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anti-Gremlin 1 (GREM1) Antibodies

GREM1 encodes a member of the BMP (bone morphogenic protein) antagonist family. Additionally we are shipping Gremlin 1 Kits (38) and Gremlin 1 Proteins (31) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GREM1 23892 O70326
GREM1 50566 O35793
GREM1 26585 O60565
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Top anti-Gremlin 1 Antibodies at antibodies-online.com

Showing 10 out of 125 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of anti-Gremlin Pab (ABIN390078) in CEM cell line lysates (35 µg/lane). Gremlin (arrow) was detected using the purified polyclonal antibody. Western blot analysis of anti-Gremlin Pab (ABIN390078) in mouse liver cell lysate. Gremlin (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of GREM1 (arrow) using Gremlin-1 / GREM1 Antibody (C-term) Cat.-No AP51947PU-N. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the GREM1 gene. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human colon carcinoma labeled with Rabbit Anti-gremlin Polyclonal Antibody (ABIN687082) at 1:200 followed by conjugation to the secondary antibody and DAB staining. Formalin-fixed and paraffin embedded rat brain tissue labeled with Rabbit Anti-gremlin Polyclonal Antibody (ABIN687082) at 1:200 followed by conjugation to the secondary antibody and DAB staining. 100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB Host: Rabbit  Target Name: Grem1  Sample Tissue: Rat Testis lysates  Antibody Dilution: 1.0 µg/mL 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB Host: Rabbit  Target Name: Grem1  Sample Tissue: Mouse Testis lysates  Antibody Dilution: 1.0 µg/mL 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of GREM1 (arrow) using rabbit polyclonal GREM1 Antibody (C-term) (ABIN656181). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the GREM1 gene. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Rat Rabbit Un-conjugated WB Observed bind size: 23KD 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated WB Immunohistochemistry with Gremlin 1 Polyclonal Antibody Western blot with Gremlin 1 Polyclonal Antibody 0.1 mg Log in to see 6 to 8 Days
$313.50
Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged GREM1 is approximately 1ng/ml as a capture antibody. Western Blot detection against Immunogen (37.84 KDa) . 100 μg Log in to see 9 Days
$430.00
Details

GREM1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Gremlin 1 Antibodies

  1. Human Polyclonal GREM1 Primary Antibody for IHC (p), WB - ABIN390078 : Jara, Chacón, Burgos, Droguett, Valdivieso, Ortiz, Troncoso, Mezzano: Expression of gremlin, a bone morphogenetic protein antagonist,is associated with vascular calcification in uraemia. in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2009 (PubMed)
    Show all 10 references for ABIN390078

  2. Human Polyclonal GREM1 Primary Antibody for EIA, WB - ABIN952628 : Dimitrov, Voet, De Smet, Vermeesch, Devriendt, Fryns, Debeer: Genomic rearrangements of the GREM1-FMN1 locus cause oligosyndactyly, radio-ulnar synostosis, hearing loss, renal defects syndrome and Cenani--Lenz-like non-syndromic oligosyndactyly. in Journal of medical genetics 2010 (PubMed)
    Show all 5 references for ABIN952628

  3. Human Monoclonal GREM1 Primary Antibody for ELISA, WB - ABIN565294 : Sha, Zhang, Zhang, Wan, Zhao, Li, Lang: Elevated levels of gremlin-1 in eutopic endometrium and peripheral serum in patients with endometriosis. in Fertility and sterility 2009 (PubMed)

  4. Human Polyclonal GREM1 Primary Antibody for IF (p), IHC (p) - ABIN687082 : Wellbrock, Sheikhzadeh, Oliveira-Ferrer, Stamm, Hillebrand, Keyser, Klokow, Vohwinkel, Bonk, Otto, Streichert, Balabanov, Hagel, Rybczynski, Bentzien, Bokemeyer, von Kodolitsch, Fiedler: Overexpression of Gremlin-1 in patients with Loeys-Dietz syndrome: implications on pathophysiology and early disease detection. in PLoS ONE 2014 (PubMed)

More Antibodies against Gremlin 1 Interaction Partners

Zebrafish Gremlin 1 (GREM1) interaction partners

  1. FGF signaling in establishment of the developmental hematopoietic stem cell niche occurs via inhibition of bmp4 (show BMP4 Antibodies) transcription, and activation of bmp antagonists, nog2 and grem1a.

  2. Results suggest that the negative regulatory loops between BMP/Tbx2 (show TBX2 Antibodies) and Gremlin or Hey1 (show HEY1 Antibodies) are responsible for defining the territory of the pronephric nephron.

  3. Gremlin encodes a maternal transcript, and the zygotic transcription is turned on at the mid-blastula transition.

Mouse (Murine) Gremlin 1 (GREM1) interaction partners

  1. Gremlin is a key pro-fibrogenic factor in chronic pancreatitis

  2. Gremlin/VEGFR2 (show KDR Antibodies) axis participates in renal inflammation and could be a novel target for kidney disease.

  3. GREM1 induces fibrosis and angiogenesis in mouse peritoneum and is associated with increased solute transport in peritoneal dialysis patients.

  4. Grem1 expression identifies distinct connective tissue stem cells in both the bone (osteochondroreticular stem cells) and the intestine (reticular stem cells).

  5. A Gli (show GLI1 Antibodies)-dependent cis (show CISH Antibodies)-regulatory module (CRM), regulation of Grem1 in the mouse limb bud, is reported.

  6. Suggest cross-talk between angiogenesis and inflammation and demonstrate a crucial role of CREB (show CREB1 Antibodies) activation in the modulation of the VEGFR2 (show KDR Antibodies)-mediated proinflammatory/proangiogenic response of endothelial cells to gremlin.

  7. The present data disclose that Gremlin-1 is an endogenous antagonist of MIF (show MIF Antibodies) and define a role for Gremlin-1/MIF (show MIF Antibodies) interaction in atherosclerosis.

  8. endogenous Gremlin blockade inhibited TGF-beta (show TGFB1 Antibodies)-mediated matrix production and epithelial mesenchymal transition in kidney fibroblasts

  9. gremlin was clearly elevated in high glucose cultured mouse podocytes, and likely employed endogenous canonical TGFbeta1 (show TGFB1 Antibodies)/Smad (show SMAD1 Antibodies) signaling to induce podocyte injury. Knockdown gremlin1 by siRNA may be clinically useful in the attenuation of podocyte injury.

  10. This study establishes that distant cis (show CISH Antibodies)-regulatory regions scattered through a larger genomic landscape control the highly dynamic expression of Grem1, which is key to normal progression of mouse limb bud development.

Goat Gremlin 1 (GREM1) interaction partners

  1. Wattles in goats are associated with the FMN1 (show FMN1 Antibodies)/GREM1 region on chromosome 10

Human Gremlin 1 (GREM1) interaction partners

  1. Study identified a high penetrant duplication in the regulatory region of GREM1, predisposing to colorectal cancer (CRC (show CALR Antibodies)) in a family with attenuated/ atypical polyposis. A POLE variant was also identified in a patient with early onset CRC (show CALR Antibodies).

  2. Results found that high mRNA expression level of Gremlin 1 was an independent poor prognostic factor for cervical neoplasm. it is suggested that Gremlin 1 may have a role in clinical recurrence and maintaining cancer stem cell-like properties.

  3. our data suggest that the closely located GREM1 gene contributes to a rare clinical Nonsyndromic orofacial clefts entity

  4. results might suggest that variants influencing GREM1 expression levels, rather than variants affecting the function of the encoded protein, are significant factors in NSCL (show NHLH1 Antibodies)/P etiology.

  5. Gremlin is a key pro-fibrogenic factor in chronic pancreatitis

  6. Data suggest that the hereditary mixed polyposis syndrome (HMPS) 40 kb duplication upstream of the gremlin 1 protein (GREM1) gene is present at low rates in Jewish Ashkenazi individuals of a familial predisposition to colorectal cancer (CRC (show CALR Antibodies)).

  7. Gremlin-1 plasma levels of Loeys-Dietz syndrome patients were significantly elevated compared to healthy control subjects.

  8. transgenic mice overexpressing Gremlin in renal tubules develop greater glomerular and tubulointerstitial injury in response to diabetic-mediated damage

  9. Results demonstrated that miR (show MLXIP Antibodies)-27b targets Gremlin 1, and that this regulation likely represents an important control point in fi brotic pathways.

  10. Gremlin/VEGFR2 (show KDR Antibodies) axis participates in renal inflammation and could be a novel target for kidney disease.

Xenopus laevis Gremlin 1 (GREM1) interaction partners

  1. both the regenerating and contralateral, developing limb of grem1 transgenics developed skeletal defects, suggesting that overexpressing grem1 negatively affects limb patterning

Gremlin 1 (GREM1) Antigen Profile

Protein Summary

This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with anti-Gremlin 1 (GREM1) Antibodies

  • gremlin 1 homolog a, cysteine knot superfamily (Xenopus laevis) (grem1a) antibody
  • gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis) (GREM1) antibody
  • gremlin 1 (Grem1) antibody
  • gremlin 1 (grem1) antibody
  • gremlin 1 (GREM1) antibody
  • gremlin 1, DAN family BMP antagonist (GREM1) antibody
  • gremlin 1, DAN family BMP antagonist (Grem1) antibody
  • gremlin 1, DAN family BMP antagonist (grem1) antibody
  • gremlin-1 (LOC100342066) antibody
  • gremlin-1-like (LOC100156280) antibody
  • cktsf1b1 antibody
  • DAND2 antibody
  • DRM antibody
  • Grem antibody
  • GREM1 antibody
  • GREMLIN antibody
  • gremlin-1 antibody
  • IHG-2 antibody
  • ld antibody
  • MGC136702 antibody
  • pig2 antibody
  • zgc:136702 antibody

Protein level used designations for anti-Gremlin 1 (GREM1) Antibodies

gremlin 1 homolog a, cysteine knot superfamily , gremlin 1 homolog, cysteine knot superfamily , gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis) , gremlin 1 , GLEAN_07044 , cysteine knot superfamily 1 , cysteine knot superfamily 1, BMP antagonist 1 , down-regulated in Mos-transformed cells protein , down-regulated in v-mos-transformed cells , gremlin-1 , gremlin 1, cysteine knot superfamily, homolog , Cysteine knot superfamily 1, BMP antagonist 1 , DAN domain family member 2 , cell proliferation-inducing gene 2 protein , gremlin 1-like protein , increased in high glucose-2

GENE ID SPECIES
405778 Danio rerio
467642 Pan troglodytes
662541 Tribolium castaneum
100101711 Xenopus (Silurana) tropicalis
23892 Mus musculus
50566 Rattus norvegicus
100860969 Capra hircus
487475 Canis lupus familiaris
539079 Bos taurus
395826 Gallus gallus
101102396 Ovis aries
574176 Macaca mulatta
26585 Homo sapiens
100730568 Cavia porcellus
399094 Xenopus laevis
100342066 Oryctolagus cuniculus
100156280 Sus scrofa
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