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Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. Additionally we are shipping GMPR2 Proteins (14) and GMPR2 Kits (3) and many more products for this protein.
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Loss of expression of GMPR2 and PPARalpha (show PPARA Antibodies) is associated with breast cancer basal phenotype; indicating that they may play a role in carcinogenesis.
A single crystal structure of human GMPR (show GMPR Antibodies) type 2 with IMP (show IMPA1 Antibodies) and NADPH (show NQO1 Antibodies) fortuitously captures three different states, each of which mimics a distinct step in the catalytic cycle of guanosine monophosphate reductase(GMPR (show GMPR Antibodies)).
Data suggest the existence of two distinct types of human GMP (show NT5C2 Antibodies) reductase molecular species, which can be used to explain the bimodal saturation curve noted with purified human erythrocyte GMP (show NT5C2 Antibodies) reductase.
GMPR2 is a novel human GMP (show NT5C2 Antibodies) reductase, and overexpression of GMPR2 can promote the monocytic differentiation of HL-60 leukemia cells.
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Plays a role in modulating cellular differentiation (By similarity).
guanosine monophosphate reductase 2
, GMP reductase 2
, guanosine 5'-monophosphate oxidoreductase 2
, guanosine monophosphate reductase isolog
, GMP reductase 2 (Guanosine 5-monophosphate oxidoreductase 2) (Guanosine monophosphate reductase 2)