HBS1-Like (S. Cerevisiae) Proteins (HBS1L)

HBS1L encodes a member of the GTP-binding elongation factor family. Additionally we are shipping HBS1-Like (S. Cerevisiae) Antibodies (72) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HBS1L 10767 Q9Y450
HBS1L 56422 Q69ZS7
Rat HBS1L HBS1L 293408 Q6AXM7
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Top HBS1-Like (S. Cerevisiae) Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days

HBS1L Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

More Proteins for HBS1-Like (S. Cerevisiae) (HBS1L) Interaction Partners

Human HBS1-Like (S. Cerevisiae) (HBS1L) interaction partners

  1. Knowledge of the interacting residues in the yeast complexes allowed identification of a splice variant of human HBS1-Like as a Ski7-like exosome-binding protein, revealing the evolutionary conservation of this cytoplasmic cofactor.

  2. high-risk genotypes of six Hb F-associated SNPs, rs9376090, rs7776054, rs9399137, rs9389268, rs9402685 in the HBS1L-MYB (show MYB Proteins) intergenic region and rs189984760 in the BCL11A (show BCL11A Proteins) locus, showed association with high Hb F levels

  3. The HBS1L-MYB (show MYB Proteins) region contains two HbF QTLs, HMIP (show MIPEP Proteins)-2A and HMIP (show MIPEP Proteins)-2B (HBS1L-MYB (show MYB Proteins) intergenic polymorphisms A and B) HMIP (show MIPEP Proteins)-A is tagged by the SNP rs9399137, with the C" allele promoting HbF. Only 1 sickle cell patient had this allele. HMIP (show MIPEP Proteins)-B was tagged in these patients by rs4895441and represented Amerindian ethnic origin.

  4. we find that the interaction of UPF2 with UPF3b interferes with the assembly of the UPF2-eRF3 complex, and that UPF2 binds UPF3b more strongly than eRF3

  5. eRF3 neither interacts with the rRNA ribosephosphate backbone nor dissociates from the complex after GTP (show AK3 Proteins) hydrolysis at translation termination.

  6. The study compares polymorphism at BCL11A (show BCL11A Proteins) to HBS1L-MYB (show MYB Proteins) loci and explains less of the variance in HbF in patients with sickle cell disease in Cameroon.

  7. Genetic variants of HBS1L is associated with sickle cell disease.

  8. Several HBS1L-MYB (show MYB Proteins) intergenic variants reduce transcription factor binding, affecting interactions with MYB (show MYB Proteins) and MYB (show MYB Proteins) expression levels. This may explain the genetic association of HBS1L-MYB (show MYB Proteins) intergenic polymorphisms with erythroid traits and HbF levels.

  9. The non-stop (show USP22 Proteins) decay mechanism exists in mammalian cells and involves Hbs1, Dom34, and the exosome-Ski (show SKI Proteins) complex.

  10. Studies indicate that single nucleotide polymorphisms (SNPs) in regions of BCL11A (show BCL11A Proteins) and HBS1L-MYB (show MYB Proteins) intergenic polymorphism are the major modifiers of HbF in African Americans.

HBS1-Like (S. Cerevisiae) (HBS1L) Protein Profile

Protein Summary

This gene encodes a member of the GTP-binding elongation factor family. It is expressed in multiple tissues with the highest expression in heart and skeletal muscle. The intergenic region of this gene and the MYB gene has been identified to be a quantitative trait locus (QTL) controlling fetal hemoglobin level, and this region influnces erythrocyte, platelet, and monocyte counts as well as erythrocyte volume and hemoglobin content. DNA polymorphisms at this region associate with fetal hemoglobin levels and pain crises in sickle cell disease. A single nucleotide polymorphism in exon 1 of this gene is significantly associated with severity in beta-thalassemia/Hemoglobin E. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.

Gene names and symbols associated with HBS1L

  • HBS1-like (S. cerevisiae) (HBS1L)
  • HBS1-like protein (SJAG_02601)
  • HBS1-like (S. cerevisiae) (hbs1l)
  • eukaryotic translation elongation factor 1 alpha 1, like 1 (eef1a1l1)
  • HBS1-like (hbs1l)
  • Hbs1-like (S. cerevisiae) (Hbs1l)
  • 2810035F15Rik protein
  • AI326327 protein
  • chunp6927 protein
  • eef1a protein
  • EF-1a protein
  • ef1a protein
  • EFL1-alpha protein
  • eRFS protein
  • HBS1 protein
  • HSPC276 protein
  • ik:tdsubc_2a3 protein
  • ik:tdsubc_2b3 protein
  • tdsubc_2a3 protein
  • wu:fa91c07 protein
  • wu:fa94b03 protein
  • wu:fc23c07 protein
  • wu:fi13b09 protein
  • xx:tdsubc_2a3 protein
  • xx:tdsubc_2b3 protein
  • zgc:55400 protein

Protein level used designations for HBS1L

HBS1-like (S. cerevisiae) , HBS1-like protein , EF-1-alpha , ef-1 alpha , elongation factor 1-alpha , ERF3-similar protein , Hsp70 subfamily B suppressor 1-like protein , eukaryotic release factor 3

463015 Pan troglodytes
7047708 Schizosaccharomyces japonicus yFS275
100173449 Pongo abelii
100195249 Salmo salar
30516 Danio rerio
444278 Xenopus laevis
324267 Danio rerio
421694 Gallus gallus
10767 Homo sapiens
476211 Canis lupus familiaris
541083 Bos taurus
56422 Mus musculus
293408 Rattus norvegicus
100155814 Sus scrofa
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