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The protein encoded by GAP43 has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. Additionally we are shipping GAP43 Kits (51) and GAP43 Proteins (20) and many more products for this protein.
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Chicken Polyclonal GAP43 Primary Antibody for ICC, IHC (fro) - ABIN152489
Ferguson, Muir: MMP-2 and MMP-9 increase the neurite-promoting potential of schwann cell basal laminae and are upregulated in degenerated nerve. in Molecular and cellular neurosciences 2000
Show all 39 references for ABIN152489
Human Monoclonal GAP43 Primary Antibody for WB - ABIN393319
Rose, Behm, Drgon, Johnson, Uhl: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. in Molecular medicine (Cambridge, Mass.) 2010
Show all 5 references for ABIN393319
Human Monoclonal GAP43 Primary Antibody for IF, WB - ABIN968792
Chapman, Estep, Storm: Palmitylation of neuromodulin (GAP-43) is not required for phosphorylation by protein kinase C. in The Journal of biological chemistry 1993
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Cow (Bovine) Polyclonal GAP43 Primary Antibody for IHC (fro), WB - ABIN372649
He, Dent, Meiri: Modulation of actin filament behavior by GAP-43 (neuromodulin) is dependent on the phosphorylation status of serine 41, the protein kinase C site. in The Journal of neuroscience : the official journal of the Society for Neuroscience 1997
Show all 4 references for ABIN372649
Human Polyclonal GAP43 Primary Antibody for IF - ABIN401572
Neve, Coopersmith, McPhie, Santeufemio, Pratt, Murphy, Lynn: The neuronal growth-associated protein GAP-43 interacts with rabaptin-5 and participates in endocytosis. in The Journal of neuroscience : the official journal of the Society for Neuroscience 1998
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Human Polyclonal GAP43 Primary Antibody for IF, IHC (p) - ABIN197546
Shen, Mani, Donovan, Schwob, Meiri: Growth-associated protein-43 is required for commissural axon guidance in the developing vertebrate nervous system. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2001
Show all 3 references for ABIN197546
Chicken Monoclonal GAP43 Primary Antibody for IHC (fro), IF - ABIN1107311
Kosik, Orecchio, Bruns, Benowitz, MacDonald, Cox, Neve: Human GAP-43: its deduced amino acid sequence and chromosomal localization in mouse and human. in Neuron 1990
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Rat (Rattus) Monoclonal GAP43 Primary Antibody for ICC, IF - ABIN1580421
Skene, Willard: Changes in axonally transported proteins during axon regeneration in toad retinal ganglion cells. in The Journal of cell biology 1981
The peripheral neuropathies lead to an initial increase in GAP-43 gene expression as a potential mechanism of regeneration, which is not sustained in neuropathies of long duration.
Results show that PKC (show PRRT2 Antibodies)-dependent phosphorylation of GAP43 plays a critical role in regulating postsynaptic gephyrin (show GPHN Antibodies) aggregation in developing GABAergic synapses.
increased expression of TH and GAP43 might be a molecular mechanism for left atrial myoelectricity remodeling of aging atrial fibrillation patients, which might be potential therapeutic targets of atrial fibrillation.
GAP43 is seemingly a highly sensitive marker for peripheral nerve sheath tumors
The results showed that the decreased GAP-43 levels induced by glutamate (show GRIN1 Antibodies) could be partially reversed by the presence of NRG-1beta
Dynamic palmitoylation links cytosol-membrane shuttling of acyl-protein thioesterase-1 (show LYPLA1 Antibodies) and acyl-protein thioesterase-2 (show LYPLA2 Antibodies) with that of proto-oncogene (show RAB1A Antibodies) H-ras (show HRAS Antibodies) product and growth-associated protein-43
immunostaning for GAP-43 was relatively similar in ganglionic versus aganglionic colon.
Impaired regeneration of intra-epidermal C fibers in the early stages of type 2 diabetes mellitus, as indicated by GAP-43 expression, might be a marker of incipient diabetic neuropathy.
The results of this study supported to the hypothesis of multiple rare mutations in schizophrenia, and it provides genetic clues that indicate the involvement of GAP-43 in this disorder.
Through MEK (show MAP2K1 Antibodies)/ERK (show EPHB2 Antibodies) pathway, S1P (show MBTPS1 Antibodies) stimulates GAP43 transcription with increased binding of C/EBPbeta (show CEBPB Antibodies) to the 5'-promoter
hnRNP (show HNRNPH2 Antibodies)-Q1-mediated repression of Gap-43 mRNA translation provides an additional mechanism for regulating GAP-43 expression and function and may be critical for neuronal development.
The GASP (show GPRASP1 Antibodies)-43 is involves in the orientation of cell division by interacting with Galphai.
Trimethyltin decreased synaptophysin (show SYP Antibodies) but not GAP-43 expression in the mouse hippocampus.
Antiretroviral drugs may recruit the HuD (show ELAVL4 Antibodies)-GAP43 pathway, potentially contributing to a response to the antiretroviral neuronal toxicity.
KSRP (show KHSRP Antibodies) modulation of GAP-43 mRNA stability restricts axonal outgrowth in embryonic hippocampal neurons.
these findings suggest that GAP-43 is dynamically involved in early postnatal and adult hippocampal neurogenesis and synaptic connectivity, possibly contributing to the GAP-43+/- behavioral phenotype.
In this review, GAP-43 in vivo knockdown in olivary neurons leads to the atrophy of their climbing fibers and a reduction in the ability to sprout toward surrounding denervated Purkinje cells.
GAP-43 is required to sustain synaptic stability and promote the initiation of axonal regrowth
In vitro results indicated that GAP43 is indeed expressed in both myoblasts and differentiating myotubes, and its cellular localization changes dramatically during maturation.
Initial emergence of hollows in the somatosensory cortex is no different between GAP43 heterozygous mice and nonheterozygous littermate controls; however, the emergence of sides and septa (show SEPT2 Antibodies) is delayed by 2 days.
these results and GAP43 structural features, support an involvement of the protein in the dynamic intracellular Ca2 (show CA2 Antibodies)+ homeostasis, a common conserved role among the different species.
The results implicate the GAP43 pathway as part of an F-actin based mechanism that both stabilizes new synapses and initiates new branches near effective synapses.
The present data strongly suggest that phospho-GAP43 plays an active role in both the early and late stages of optic nerve regeneration in fish.
Both the synthetic N-terminal peptide GAP-43(1-40) and the brain-derived fragment GAP-43-3 preserved the ability to oligomerize under the action of acidic phospholipids and SDS (show SDS Antibodies).
These results indicated the interaction of GAP-43 and Galpha(o (show GNAO1 Antibodies)) could accelerate conversion of depalmitoylated Galpha(o (show GNAO1 Antibodies)) but not palmitoylated Galpha(o (show GNAO1 Antibodies)) from oligomers to monomers, so as to increase the GTPgammaS binding activity of Galpha(o (show GNAO1 Antibodies)).
The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
growth associated protein 43
, axonal membrane protein GAP-43
, brain abundant, membrane attached signal protein 2
, growth accentuating protein 43
, growth-associated protein 43
, protein F1
, calmodulin-binding protein P-57
, nerve growth-related peptide GAP43
, neural phosphoprotein B-50
, neuron growth-associated protein 43
, growth associated protein 43 a
, growth associated protein 43 b