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The protein encoded by GRHL2 is a transcription factor that can act as a homodimer or as a heterodimer with either GRHL1 or GRHL3. Additionally we are shipping GRHL2 Antibodies (30) and many more products for this protein.
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Taken together, our results demonstrate a role for miR (show MLXIP Proteins)-217 in the regulation of keratinocyte differentiation, partially through the regulation of GRHL2.
Genetic variations in the EYA4 (show EYA4 Proteins), GRHL2 and DFNA5 (show DFNA5 Proteins) genes and their interactions with occupational noise exposure may play an important role in the incidence of noise-induced hearing loss (NIHL).
GRHL1 (show GRHL1 Proteins), GRHL2, and GRHL3 (show GRHL3 Proteins) have roles in cellular proliferation, differentiation, adhesion, and polarity and may promote cancer or be tumor suppressors [review]
The p63 (show RPE65 Proteins) gene is regulated by GRHL2 through reciprocal feedback and determines the epithelial phenotype in human keratinocytes.
A Grhl2-dependent gene network controls trophoblast branching morphogenesis.
has identified ZEB1 as a target of GRHL2 and suggested a reciprocal GRHL2-ZEB1 repressive relationship, providing a novel mechanism through which proliferation may be modulated in colorectal cancer cells.
Mutations in GRHL2 result in an autosomal-recessive ectodermal Dysplasia syndrome.
Over-expression of Grhl2 decreased c-Myc (show MYC Proteins) and Bcl-2 (show BCL2 Proteins) protein expression level.
These findings indicate that GRHL2 may be a noise-induced hearing loss susceptibility gene and that polymorphisms of GRLH2 may contribute to the etiology of noise-induced hearing loss.
expression of GRHL2 is directly suppressed by the ZEB1, which in turn is a direct target for repression by GRHL2, suggesting that the EMT transcription factors GRHL2 and ZEB1 form a double negative regulatory feedback loop
GRHL2 promotes the epithelial nature of non-neural ectoderm during dynamic events of neural tube formation by both activating key epithelial genes and actively suppressing epithelial-mesenchymal (EMT (show ITK Proteins)) transition through novel downstream EMT (show ITK Proteins) suppressors.
a Grhl2/Ovol2 (show OVOL2 Proteins) network controls Cldn4 (show CLDN4 Proteins) and Rab25 (show RAB25 Proteins) expression that facilitates lumen expansion and barrier formation in subtypes of renal epithelia
Our findings reveal important pathophysiological differences between human pulmonary fibrosis and specific mouse models of fibrosis and support a crucial role of GRHL2 in epithelial activation in lung fibrosis and perhaps also in epithelial plasticity.
Grhl2 plays an essential role in the determination of epithelial phenotype of breast cancers, EMT (show ITK Proteins) and tumor progression
the results indicate that Grhl2 regulates epithelial morphogenesis through transcriptional up-regulation of Cldn3 (show CLDN3 Proteins) and Cldn4 (show CLDN4 Proteins), as well as of Rab25 (show RAB25 Proteins), which increases the Cldn4 (show CLDN4 Proteins) protein and its localization at TJs
Grhl2 and Nkx2-1 (show NKX2-1 Proteins) bind to each other's promoter in vivo, forming a positive feedback regulatory loop.
Over-expression of Grhl2 causes spina bifida in the Axial defects mutant mouse
tissue closure defects in Grhl2 mutants are similar to that of AP-2alpha (show TFAP2A Proteins) null mutants and AP-2alpha (show TFAP2A Proteins) has been shown to bind to the promoter of E-cadherin (show CDH1 Proteins)
Both GRHL2 and GRHL3 (show GRHL3 Proteins) bind to and regulate expression of the wound repair gene Rho GEF (show ARHGEF2 Proteins) 19, but regulation of the barrier forming gene, Transglutaminase 1 (TGase1 (show TGM1 Proteins)), is unique to GRHL3 (show GRHL3 Proteins).
The data showed that midbrain-hindbrain boundary maintenance and morphogenesis are dissociable events regulated by grhl2b through diverse transcriptional targets.
This work reveals an evolutionarily conserved function of Grhl2 in otic development and provides a fish model for further studying mechanisms of Grhl2-related hearing loss.
The protein encoded by this gene is a transcription factor that can act as a homodimer or as a heterodimer with either GRHL1 or GRHL3. Defects in this gene are a cause of non-syndromic sensorineural deafness autosomal dominant type 28 (DFNA28).
grainyhead-like 2 (Drosophila)
, transcription factor CP2-like 3
, brother of mammalian grainyhead
, grainyhead-like protein 2 homolog
, grainyhead like 2
, grainyhead-like 2
, grainyhead-like 2b protein