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The product of GNLY is a member of the saposin-like protein (SAPLIP) family and is located in the cytotoxic granules of T cells, which are released upon antigen stimulation. Additionally we are shipping Granulysin Antibodies (77) and Granulysin Kits (13) and many more products for this protein.
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Human GNLY Protein expressed in NSO cells - ABIN2666969
Kalb, Glaser, Stary, Koszik, Stingl: TRAIL(+) human plasmacytoid dendritic cells kill tumor cells in vitro: mechanisms of imiquimod- and IFN-?-mediated antitumor reactivity. in Journal of immunology (Baltimore, Md. : 1950) 2012
Show all 3 references for ABIN2666969
Human GNLY Protein expressed in Wheat germ - ABIN1355419
Chung, Hung, Yang, Su, Huang, Wei, Chin, Chiou, Chu, Ho, Yang, Lu, Wu, Liao, Chen: Granulysin is a key mediator for disseminated keratinocyte death in Stevens-Johnson syndrome and toxic epidermal necrolysis. in Nature medicine 2008
serum GNLY is closely associated with the clinical characteristics of nasopharyngeal carcinoma and may be a potential biomarker for nasopharyngeal carcinoma
GNLY delivers Gzms into three protozoan parasites (Trypanosoma cruzi, Toxoplasma gondii and Leishmania major), in which the Gzms generate superoxide and inactivate oxidative defense enzymes to kill the parasite.
Studies indicate that cytotoxic mechanisms mediated by granulysin and TRAIL (TNF-related apoptosis inducing ligand (show TNFSF10 Proteins)) seem to be less secondary effects on normal tissues.
High Granulysin expression is associated with Cutaneous T Cell Lymphoma and Sezary Syndrome.
A three-way interaction between SNPs in HLA-DQ and GNLY was identified in terms of HBV clearance.
GNLY-expressing lymphocytes, probably attracted by IL-15 (show IL15 Proteins), not only participate partially in myocardial cell apoptosis, but also hasten resolution of cardiac leukocyte infiltration in patients with myocardial infarction.
Serum granulysin levels were significantly elevated in both acute and chronic alopecia areata patients.
Human, but not rodent, cytotoxic granules also contain granulysin, an antimicrobial peptide (show cAMP Proteins) in addition to granzymes; study shows that granulysin delivers granzymes into bacteria to kill diverse bacterial strains.
It was concluded taht granulysin induces apoptosis on hematological tumor cells and on cells from B-cell lymphocytic leukemia patients, opening the door to research on its use as a new anti-tumoral treatment.
suggested that the alteration of circulating granulysin has potential function in host immune response against TB and HIV/TB coinfection
Intercaruncular epithelium granulysin may play important roles in the establishment and maintenance of gestation during normal pregnancy.
The product of this gene is a member of the saposin-like protein (SAPLIP) family and is located in the cytotoxic granules of T cells, which are released upon antigen stimulation. This protein is present in cytotoxic granules of cytotoxic T lymphocytes and natural killer cells, and it has antimicrobial activity against M. tuberculosis and other organisms. Alternatively spliced transcript variants encoding different isoforms have been identified.
, T-cell activation protein 519
, T-lymphocyte activation gene 519
, lymphocyte-activation gene 2
, lymphokine LAG-2