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Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis.. Additionally we are shipping GPAT2 Antibodies (18) and many more products for this protein.
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GPAT2 as a cancer testis gene
Data suggest that Gpat2 is necessary for normal spermatogenesis; absence of Gpat2 up-regulates expression of apoptosis regulatory proteins, triggers apoptosis, and thereby decreases the number of dividing germ cells; Gpat2 knockdown (using RNA silencing) prevents germ cells from proceeding through pachytene stage.
Thus, Gpat2 is expressed at a specific stage of spermatogenesis, consistent with piRNA synthesis and meiosis I prophase
GPAT2 is essential for the biogenesis of piRNA.
GPAT2 expression is linked to arachidonoyl-CoA incorporation into TAG in spermatogenic germ cells
These results suggest that the GPAT2 protein has two transmembrane segments and that the N-terminal and C-terminal regions of this protein face (show FANCE Proteins) the cytoplasm.
A novel murine glycerol-3-phosphate acyltransferase-like protein 1 (named xGPAT1) has been cloned.
Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis.
, cancer/testis antigen 123
, glycerol-3-phosphate acyltransferase-like 1