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Guanine Nucleotide Binding Protein-Like 3 (Nucleolar)-Like Proteins (GNL3L)

The protein encoded by GNL3L appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Additionally we are shipping GNL3L Antibodies (50) and GNL3L Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GNL3L 54552 Q9NVN8
GNL3L 237107 Q6PGG6
Rat GNL3L GNL3L 100034253  
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Top GNL3L Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

GNL3L Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
, ,
Mouse (Murine)

More Proteins for Guanine Nucleotide Binding Protein-Like 3 (Nucleolar)-Like (GNL3L) Interaction Partners

Human Guanine Nucleotide Binding Protein-Like 3 (Nucleolar)-Like (GNL3L) interaction partners

  1. the present study provides evidence that GNL3L is exported from the nucleus in CRM1 dependent manner and the nuclear localization of GNL3L is important to promote 'S' phase progression during cell proliferation.

  2. GNL3L depletion impairs ribosome production without inducing appreciable DNA damage. During evolution, GNL3L retained the role of the ancestral gene in ribosome biosynthesis, whereas the paralogous nucleostemin (show E2IG3 Proteins) acquired a novel genome-protective function.

  3. differences in the relative nucleostemin (show E2IG3 Proteins) protein and mRNA levels may reflect the degree of proliferation of mesnchymal stem cells and can be used to characterize in vitro expansion capabilities

  4. GNL3L bound MDM2 (show MDM2 Proteins) in vivo, stabilizing MDM2 (show MDM2 Proteins) and preventing its ubiquitylation. GNL3L depletion upregulated specific p53 (show TP53 Proteins) targets (Bax (show BAX Proteins), 14-3-3sigma and p21 (show CDKN1A Proteins)).

  5. analysis uncovers an important role for Grn1p/GNL3L within this unique group of nucleolar GTPases

  6. GNL3L is composed of distinct modules, each of which plays a specific role in molecular interactions for its nucleolar retention and subsequent function(s) within the nucleolus

Mouse (Murine) Guanine Nucleotide Binding Protein-Like 3 (Nucleolar)-Like (GNL3L) interaction partners

  1. work reveals a novel mechanism that negatively regulates the transcriptional function of ERRgamma (estrogen-related receptor (show ESRRG Proteins))by GNL3L through coactivator competition.

  2. GNL3L mediates the mitotic increase of TRF1 (show TERF1 Proteins) protein and promotes the metaphase-to-anaphase transition.

GNL3L Protein Profile

Protein Summary

The protein encoded by this gene appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Two transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with GNL3L

  • guanine nucleotide binding protein-like 3 (nucleolar)-like (gnl3l)
  • guanine nucleotide binding protein-like 3 (nucleolar)-like (GNL3L)
  • guanine nucleotide binding protein-like 3 (nucleolar)-like (Gnl3l)
  • BC020354 protein
  • flj10613 protein
  • flj10613l protein
  • si:dkey-13a21.8 protein
  • SI:zK13A21.8 protein
  • zgc:110536 protein

Protein level used designations for GNL3L

guanine nucleotide-binding protein-like 3-like protein , guanine nucleotide binding protein-like 3 (nucleolar)-like , guanine nucleotide-binding protein-like 3-like protein-like , novel GTPase

GENE ID SPECIES
442932 Danio rerio
496093 Xenopus laevis
100465620 Ailuropoda melanoleuca
100603832 Nomascus leucogenys
54552 Homo sapiens
507679 Bos taurus
237107 Mus musculus
100034253 Rattus norvegicus
480933 Canis lupus familiaris
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