB HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY GPHN (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-GPHN. 100 μL Log in to see 2 to 3 Days
$423.50
Details

GPHN Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Gephyrin Antibodies

  1. Chicken Monoclonal Gephyrin Primary Antibody for IF, IP - ABIN968050 : Feng, Tintrup, Kirsch, Nichol, Kuhse, Betz, Sanes: Dual requirement for gephyrin in glycine receptor clustering and molybdoenzyme activity. in Science (New York, N.Y.) 1998 (PubMed)
    Show all 4 references for ABIN968050

  2. Human Polyclonal Gephyrin Primary Antibody for FACS, IHC (p) - ABIN952493 : Inada, Koga, Ishiguro, Horiuchi, Syu, Yoshio, Takahashi, Ozaki, Arinami: Pathway-based association analysis of genome-wide screening data suggest that genes associated with the gamma-aminobutyric acid receptor signaling pathway are involved in neuroleptic-induced, treatment-resistant tardive dyskinesia. in Pharmacogenetics and genomics 2008 (PubMed)
    Show all 2 references for ABIN952493

  3. Chicken Monoclonal Gephyrin Primary Antibody for IF, IP - ABIN968898 : Meyer, Kirsch, Betz, Langosch: Identification of a gephyrin binding motif on the glycine receptor beta subunit. in Neuron 1995 (PubMed)
    Show all 2 references for ABIN968898

More Antibodies against Gephyrin Interaction Partners

Zebrafish Gephyrin (GPHN) interaction partners

  1. duplicated gephyrin genes mediate Moco biosynthesis and control postsynaptic clustering of glycine receptor (show GLRB Antibodies)

Human Gephyrin (GPHN) interaction partners

  1. A missense mutation of gephyrin that was unable to synthesize MoCo and activate MoCo-dependent enzymes was identified.

  2. A yin-yang haplotype pattern encompassing gephyrin consists of 284 divergent nucleotide states and both variants vary drastically from their mutual ancestral haplotype, suggesting rapid evolution.

  3. The N-terminal region of GABRA3 (show GABRA3 Antibodies) and the GlyR beta subunit (show POLG Antibodies) occupies the same binding site of gephyrin.

  4. Results show that PKC (show PRRT2 Antibodies)-dependent phosphorylation of GAP43 (show GAP43 Antibodies) plays a critical role in regulating postsynaptic gephyrin aggregation in developing GABAergic synapses.

  5. Structural exonic microdeletions affecting the GPHN gene constitute a rare genetic risk factor for IGE and other neuropsychiatric disorders by an impairment of the GABAergic inhibitory synaptic transmission.

  6. The enhancement of Cb-induced gephyrin clustering by GTP (show AK3 Antibodies)-TC10 (show RHOQ Antibodies) does not depend on the guanine nucleotide exchange activity of Cb but involves an interaction that resembles reported interactions of other small GTPases with their effectors

  7. abnormal accumulations of gephyrin are highly correlated with the neuropathologic diagnosis of Alzheimer disease in 17 AD versus 14 control cases. Furthermore, gephyrin accumulations were specific for AD.

  8. Rare exonic deletions implicate the synaptic organizer Gephyrin (GPHN) in risk for autism, schizophrenia and seizures.

  9. Extracellular signal-regulated kinase and glycogen synthase kinase 3beta regulate gephyrin postsynaptic aggregation and GABAergic synaptic function in a calpain-dependent mechanism

  10. A reduction in the number of gephyrin clusters in primary neurons reduces GABA signaling.

Mouse (Murine) Gephyrin (GPHN) interaction partners

  1. adult mice lacking interleukin-1 receptor 1 (show IL1RL1 Antibodies) (IL-1R1) exhibit increased expression of both the excitatory scaffolding protein postsynaptic density-95 (PSD-95 (show DLGAP2 Antibodies)) and inhibitory scaffolding proteingephyrin, respectively, in the hippocampus.

  2. The results demonstrate that formation of GABAergic synapses containing a postsynaptic gephyrin scaffold is crucial for morphological differentiation, synaptic integration, and long-term survival of adult-born granule cells/

  3. Data suggest that KIF5 (show KIF5A Antibodies) regulates gephyrin sorting by a mechanism that involves GSK3 (show GSK3b Antibodies) activity.

  4. Pin1 (show PIN1 Antibodies)-dependent signaling represents a mechanism to modulate GABAergic transmission by regulating NL2 (show MMEL1 Antibodies)/gephyrin interaction.

  5. These results reveal a homeostatic mechanism through which activity regulates the dynamics and function of perisomatic inhibitory synapses, and they identify a CaMKII (show CAMK2G Antibodies)-dependent phosphorylation site on gephyrin.

  6. study reveals that palmitoylation of gephyrin by DHHC-12 contributes to dynamic and functional modulation of GABAergic synapses

  7. Within this network, collybistin (show Arhgef9 Antibodies) can adopt open/active and closed/inactive conformations to act as a switchable adaptor that links gephyrin to plasma membrane phosphoinositides.

  8. these findings suggest that gephyrin may be a key factor in BDNF (show BDNF Antibodies)-dependent GABAAR (show GABRG2 Antibodies) regulation in the amygdala.

  9. Data suggest that the loss of neurotransmitter receptor (show GRIN1 Antibodies) clustering at inhibitory synapses causes the early lethality of gephyrin deficient mice.

  10. Gephyrin is critical for glycine receptor (show GLRB Antibodies) clustering in hippocampal neurons.

Gephyrin (GPHN) Antigen Profile

Protein Summary

This gene encodes a neuronal assembly protein that anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton via high affinity binding to a receptor subunit domain and tubulin dimers. In nonneuronal tissues, the encoded protein is also required for molybdenum cofactor biosynthesis. Mutations in this gene may be associated with the neurological condition hyperplexia and also lead to molybdenum cofactor deficiency. Numerous alternatively spliced transcript variants encoding different isoforms have been described\; however, the full-length nature of all transcript variants is not currently known.

Gene names and symbols associated with anti-Gephyrin (GPHN) Antibodies

  • gephyrin (GPHN) antibody
  • gephyrin a (gphna) antibody
  • gephyrin (PTRG_08978) antibody
  • gephyrin (VDBG_00775) antibody
  • gephyrin (Tsp_03043) antibody
  • gephyrin (gphn) antibody
  • gephyrin (Gphn) antibody
  • 5730552E08Rik antibody
  • AI662856 antibody
  • BC027112 antibody
  • C230040D23 antibody
  • DKFZp459M0825 antibody
  • Geph antibody
  • gpgb1 antibody
  • GPH antibody
  • GPHN antibody
  • GPHRYN antibody
  • HKPX1 antibody

Protein level used designations for anti-Gephyrin (GPHN) Antibodies

gephyrin , gephyrin1 , gephyrin-like , gephyrin isoform , putative glycine receptor-tubulin linker protein

GENE ID SPECIES
100063078 Equus caballus
709677 Macaca mulatta
452976 Pan troglodytes
555470 Danio rerio
6347264 Pyrenophora tritici-repentis Pt-1C-BFP
9530667 Verticillium alfalfae VaMs.102
10900320 Trichinella spiralis
100022949 Monodelphis domestica
100124966 Xenopus (Silurana) tropicalis
100172899 Pongo abelii
100331181 Danio rerio
100396072 Callithrix jacchus
100471953 Ailuropoda melanoleuca
100555683 Anolis carolinensis
779372 Xenopus laevis
428878 Gallus gallus
10243 Homo sapiens
490739 Canis lupus familiaris
535194 Bos taurus
268566 Mus musculus
64845 Rattus norvegicus
100153443 Sus scrofa
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