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HMCN1 encodes a large extracellular member of the immunoglobulin superfamily. Additionally we are shipping Hemicentin 1 Kits (3) and many more products for this protein.
Showing 5 out of 5 products:
mutant and dose-dependent interaction data suggest a potential involvement of Hmcn1 in Fraser complex-dependent basement membrane anchorage
A null-variant in HMCN1 (c.4162delC), has been identified in a Tunisian Jewish family with early-onset age-related macular degeneration.
HMCN1 mutation is associated with gastric and colorectal cancers.
Fibulin-6, a fibroblast-released extracellular matrix protein, may play an important role during myocardial remodelling by imparting an effect on cardiac fibroblasts migration in close and complementary interplay with TGF-beta1 (show TGFB1 Antibodies) signalling
The identified variants of HMCN1 are on conserved domains, particularly the two variants on calcium-binding epidermal growth factor (show EGF Antibodies) domain.
this is the first association study based on a candidate gene approach to confirm that a HMCN1 polymorphism (rs2891230) is associated with postpartum depression diagnosis. heterozygosity (GA) for this SNP was associated with an increased risk of PPD (show HPD Antibodies).
Constructs show that EGF (show EGF Antibodies) repeats 4 and 5 are required for hemicentin-dependent assembly and function of transgenic fibulin-1D (show FBLN1 Antibodies) in native locations.
We mapped the ARMD1 gene. Identification of the genes involved in AMD (show AMD1 Antibodies) will lead to a better understanding of this disease at the molecular level.
None of our subjects (258 macular degeneration,AMD (show AMD1 Antibodies), cases, 72 non-AMD (show AMD1 Antibodies) controls) had the Gln5345Arg variant in the HMCN1 gene.
We were not able to demonstrate an association between the Hemicentin-1, hOgg1, and E-selectin (show SELE Antibodies) SNPs and age-related macular degeneration development in the currently available cases and controls.
The CFH (show CFH Antibodies) gene and Hemicentin-1 genes do not appear to be involved in a statistically significant fraction of dry AMD (show AMD1 Antibodies) (age-related macular degeneration) cases in the Japanese population.
This study showed that extracellular hemicentin-1[Hmcn1] assemble at the cleavage furrow of dividing cells in the C. elegans germline and in preimplantation mouse embryos.
This gene encodes a large extracellular member of the immunoglobulin superfamily. A similar protein in C. elegans forms long, fine tracks at specific extracellular sites that are involved in many processes such as stabilization of the germline syncytium, anchorage of mechanosensory neurons to the epidermis, and organization of hemidesmosomes in the epidermis. Mutations in this gene may be associated with age-related macular degeneration.
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