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The protein encoded by GnRH2 is a preproprotein that is cleaved to form a secreted 10 aa peptide hormone. Additionally we are shipping GnRH2 Proteins (14) and GnRH2 Kits (3) and many more products for this protein.
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Human Polyclonal GnRH2 Primary Antibody for EIA, FACS - ABIN952570
Poon, Hammond, Leung: Epidermal growth factor-induced GnRH-II synthesis contributes to ovarian cancer cell invasion. in Molecular endocrinology (Baltimore, Md.) 2009
Show all 5 references for ABIN952570
cloning of the gene and cDNA encoding cGnRH-II from zebrafish; in situ hybridization analysis of expression in adult zebrafish brains; levels quantified in the pituitary
GnRH loss-of-function affects early brain and eye formation during development.
results suggest GnRH-II-induced laminin receptor precursor expression increases 67-kDa nonintegrin laminin receptor, which appears to interact with laminin in the extracellular matrix to promote MMP-2 (show MMP2 Antibodies) expression and enhance ovarian cancer cell invasion
concluded that GnRHII stimulates PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) pathway, and the phosphorylation of glycogen synthase kinase3beta, thereby enhancing the beta-catenin (show CTNNB1 Antibodies)-dependent up-regulation of MT1-MMP (show MMP14 Antibodies) production which contributes to ovarian cancer metastasis
These preliminary data suggest that local GnRH-II may participate in the regulation of ovarian tumor growth in post-menopausal women.
GnRH-II and GnRH-I (show GNRH1 Antibodies) interact directly with T cells and trigger gene transcription, adhesion, chemotaxis and homing to specific organs, which may be of clinical relevance.
a novel mechanism in stimulating basal human GnRH-II gene transcription mediated by cooperative actions of multiple regulatory elements within the untranslated first exon of the gene.
regulation of GnRH-I (show GNRH1 Antibodies) and GnRH-II gene expression in the ovary
gonadotropin releasing hormone-II is more effective than gonadotropin releasing hormone-I in stimulating leptin (show LEP Antibodies) secretion
GnRH-II has been identified, together with a 'putative' type II GnRH receptor, both in the central nervous system and in peripheral structures, such as tissues of the reproductive tract (both normal and tumoral).
GnRH I (show GNRH1 Antibodies) and GnRH II have both common and discrete cellular distributions in the placenta and decidua and suggest that these two hormones are capable of eliciting their biological actions in an autocrine and/or paracrine manner
Progesterone receptor (show PGR Antibodies) isoform p4 is a potent regulator of GnRHRI at the transcriptional level as well as GnRH I (show GNRH1 Antibodies) mRNA.
The protein encoded by this gene is a preproprotein that is cleaved to form a secreted 10 aa peptide hormone. The secreted decapeptide regulates reproduction in females by stimulating the secretion of both luteinizing- and follicle-stimulating hormones. Three transcript variants that encode unique proproteins but the same peptide hormone have been found for this gene.
cII gonadotropin releasing hormone
, gonadotropin-releasing hormone 2
, GnRHII precursor-like protein
, chicken-II-type gonadotropin-releasing hormone
, progonadoliberin II
, luliberin II
, luteinizing hormone-releasing hormone II
, GnRH-associated peptide II
, chicken luteinizing hormone-releasing hormone II
, gonadoliberin II