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Grainyhead-Like 2 (Drosophila) Proteins (GRHL2)

The protein encoded by GRHL2 is a transcription factor that can act as a homodimer or as a heterodimer with either GRHL1 or GRHL3. Additionally we are shipping GRHL2 Antibodies (30) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GRHL2 79977 Q6ISB3
GRHL2 252973 Q8K5C0
Rat GRHL2 GRHL2 299979  
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Top GRHL2 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

GRHL2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Grainyhead-Like 2 (Drosophila) (GRHL2) Interaction Partners

Human Grainyhead-Like 2 (Drosophila) (GRHL2) interaction partners

  1. Taken together, our results demonstrate a role for miR (show MLXIP Proteins)-217 in the regulation of keratinocyte differentiation, partially through the regulation of GRHL2.

  2. Genetic variations in the EYA4 (show EYA4 Proteins), GRHL2 and DFNA5 (show DFNA5 Proteins) genes and their interactions with occupational noise exposure may play an important role in the incidence of noise-induced hearing loss (NIHL).

  3. GRHL1 (show GRHL1 Proteins), GRHL2, and GRHL3 (show GRHL3 Proteins) have roles in cellular proliferation, differentiation, adhesion, and polarity and may promote cancer or be tumor suppressors [review]

  4. The p63 (show RPE65 Proteins) gene is regulated by GRHL2 through reciprocal feedback and determines the epithelial phenotype in human keratinocytes.

  5. A Grhl2-dependent gene network controls trophoblast branching morphogenesis.

  6. has identified ZEB1 as a target of GRHL2 and suggested a reciprocal GRHL2-ZEB1 repressive relationship, providing a novel mechanism through which proliferation may be modulated in colorectal cancer cells.

  7. Mutations in GRHL2 result in an autosomal-recessive ectodermal Dysplasia syndrome.

  8. Over-expression of Grhl2 decreased c-Myc (show MYC Proteins) and Bcl-2 (show BCL2 Proteins) protein expression level.

  9. These findings indicate that GRHL2 may be a noise-induced hearing loss susceptibility gene and that polymorphisms of GRLH2 may contribute to the etiology of noise-induced hearing loss.

  10. expression of GRHL2 is directly suppressed by the ZEB1, which in turn is a direct target for repression by GRHL2, suggesting that the EMT transcription factors GRHL2 and ZEB1 form a double negative regulatory feedback loop

Mouse (Murine) Grainyhead-Like 2 (Drosophila) (GRHL2) interaction partners

  1. GRHL2 promotes the epithelial nature of non-neural ectoderm during dynamic events of neural tube formation by both activating key epithelial genes and actively suppressing epithelial-mesenchymal (EMT (show ITK Proteins)) transition through novel downstream EMT (show ITK Proteins) suppressors.

  2. a Grhl2/Ovol2 (show OVOL2 Proteins) network controls Cldn4 (show CLDN4 Proteins) and Rab25 (show RAB25 Proteins) expression that facilitates lumen expansion and barrier formation in subtypes of renal epithelia

  3. Our findings reveal important pathophysiological differences between human pulmonary fibrosis and specific mouse models of fibrosis and support a crucial role of GRHL2 in epithelial activation in lung fibrosis and perhaps also in epithelial plasticity.

  4. expression of GRHL2 is directly suppressed by the ZEB1, which in turn is a direct target for repression by GRHL2, suggesting that the EMT transcription factors GRHL2 and ZEB1 form a double negative regulatory feedback loop

  5. Grhl2 plays an essential role in the determination of epithelial phenotype of breast cancers, EMT (show ITK Proteins) and tumor progression

  6. the results indicate that Grhl2 regulates epithelial morphogenesis through transcriptional up-regulation of Cldn3 (show CLDN3 Proteins) and Cldn4 (show CLDN4 Proteins), as well as of Rab25 (show RAB25 Proteins), which increases the Cldn4 (show CLDN4 Proteins) protein and its localization at TJs

  7. Grhl2 and Nkx2-1 (show NKX2-1 Proteins) bind to each other's promoter in vivo, forming a positive feedback regulatory loop.

  8. Over-expression of Grhl2 causes spina bifida in the Axial defects mutant mouse

  9. tissue closure defects in Grhl2 mutants are similar to that of AP-2alpha (show TFAP2A Proteins) null mutants and AP-2alpha (show TFAP2A Proteins) has been shown to bind to the promoter of E-cadherin (show CDH1 Proteins)

  10. Both GRHL2 and GRHL3 (show GRHL3 Proteins) bind to and regulate expression of the wound repair gene Rho GEF (show ARHGEF2 Proteins) 19, but regulation of the barrier forming gene, Transglutaminase 1 (TGase1 (show TGM1 Proteins)), is unique to GRHL3 (show GRHL3 Proteins).

Zebrafish Grainyhead-Like 2 (Drosophila) (GRHL2) interaction partners

  1. The data showed that midbrain-hindbrain boundary maintenance and morphogenesis are dissociable events regulated by grhl2b through diverse transcriptional targets.

  2. This work reveals an evolutionarily conserved function of Grhl2 in otic development and provides a fish model for further studying mechanisms of Grhl2-related hearing loss.

GRHL2 Protein Profile

Protein Summary

The protein encoded by this gene is a transcription factor that can act as a homodimer or as a heterodimer with either GRHL1 or GRHL3. Defects in this gene are a cause of non-syndromic sensorineural deafness autosomal dominant type 28 (DFNA28).

Gene names and symbols associated with GRHL2

  • grainyhead-like 2 (Drosophila) (GRHL2)
  • grainyhead-like 2 (Drosophila) (Grhl2)
  • grainyhead-like 2b (Drosophila) (grhl2b)
  • 0610015A08Rik protein
  • BOM protein
  • DFNA28 protein
  • grhl2 protein
  • RGD1561191 protein
  • si:dkey-21k18.2 protein
  • Tcfcp2l3 protein
  • TFCP2L3 protein

Protein level used designations for GRHL2

grainyhead-like 2 (Drosophila) , transcription factor CP2-like 3 , brother of mammalian grainyhead , grainyhead-like protein 2 homolog , grainyhead like 2 , grainyhead-like 2 , grainyhead-like 2b protein

GENE ID SPECIES
464320 Pan troglodytes
706549 Macaca mulatta
100056140 Equus caballus
429506 Gallus gallus
79977 Homo sapiens
481985 Canis lupus familiaris
519918 Bos taurus
252973 Mus musculus
299979 Rattus norvegicus
100034503 Danio rerio
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