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HUWE1 encodes a member of the HECT E3 ubiquitin ligase family. Additionally we are shipping HUWE1 Antibodies (69) and HUWE1 Proteins (2) and many more products for this protein.
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The authors show that HUWE1 dimerizes in solution and self-associates in cells, and that both occurs through the crystallographic dimer interface. They also demonstrate that HUWE1 is inhibited in cells and that it can be activated by disruption of the dimer interface.
High HUWE1 expression is associated with Ovarian cancer.
It has been shown that mitofusin-2 is modified with K6-linked polyubiquitin in a HUWE1-dependent manner.
HUWE1 is essential for genomic stability, by promoting replication of damaged DNA We show that HUWE1-knockout cells are unable to mitigate replication stress, resulting in replication defects and DNA breakage.
N-myc expression was upregulated in response to stress or following loss of Huwe1, which led to increased proliferation and stem-cell exhaustion.
The interaction with Huwe1 and polyubiquitylation were blocked by disruption of casein kinase 1 (CK1 (show CSNK1A1 ELISA Kits)) activity, and mass spectrometry and mutational analysis identified serine 334 as an important phosphorylation site for Atoh1 (show ATOH1 ELISA Kits) ubiquitylation and subsequent degradation.
Elevated HECTH9 protein expression is associated with pathogenesis of hepatocellular carcinoma.
Mechanistic investigation revealed that HUWE1 can regulate p53 protein level through its stabilization. HUWE1 functions as a tumour suppressor in thyroid cancer progression, which may represent a novel therapeutic target for prevention or intervention of thyroid cancer.
We identified a HUWE1 mutation in an affected male with Juberg-Marsidi and Brooks syndromes from the original family reported by Juberg and Marsidi; it is evident the syndrome does not result from a mutation in ATRX as reported in the literature. Additionally, the data indicated that Juberg-Marsidi syndrome and Brooks syndromes are allelic having the same HUWE1 mutation.
Results reveal a pathway controlled by ATM, SIRT6, and SNF2H to block HUWE1, which stabilizes H2AX and induces its incorporation into chromatin only when cells are damaged.
Taken together, these data identify HUWE1 as a bona fide tumour suppressor gene in the intestinal epithelium and suggest a potential vulnerability of HUWE1-mutated tumours to DNA-damaging agents and inhibitors of anti-apoptotic proteins.
Mule also regulates protein levels of the receptor tyrosine kinase (show ERBB3 ELISA Kits) EphB3 (show EPHB3 ELISA Kits) by targeting it for proteasomal and lysosomal degradation.
this study shows that the E3-ubiquitin ligase Huwe1 (HECT, UBA, and WWE domain-containing 1) is required for proliferating stem cells of the adult mouse hippocampus to return to quiescence.
TNF (show TNF ELISA Kits) activates Mule by inducing the dissociation of Mule from its inhibitor ARF. Inhibition of Mule phosphorylation by silencing Syk (show SYK ELISA Kits) prevents this, thereby inhibiting Mule E3 ligase activity and TNF (show TNF ELISA Kits)-induced JNK (show MAPK8 ELISA Kits) activation and cell death.
expression level of miR (show MLXIP ELISA Kits)-98, which can regulate Caspase-3 (show CASP3 ELISA Kits), was significantly decreased. Huwe1, the host gene of miR (show MLXIP ELISA Kits)-98, was positively associated with miR (show MLXIP ELISA Kits)-98 expression after Silica NP exposure
Thus, modulating the levels of both Huwe1 and USP10 (show USP10 ELISA Kits) appears to fine-tune the requisite degradation of TBP (show TBP ELISA Kits) during myogenesis.
Results show that ARF-BP1 was expressed at high levels in B-cell lymphoma cell lines and by regulating MYC and p53 transcriptional activity, ARF-BP1 is a critical determinant of the proliferation of B cell lymphomas.
The dynamic balance between MYC and p53 required for normal B cell maturation and function is finely tuned and critically dependent on the activities of ARF-BP1.
data demonstrate in vivo that Mule suppresses Ras-mediated tumorigenesis by preventing an accumulation of c-Myc (show MYC ELISA Kits)/Miz1 (show PIAS2 ELISA Kits) complexes that mediates p21 and p15 (show CDKN2B ELISA Kits) down-regulation
an important role of ARF-BP1 in maintaining beta-cell homeostasis in aging mice and reveal that the stability of p53 is critically regulated by ARF-BP1 in vivo.
E3Histone is therefore a HECT domain E3 that likely plays an important role in the chromatin condensation
This gene encodes a member of the HECT E3 ubiquitin ligase family. The HECT domain lies in the C-terminus and contains the active-site cysteine which forms an intermediate ubiquitin-thioester bond. E3 family members are divided into three subfamilies based on their protein-protein interaction domains\; this gene encodes a member of the SI(ngle)-HECT E3 subfamily. In lung, breast, and colorectal carcinomas, this gene is highly expressed. Mutations in this gene has been found in 3 unrelated families with X-linked syndromic mental retardation, Turner type.
ARF-binding protein 1
, BJ-HCC-24 tumor antigen
, E3 ubiquitin-protein ligase HUWE1
, HECT domain protein LASU1
, Mcl-1 ubiquitin ligase E3
, URE-binding protein 1
, homologous to E6AP carboxyl terminus homologous protein 9
, large structure of UREB1
, upstream regulatory element-binding protein 1
, HECT, UBA and WWE domain-containing protein 1
, Mcl-1 ubiquitin ligase
, upstream regulatory element binding protein 1
, HECT, UBA and WWE domain containing 1
, e3 ubiquitin-protein ligase HUWE1-like