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The protein encoded by E2IG3 may interact with p53 and may be involved in tumorigenesis. Additionally we are shipping Guanine Nucleotide Binding Protein-Like 3 (Nucleolar) Antibodies (136) and Guanine Nucleotide Binding Protein-Like 3 (Nucleolar) Kits (3) and many more products for this protein.
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The nucleolar GTP-binding (show RND2 Proteins) proteins Gnl2 (show GNL2 Proteins) and nucleostemin are required for retinal neurogenesis in developing zebrafish.
In addition, migration and invasion demonstrated significant inhibition in Nucleostemin-deficient cells. Furthermore, the knockdown of Nucleostemin dramatically suppressed xenograft progression in BALB/c nude mice. Our findings suggest that Nucleostemin is associated with malignancy in an ovarian cancer SKOV-3 cell line.
Identified a positive correlation between up-regulation of nucleostemin and human glioma cell proliferation and that knocking-down nucleostemin alleviated glioma proliferation by reducing beta-Catenin (show CTNNB1 Proteins) transportation into the nucleus.
Relative expression of GNL3 in synovial tissue and fluid samples was significantly higher in the osteoarthritic group as compared to the non-osteoarthritic group.
The expression level of GNL3 was examined in 89 human gastric cancer samples using immunohistochemistry (IHC) staining. GNL3 in gastric cancer tissues was significantly upregulated compared with paracancerous tissues.
over-expression of GNL3 and SKA3 (show SKA3 Proteins) in the PC-3 (show PCSK1 Proteins) human prostate cancer cell line decreased in vitro cell migration and invasion
p53 (show TP53 Proteins) activation by inauhzin via inhibiting SIRT1 (show SIRT1 Proteins), also inhibits cellular IMPDH2 (show IMPDH2 Proteins) activity, reduces the levels of cellular GTP (show AK3 Proteins) and GTP-binding (show RND2 Proteins) nucleostemin, thus representing in a new anti-cancer strategy.
overexpression of NS suppressed ARF polyubiquitination by its E3 ligase Ubiquitin Ligase for ARF and elongated its half-life, whereas knockdown of NS led to the decrease of ARF levels
Silence of nucleostemin inhibit cell proliferation through up-regulating p21 (show CDKN1A Proteins) expression and nucleostemin may be involved in the pathogenesis of esophageal squamous cell carcinoma.
It is concluded that nucleostemin expression could not be specific in a certain type of cells in colon cancer cell line HT29.
Data shows that the NS protein expression status was positively correlated with both ER and HER2 (show ERBB2 Proteins) status and was a powerful prognostic factor.
Nucleostemin expression participates in the preservation of the viability and integrity of embryonic stem cells.
nucleostemin protects hematopoietic stem cells (HSCs) from DNA damage accumulation and is required for the maintenance of HSCs.
Mechanistic studies performed in mouse embryonic fibroblast cells showed that loss of nucleostemin triggers DNA damage and growth arrest independently of the p53 (show TP53 Proteins) status or rRNA synthesis
Nucleostemin in the maintenance of ESC self-renewal, demonstrate the importance of rapid transit through G1 for this process, and expand the known classes of reprogramming factors.
NS functions downstream of Myc (show MYC Proteins) as a rate-limiting regulator of cell proliferation and transformation.
NS undergoes a ubiquitin- and MDM2 (show MDM2 Proteins)-independent proteasomal degradation when intracellular GTP (show AK3 Proteins) levels are markedly reduced
a complex composed of TERT (show TERT Proteins), BRG1 (show SMARCA4 Proteins), and NS/GNL3L (show GNL3L Proteins) maintains the function of tumor initiating cells
Reactive oxygen species regulate nucleostemin oligomerization and protein degradation.
analysis of nucleolar localization of stem cell protein (show TAL1 Proteins) nucleostemin
Nucleostemin has a unique ability, derived from an ancestral function, to control the proliferation rate of stem/progenitor cells in vivo independently of p53.
Nucleostemin functions in early amphibian development to control cell proliferation of neural progenitor cells.
The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene.
guanine nucleotide-binding protein-like 3
, nucleostemin-like protein
, guanine nucleotide binding protein-like 3 (nucleolar)
, guanine nucleotide-binding protein-like 3-like
, E2-induced gene 3 protein
, estradiol-induced nucleotide binding protein
, novel nucleolar protein 47
, nucleolar GTP-binding protein 3