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Glutamate Receptor, Metabotropic 8 Proteins (GRM8)

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Additionally we are shipping GRM8 Antibodies (83) and GRM8 Kits (18) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GRM8 2918 O00222
GRM8 14823  
Rat GRM8 GRM8 60590 P70579
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Top GRM8 Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Wheat germ Human Un-conjugated   10 μg Log in to see 9 Days
$641.43
Details

GRM8 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
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More Proteins for Glutamate Receptor, Metabotropic 8 (GRM8) Interaction Partners

Human Glutamate Receptor, Metabotropic 8 (GRM8) interaction partners

  1. Study represents a genetic association test towards single variant and multi-markers interaction of GRM7 and GRM8 genes in both schizophrenia and major depressive disorders in Han Chinese population

  2. These results further implicate the role of glutamate (show GRIN1 Proteins) receptor genes such as GRM8 in the development of alcohol dependence.

  3. Genome wide association study and meta-analysis results detected rs6951643, a GRM8 genetic variant as suggestive marker for sporadic Creutzfeldt-Jakob disease risk mapping outside the PRNP (show PRNP Proteins) region.

  4. propose three potential human candidate genes for voluntary physical exercise levels (MC3R (show MC3R Proteins), CYP24A1 (show CYP24A1 Proteins), and GRM8).

  5. The GRM8 gene might play an important role in the pathogenesis of schizophrenia.

  6. Glutamate (show GRIN1 Proteins) acts as a partial inverse agonist to metabotropic glutamate (show GRIN1 Proteins) receptor with a single amino acid mutation in the transmembrane domain

  7. Eight suggestive significant loci were detected with a series of genes expressed within the inner ear that underlie the auditory function, such as: DCLK1 (show DCLK1 Proteins), PTPRD (show PTPRD Proteins), GRM8, CMIP (show CMIP Proteins).

  8. Pias1 (show PIAS1 Proteins) binds to and sumoylates metabotropic glutamate receptor 8

  9. GRM8 genes are likely involved in the pathogenesis of autistic disorder.

  10. Association of suingle nucleotide polymorphisms in GRM8 with theta power of event-related oscillations and alcohol dependence are reported.

Mouse (Murine) Glutamate Receptor, Metabotropic 8 (GRM8) interaction partners

  1. the data of this study revealed very different roles for mGlu8 in amygdala synaptic transmission, fear learning and its expression

  2. In the dentate gyrus of mGluR8 receptor-deficient mice, effects from selective agonists are linked to the lateral and medial perforant pathway.

  3. mGluR8 is an important regulator of excitatory transmission in the bed nucleus of the stria terminalis, and is selectively disrupted by both acute and chronic stress.

  4. mGluR8 deficiency decreased measures of anxiety in the elevated plus maze and the acoustic startle response in female mice.

  5. Might be potential target for disorders with pathophysiological changes in brain areas where mGlu8 modulates glutamate (show GRIN1 Proteins) and GABA transmission, especially in anxiety disorders involving exaggerated contextual fear.

  6. The role of mGluR8 as a presynaptic autoreceptor and its contribution to cognitive processes are hypothesized and the utility of gene targeting is discussed as compared to pharmacological methods.

  7. Naive mGlu8 receptor-deficient mice show increased anxiety-related behavior in the elevated plus maze in low illumination conditions (red light) compared to wild-type mice.

  8. The increased anxiety-related behavior of mGlu8 receptor knockout mice in the elevated plus maze is associated with an increased number of c-Fos positive cells in the centromedial nucleus of the thalamus compared with wild-type mice.

  9. Increased measures of anxiety and weight gain in mice lacking the group III metabotropic glutamate (show GRIN1 Proteins) receptor mGluR8.

  10. mGluR8 was localized in two broad bands, one each in the OFF and ON layers of the IPL (show PHLDA2 Proteins); mGluR8 immunoreactivity was evident in the OFF plexus of cholinergic amacrine cell processes

GRM8 Protein Profile

Protein Summary

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with GRM8

  • glutamate receptor, metabotropic 8 (GRM8)
  • metabotropic glutamate receptor 8 (MGLUR8)
  • metabotropic glutamate receptor 8 (LOAG_14062)
  • glutamate receptor, metabotropic 8 (Grm8)
  • A230002O04 protein
  • Glur8 protein
  • Gprc1h protein
  • GRM8 protein
  • mGlu8 protein
  • mGlur protein
  • Mglur8 protein
  • mGluR8b protein

Protein level used designations for GRM8

metabotropic glutamate receptor 8 , metabotropic type glutamate receptor 8 , glutamate receptor, metabotropic 8 , G protein coupled receptor, family C, group 1, member H , G protein-coupled receptor, family C, group 1, member H , G protein-coupled receptor family C group 1 member H , metabotropic glutamate receptor subtype 8b

GENE ID SPECIES
538360 Bos taurus
751963 Taeniopygia guttata
100137389 Papio anubis
443293 Ovis aries
9951540 Loa loa
2918 Homo sapiens
14823 Mus musculus
60590 Rattus norvegicus
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