Glyoxalase I Proteins (GLO1)

The enzyme encoded by GLO1 is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione. Additionally we are shipping Glyoxalase I Antibodies (113) and Glyoxalase I Kits (26) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GLO1 109801 Q9CPU0
Rat GLO1 GLO1 294320 Q6P7Q4
GLO1 2739 Q04760
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Top Glyoxalase I Proteins at antibodies-online.com

Showing 10 out of 25 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 2 to 3 Days
$270.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 15 to 19 Days
$242.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 20 to 21 Days
$437.80
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 15 to 18 Days
$717.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
Yeast Macaca fascicularis His tag   1 mg Log in to see 60 to 71 Days
$2,432.83
Details
Yeast Rice His tag   1 mg Log in to see 60 to 71 Days
$2,768.33
Details

GLO1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
, ,

Top referenced Glyoxalase I Proteins

  1. Human GLO1 Protein expressed in Escherichia coli (E. coli) - ABIN666885 : Ridderström, Mannervik: Optimized heterologous expression of the human zinc enzyme glyoxalase I. in The Biochemical journal 1996 (PubMed)
    Show all 2 references for 666885

More Proteins for Glyoxalase I (GLO1) Interaction Partners

Mouse (Murine) Glyoxalase I (GLO1) interaction partners

  1. These data indicate that Glo1 knockout reduces anxiety-like behavior, but increases depression-like behavior.

  2. Alternative detoxification of methylglyoxal in GLO1(-/-) is achieved by increased catalytic efficiency of aldose reductase (show AKR1B1 Proteins) toward hemithioacetal (product of glutathione and methylglyoxal ), which is most likely caused by S-nitrosylation of aldose reductase (show AKR1B1 Proteins).

  3. Glo1 knockdown does not have major short term effects on the energy expenditure or the formation of atherosclerotic plaques.

  4. Crystal structure of the mouse Glo1-inhibitor complex was determined at 2.3 A resolution.

  5. Study demonstrates that GLO1 is a novel metabolic oncogene (show RAB1A Proteins) of the 6p21 amplicon, which promotes tumor growth and aberrant transcriptional signals via regulating cellular metabolic activities for energy production.

  6. the balance between methylglyoxal and age-dependent GLO1 downregulation contributes to delayed wound healing in old mice

  7. The difference in glyoxalase-1 mRNA was observed with Fkbp5 (show FKBP5 Proteins)-/- mice expressing 2-fold more glyoxylase-1 protein.

  8. pharmacological inhibition of GLO1 reduced anxiety, suggesting that GLO1 is a possible target for the treatment of anxiety disorders.

  9. These results suggest that GLO-1 plays a role in high glucose-mediated signaling by reducing mesangial cells accumulation and oxidative stress in diabetes mellitus.

  10. Findings reveal that the abundance of GLO1 varies between different murine strains and within different sensory neuron populations.

Human Glyoxalase I (GLO1) interaction partners

  1. Glo1, together with Glo2 (show HAGH Proteins), represents a novel mechanism in prostate cancer progression driven by a PTEN/PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) signaling pathway.

  2. Gly82Ser and 2184 A/G RAGE (show AGER Proteins) polymorphisms were related to the mortality due to the breast cancer and -419 A/C glyoxalase I polymorphism was related to the overall mortality of the patients suggesting their role not only in the risk of breast cancer but also in the outcome of patients with breast cancer.

  3. Reduction of GLO1 activity in atherosclerotic lesions of nondiabetic patients with increased HbA1c is associated with a functional involvement of this protective enzyme in atherogenesis.

  4. Studies suggest that the enhancement of glyoxalase I (GLO-1) is a promising strategy aimed at halting the vicious cycle between chronic kidney disease and increases in glycative stress.

  5. GLO1 on one hand is crucial to maintaining tumor characteristics of malignant cells, and, on the other hand, supports malignant transformation of cells in a hypoxic environment when overexpressed.

  6. GLO1 SNPs are significantly associated with late-onset and drug-resistant epilepsy.

  7. MS5 (show TNFRSF1A Proteins) induced hydrogen peroxide-mediated c-Jun (show JUN Proteins)-dependent Glo1 up-regulation which resulted in a decrease in the Argpyrimidine-modified Hsp70 (show HSP70 Proteins) protein level which triggered EMT (show ITK Proteins) in a novel mechanism involving miR (show MLXIP Proteins)-21 and SMAD (show SMAD1 Proteins) signalling

  8. MMP-9 (show MMP9 Proteins) and Bcl-2 (show BCL2 Proteins) expression levels were dramatically decreased by addition of methylglyoxal or inhibition of GLOI. These findings may provide a new approach for the treatment of breast cancer.

  9. Data suggest Glo1's effects on anxiety-like behavior are centrally mediated as overexpression of Glo1 in neurons was sufficient to increase anxiety-like behavior

  10. Studies indicate that the most extensively investigated The most extensively investigated glyoxalase enzymes are glyoxalase I and glyoxalase II (show HAGH Proteins) (Glo1 and Glo2 (show HAGH Proteins)).

Glyoxalase I (GLO1) Protein Profile

Protein Summary

The enzyme encoded by this gene is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione. Glyoxalase I is linked to HLA and is localized to 6p21.3-p21.1, between HLA and the centromere.

Gene names and symbols associated with Glyoxalase I Proteins (GLO1)

  • glyoxalase 1 (glo1)
  • glyoxalase I (GLO1)
  • glyoxalase 1 (glo1-b)
  • glyoxalase 1 (glo1-a)
  • lactoylglutathione lyase (glyoxalase I)
  • glyoxalase I homolog (GLX1)
  • glyoxalase I (gloA)
  • glyoxalase I (Bcen_2094)
  • glyoxalase 1 (Glo1)
  • glyoxalase I (Glo1)
  • 0610009E22Rik protein
  • 1110008E19Rik protein
  • 2510049H23Rik protein
  • ATGLX1 protein
  • AW550643 protein
  • cb554 protein
  • F12F1.32 protein
  • F12F1_32 protein
  • Glo-1 protein
  • Glo-1r protein
  • Glo-1s protein
  • GLO1 protein
  • Glo1-r protein
  • Glo1-s protein
  • GLOD1 protein
  • GLY1 protein
  • GLYI protein
  • GLYOXALASE I protein
  • glyoxalase I homolog protein
  • Qglo protein
  • trypanothione-dependent glyoxalase I protein
  • wu:fb82g09 protein
  • zgc:66035 protein

Protein level used designations for Glyoxalase I Proteins (GLO1)

lactoylglutathione lyase , glyoxalase I , hypothetical protein , trypanothione-dependent glyoxalase I , S-D-lactoylglutathione methylglyoxal lyase , aldoketomutase , glx I , glyoxalase 1 complex , glyoxalase 1 regulatory , glyoxalase 1 structural , ketone-aldehyde mutase , methylglyoxalase , glyoxylase 1 , glyoxalase domain containing 1 , lactoyl glutathione lyase

GENE ID SPECIES
368213 Danio rerio
421428 Gallus gallus
446359 Xenopus laevis
447401 Xenopus laevis
547925 Glycine max
594942 Xenopus (Silurana) tropicalis
719518 Macaca mulatta
748215 Pan troglodytes
837731 Arabidopsis thaliana
1248061 Salmonella enterica subsp. enterica serovar Typhi str. CT18
3639312 Candida albicans SC5314
3639398 Candida albicans SC5314
4091104 Burkholderia cenocepacia AU 1054
4850985 Scheffersomyces stipitis CBS 6054
5073200 Leishmania infantum JPCM5
6924240 Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91
6949741 Salmonella enterica subsp. enterica serovar Enteritidis str. P125109
109801 Mus musculus
294320 Rattus norvegicus
2739 Homo sapiens
474894 Canis lupus familiaris
100156085 Sus scrofa
540335 Bos taurus
100726491 Cavia porcellus
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