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The protein encoded by HSPB8 belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. Additionally we are shipping Heat Shock 22kDa Protein 8 Proteins (30) and Heat Shock 22kDa Protein 8 Kits (12) and many more products for this protein.
Showing 10 out of 153 products:
Human Monoclonal HSPB8 Primary Antibody for ICC, IF - ABIN863103
Sun, Fontaine, Rest, Shelden, Welsh, Benndorf: Interaction of human HSP22 (HSPB8) with other small heat shock proteins. in The Journal of biological chemistry 2004
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Human Monoclonal HSPB8 Primary Antibody for ICC, IF - ABIN2484237
Kappé, Verschuure, Philipsen, Staalduinen, Van de Boogaart, Boelens, De Jong: Characterization of two novel human small heat shock proteins: protein kinase-related HspB8 and testis-specific HspB9. in Biochimica et biophysica acta 2001
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Human Monoclonal HSPB8 Primary Antibody for ICC, IF - ABIN2484234
Benndorf, Sun, Gilmont, Biederman, Molloy, Goodmurphy, Cheng, Andrews, Welsh: HSP22, a new member of the small heat shock protein superfamily, interacts with mimic of phosphorylated HSP27 ((3D)HSP27). in The Journal of biological chemistry 2001
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Human Monoclonal HSPB8 Primary Antibody for ICC, IF - ABIN2484238
Kim, Seit-Nebi, Gusev: The problem of protein kinase activity of small heat shock protein Hsp22 (H11 or HspB8). in Biochemical and biophysical research communications 2004
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Cow (Bovine) Polyclonal HSPB8 Primary Antibody for WB - ABIN2786018
Carra, Seguin, Landry: HspB8 and Bag3: a new chaperone complex targeting misfolded proteins to macroautophagy. in Autophagy 2008
It has been demonstrated that HSPB8-BAG3 (show BAG3 Antibodies)-HSP70 (show HSP70 Antibodies) ensures the functionality of stress granules and restores proteostasis by targeting defective ribosomal products for degradation.
We report that overexpression of HSPB8 in immortalized motor neurones decreased the accumulation of TDP-25 and TDP-35 and that protection against mislocalized/truncated TDP-43 (show TARDBP Antibodies) was observed for HSPB8 in Drosophila melanogaster Overexpression of HSP67Bc, the functional ortholog of human HSPB8, suppressed the eye degeneration caused by the cytoplasmic accumulation of a TDP-43 (show TARDBP Antibodies) variant
HSPB8 counteracts accumulation of aberrantly localized misfolded forms of TDP-43 (show TARDBP Antibodies) and its 25 KDa fragment involved in most sporadic cases of Amyotrophic Lateral Sclerosis and of Fronto Lateral Temporal Dementia.
expands the understanding of disease mechanisms, tissue involvement, and phenotypic outcome of HSPB8 mutations
our findings suggest the existence of a so-far unrecognized quality control mechanism involving BAG3 (show BAG3 Antibodies), HSPB8 and p62/SQSTM1 (show SQSTM1 Antibodies) for accurate remodelling of actin-based mitotic structures that guide spindle orientation.
This study demonstreated that expression of HSPB8 was restricted to GFAP (show GFAP Antibodies)+ astrocytes in patient with multiple sclerosis.
Pangenomic profiling of velcade-sensitive and resistant cells showed that the small heat shock protein HSPB8 was overexpressed in multiple myeloma resistant cells.
HSP22 acts as a positive regulator in TGF-alpha (show TGFA Antibodies)-induced migration of ovarian cancer cells, subsequently directing ovarian cancer toward progression.
HSP22 plays an important role on gastric tumor aggressiveness and prognosis and may act as a promising target for prognostic prediction.
Mutant HSPB8 causes protein aggregates and a reduced mitochondrial membrane potential in dermal fibroblasts from distal hereditary motor neuropathy patients.
GA genotype of SNP g.507G>A of HSPB8 gene has a probable role in heat tolerance in Sahiwal cattle.
Results revealed that the apoptosis-suppressing effect of heat shock protein B8 was mediated by the PI3K/Akt (show AKT1 Antibodies) pathway in an in vitro model of ischemia.
Increased Hsp20 (show HSPB6 Antibodies) expression protects against OGDR-induced Golgi fragmentation and apoptosis, likely through interaction with Bax (show BAX Antibodies) and subsequent amelioration of the OGDR-induced elevation in p115 (show ARHGAP4 Antibodies) cleavage via the Fas (show FAS Antibodies)/FasL (show FASL Antibodies) signaling pathway.
Translocation of both Hsp22 and iNOS to the mitochondria is necessary for Hsp22-mediated stimulation of oxidative phosphorylation
analysis of the phenotype of cardiomyopathy in cardiac-specific heat shock protein B8 K141N transgenic mouse
The results of this study strongly suggested that Hspb8 and its alpha-crystallin domain might act as pleiotropic prosurvival factor in the adult hippocampus.
Hspb8 mRNA is constitutively expressed in specific brain structures across ontogeny; eventually these structures could be affected by the malfunction or deregulation of the Hspb8 molecule.
Hsp22 represents a previously undescribed activator of both nuclear and mitochondrial functions of STAT3 (show STAT3 Antibodies), and its deletion in the context of pressure overload in vivo accelerates the transition into heart failure and increases mortality.
HspB8 increases misfolded SOD1 (show SOD1 Antibodies) clearance via autophagy.
Findings show that despite the ubiquitous presence of HSPB8, only motor neurons appear to be affected by the K141N and K141E mutations.
H11 kinase promotes the synthesis of glycogen (show GYS1 Antibodies), an essential fuel for the stressed heart in both conditions of overload and ischemia
The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease.
heat shock 22kDa protein 8
, heat shock 27kDa protein 8
, heat shock protein beta-8
, E2-induced gene 1 protein
, alpha-crystallin C chain
, protein kinase H11
, small stress protein-like protein HSP22
, H11 kinase
, crystallin, alpha C
, heat shock protein 20-like protein
, heat shock protein 8