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GREM1 encodes a member of the BMP (bone morphogenic protein) antagonist family. Additionally we are shipping Gremlin 1 Kits (37) and Gremlin 1 Proteins (34) and many more products for this protein.
Showing 10 out of 129 products:
Human Polyclonal GREM1 Primary Antibody for IHC (p), WB - ABIN390078
Jara, Chacón, Burgos, Droguett, Valdivieso, Ortiz, Troncoso, Mezzano: Expression of gremlin, a bone morphogenetic protein antagonist,is associated with vascular calcification in uraemia. in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2009
Show all 10 references for ABIN390078
Human Polyclonal GREM1 Primary Antibody for IHC (p), IHC - ABIN252810
Okamoto, Lezhava, Hosaka, Okamoto-Hosoya, Ochi: Enhanced expression of S-adenosylmethionine synthetase causes overproduction of actinorhodin in Streptomyces coelicolor A3(2). in Journal of bacteriology 2003
Show all 5 references for ABIN252810
Human Polyclonal GREM1 Primary Antibody for EIA, WB - ABIN952628
Dimitrov, Voet, De Smet, Vermeesch, Devriendt, Fryns, Debeer: Genomic rearrangements of the GREM1-FMN1 locus cause oligosyndactyly, radio-ulnar synostosis, hearing loss, renal defects syndrome and Cenani--Lenz-like non-syndromic oligosyndactyly. in Journal of medical genetics 2010
Show all 5 references for ABIN952628
Human Monoclonal GREM1 Primary Antibody for ELISA, WB - ABIN565294
Sha, Zhang, Zhang, Wan, Zhao, Li, Lang: Elevated levels of gremlin-1 in eutopic endometrium and peripheral serum in patients with endometriosis. in Fertility and sterility 2009
Human Polyclonal GREM1 Primary Antibody for IF (p), IHC (p) - ABIN687082
Wellbrock, Sheikhzadeh, Oliveira-Ferrer, Stamm, Hillebrand, Keyser, Klokow, Vohwinkel, Bonk, Otto, Streichert, Balabanov, Hagel, Rybczynski, Bentzien, Bokemeyer, von Kodolitsch, Fiedler: Overexpression of Gremlin-1 in patients with Loeys-Dietz syndrome: implications on pathophysiology and early disease detection. in PLoS ONE 2014
FGF signaling in establishment of the developmental hematopoietic stem cell niche occurs via inhibition of bmp4 (show BMP4 Antibodies) transcription, and activation of bmp antagonists, nog2 and grem1a.
Results suggest that the negative regulatory loops between BMP/Tbx2 (show TBX2 Antibodies) and Gremlin or Hey1 (show HEY1 Antibodies) are responsible for defining the territory of the pronephric nephron.
Gremlin encodes a maternal transcript, and the zygotic transcription is turned on at the mid-blastula transition.
Data show that parathyroid hormone-related protein (PTHrP (show PTHLH Antibodies)) regulates gremlin levels in pancreatic acinar and stellate cells.
Gremlin is a key pro-fibrogenic factor in chronic pancreatitis
Gremlin/VEGFR2 (show KDR Antibodies) axis participates in renal inflammation and could be a novel target for kidney disease.
GREM1 induces fibrosis and angiogenesis in mouse peritoneum and is associated with increased solute transport in peritoneal dialysis patients.
Grem1 expression identifies distinct connective tissue stem cells in both the bone (osteochondroreticular stem cells) and the intestine (reticular stem cells).
A Gli (show GLI1 Antibodies)-dependent cis (show CISH Antibodies)-regulatory module (CRM), regulation of Grem1 in the mouse limb bud, is reported.
Suggest cross-talk between angiogenesis and inflammation and demonstrate a crucial role of CREB (show CREB1 Antibodies) activation in the modulation of the VEGFR2 (show KDR Antibodies)-mediated proinflammatory/proangiogenic response of endothelial cells to gremlin.
The present data disclose that Gremlin-1 is an endogenous antagonist of MIF (show MIF Antibodies) and define a role for Gremlin-1/MIF (show MIF Antibodies) interaction in atherosclerosis.
endogenous Gremlin blockade inhibited TGF-beta (show TGFB1 Antibodies)-mediated matrix production and epithelial mesenchymal transition in kidney fibroblasts
gremlin was clearly elevated in high glucose cultured mouse podocytes, and likely employed endogenous canonical TGFbeta1 (show TGFB1 Antibodies)/Smad (show SMAD1 Antibodies) signaling to induce podocyte injury. Knockdown gremlin1 by siRNA may be clinically useful in the attenuation of podocyte injury.
Wattles in goats are associated with the FMN1 (show FMN1 Antibodies)/GREM1 region on chromosome 10
Diabetic patients with acute coronary syndrome show increased levels of Gremlin-1 and MIF (show AMH Antibodies), leading to unfavorable Gremlin-1/MIF (show AMH Antibodies) ratios. However, DM2 (show CNBP Antibodies) alone is not associated with low Gremlin-1/MIF (show AMH Antibodies) ratios.
The critical element of the Gremlin-1 molecule for regulating MIF (show AMH Antibodies)-induced chemotactic activity lies at the C-terminal region. A single amino acid exchange of an arginine to an alanine residue is sufficient to abolish the antagonistic effect of Gremlin-1 on MIF (show AMH Antibodies). The Gremlin-1 mutant R172A failed to reduce MIF (show AMH Antibodies)-induced monocyte differentiation into macrophages.
Study identified a high penetrant duplication in the regulatory region of GREM1, predisposing to colorectal cancer (CRC (show CALR Antibodies)) in a family with attenuated/ atypical polyposis. A POLE variant was also identified in a patient with early onset CRC (show CALR Antibodies).
Results found that high mRNA expression level of Gremlin 1 was an independent poor prognostic factor for cervical neoplasm. it is suggested that Gremlin 1 may have a role in clinical recurrence and maintaining cancer stem cell-like properties.
our data suggest that the closely located GREM1 gene contributes to a rare clinical Nonsyndromic orofacial clefts entity
results might suggest that variants influencing GREM1 expression levels, rather than variants affecting the function of the encoded protein, are significant factors in NSCL (show NHLH1 Antibodies)/P etiology.
Data suggest that the hereditary mixed polyposis syndrome (HMPS) 40 kb duplication upstream of the gremlin 1 protein (GREM1) gene is present at low rates in Jewish Ashkenazi individuals of a familial predisposition to colorectal cancer (CRC (show CALR Antibodies)).
Gremlin-1 plasma levels of Loeys-Dietz syndrome patients were significantly elevated compared to healthy control subjects.
transgenic mice overexpressing Gremlin in renal tubules develop greater glomerular and tubulointerstitial injury in response to diabetic-mediated damage
both the regenerating and contralateral, developing limb of grem1 transgenics developed skeletal defects, suggesting that overexpressing grem1 negatively affects limb patterning
This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
gremlin 1 homolog a, cysteine knot superfamily
, gremlin 1 homolog, cysteine knot superfamily
, gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis)
, gremlin 1
, cysteine knot superfamily 1
, cysteine knot superfamily 1, BMP antagonist 1
, down-regulated in Mos-transformed cells protein
, down-regulated in v-mos-transformed cells
, gremlin 1, cysteine knot superfamily, homolog
, Cysteine knot superfamily 1, BMP antagonist 1
, DAN domain family member 2
, cell proliferation-inducing gene 2 protein
, gremlin 1-like protein
, increased in high glucose-2