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The protein encoded by GNL3L appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Additionally we are shipping GNL3L Antibodies (56) and GNL3L Kits (3) and many more products for this protein.
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the present study provides evidence that GNL3L is exported from the nucleus in CRM1 dependent manner and the nuclear localization of GNL3L is important to promote 'S' phase progression during cell proliferation.
GNL3L depletion impairs ribosome production without inducing appreciable DNA damage. During evolution, GNL3L retained the role of the ancestral gene in ribosome biosynthesis, whereas the paralogous nucleostemin (show E2IG3 Proteins) acquired a novel genome-protective function.
differences in the relative nucleostemin (show E2IG3 Proteins) protein and mRNA levels may reflect the degree of proliferation of mesnchymal stem cells and can be used to characterize in vitro expansion capabilities
GNL3L bound MDM2 (show MDM2 Proteins) in vivo, stabilizing MDM2 (show MDM2 Proteins) and preventing its ubiquitylation. GNL3L depletion upregulated specific p53 (show TP53 Proteins) targets (Bax (show BAX Proteins), 14-3-3sigma and p21 (show CDKN1A Proteins)).
analysis uncovers an important role for Grn1p/GNL3L within this unique group of nucleolar GTPases
GNL3L is composed of distinct modules, each of which plays a specific role in molecular interactions for its nucleolar retention and subsequent function(s) within the nucleolus
work reveals a novel mechanism that negatively regulates the transcriptional function of ERRgamma (estrogen-related receptor (show ESRRG Proteins))by GNL3L through coactivator competition.
GNL3L mediates the mitotic increase of TRF1 (show TERF1 Proteins) protein and promotes the metaphase-to-anaphase transition.
The protein encoded by this gene appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Two transcript variants encoding the same protein have been found for this gene.
guanine nucleotide-binding protein-like 3-like protein
, guanine nucleotide binding protein-like 3 (nucleolar)-like
, guanine nucleotide-binding protein-like 3-like protein-like
, novel GTPase