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HBS1L encodes a member of the GTP-binding elongation factor family. Additionally we are shipping HBS1-Like (S. Cerevisiae) Antibodies (69) and many more products for this protein.
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we find that the interaction of UPF2 with UPF3b interferes with the assembly of the UPF2-eRF3 complex, and that UPF2 binds UPF3b more strongly than eRF3
eRF3 neither interacts with the rRNA ribosephosphate backbone nor dissociates from the complex after GTP (show AK3 Proteins) hydrolysis at translation termination.
The study compares polymorphism at BCL11A (show BCL11A Proteins) to HBS1L-MYB (show MYB Proteins) loci and explains less of the variance in HbF in patients with sickle cell disease in Cameroon.
Genetic variants of HBS1L is associated with sickle cell disease.
Several HBS1L-MYB (show MYB Proteins) intergenic variants reduce transcription factor binding, affecting interactions with MYB (show MYB Proteins) and MYB (show MYB Proteins) expression levels. This may explain the genetic association of HBS1L-MYB (show MYB Proteins) intergenic polymorphisms with erythroid traits and HbF levels.
The non-stop (show USP22 Proteins) decay mechanism exists in mammalian cells and involves Hbs1, Dom34, and the exosome-Ski (show SKI Proteins) complex.
Studies indicate that single nucleotide polymorphisms (SNPs) in regions of BCL11A (show BCL11A Proteins) and HBS1L-MYB (show MYB Proteins) intergenic polymorphism are the major modifiers of HbF in African Americans.
A 3-bp deletion in the HBS1L-MYB (show MYB Proteins) intergenic region on chromosome 6q23 is associated with HbF expression.
Pelota/Hbs1 induced dissociation of elongation complexes from ribosomes and release of peptidyl-tRNA, but only in the presence of ABCE1 (show ABCE1 Proteins).
crystal structures of the MLLE domain from PABPC1 in complex with the two PAM2 regions of eRF3
This gene encodes a member of the GTP-binding elongation factor family. It is expressed in multiple tissues with the highest expression in heart and skeletal muscle. The intergenic region of this gene and the MYB gene has been identified to be a quantitative trait locus (QTL) controlling fetal hemoglobin level, and this region influnces erythrocyte, platelet, and monocyte counts as well as erythrocyte volume and hemoglobin content. DNA polymorphisms at this region associate with fetal hemoglobin levels and pain crises in sickle cell disease. A single nucleotide polymorphism in exon 1 of this gene is significantly associated with severity in beta-thalassemia/Hemoglobin E. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
HBS1-like (S. cerevisiae)
, HBS1-like protein
, ef-1 alpha
, elongation factor 1-alpha
, ERF3-similar protein
, Hsp70 subfamily B suppressor 1-like protein
, eukaryotic release factor 3