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anti-Hemopoietic Cell Kinase (HCK) Antibodies

The protein encoded by HCK is a member of the Src family of tyrosine kinases. Additionally we are shipping HCK Proteins (10) and HCK Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
HCK 3055 P08631
HCK 15162 P08103
HCK 25734 P50545
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Top anti-HCK Antibodies at antibodies-online.com

Showing 10 out of 138 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated FACS, IHC (p), WB HCK Antibody (N-term) (ABIN652384) western blot analysis in mouse lung tissue lysates (15 µg/lane).This demonstrates the HCK antibody detected HCK protein (arrow). HCK Antibody (N-term) (ABIN652384) immunohistochemistry analysis in formalin fixed and paraffin embedded human spleen tissue followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IF, ELISA Immunofluorescence analysis of HeLa cells, using HCK (Phospho-Tyr410) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated WB HCK Antibody (E8) (ABIN392099) western blot analysis in human placenta tissue lysates (35 µg/lane).This demonstrates the HCK antibody detected the HCK protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IF, IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human brain tissue, using HCK (Ab-410) Antibody Antibody. The picture on the right is treated with the synthesized peptide. Immunofluorescence analysis of HepG2 cells, using HCK (Ab-410) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Dog Mouse Un-conjugated IF, IP, IHC, WB Western blot analysis of Hck on a MDCK cell lysate (Canine kidney, ATCC CCL-34). Lane 1: 1:1000, lane 2: 1:2000, lane 3: 1:4000 dilution of the mouse anti- Hck antibody. Immunofluorescence staining of MDCK cells (Canine kidney, ATCC CCL-34). 50 μg Log in to see 5 to 6 Days
$205.42
Details
Human Mouse Un-conjugated IHC, ELISA, WB Figure 1: Immunohistochemical analysis of paraffin-embedded human colon cancer (left) and ancreas cancer (right), showing cytoplasmic localization using HCK mouse mAb with DAB staining. Figure 2: Western blot analysis using HCK mouse mAb against truncated HCK recombinant protein (1) and full-length HCK-GFP transfected CHO-K1 cell lysate (2) . 100 μL Log in to see 3 to 4 Days
$442.20
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-HCK AntibodyTitration: 1.0 µg/mL  Positive Control: Fetal Thymus 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated IHC, WB   100 μL Log in to see 10 to 11 Days
$550.00
Details
Human Rabbit Un-conjugated WB Mouse Hck Antibody (N-term)  western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the Hck antibody detected the Hck protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details

HCK Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-HCK Antibodies

  1. Dog (Canine) Monoclonal HCK Primary Antibody for IF, IP - ABIN967877 : Baumgartner, Angelisová, Setterblad, Mooney, Werling, Horejsí, Langsley: Constitutive exclusion of Csk from Hck-positive membrane microdomains permits Src kinase-dependent proliferation of Theileria-transformed B lymphocytes. in Blood 2003 (PubMed)
    Show all 5 references for ABIN967877

  2. Human Polyclonal HCK Primary Antibody for EIA, WB - ABIN359984 : Komuro, Yokota, Yasuda, Iwamoto, Kagawa: CSF-induced and HIV-1-mediated distinct regulation of Hck and C/EBPbeta represent a heterogeneous susceptibility of monocyte-derived macrophages to M-tropic HIV-1 infection. in The Journal of experimental medicine 2003 (PubMed)
    Show all 4 references for ABIN359984

  3. Human Polyclonal HCK Primary Antibody for FACS, IHC (p) - ABIN652384 : Hassan, Suzu, Hiyoshi, Takahashi-Makise, Ueno, Agatsuma, Akari, Komano, Takebe, Motoyoshi, Okada: Dys-regulated activation of a Src tyroine kinase Hck at the Golgi disturbs N-glycosylation of a cytokine receptor Fms. in Journal of cellular physiology 2009 (PubMed)
    Show all 3 references for ABIN652384

  4. Human Monoclonal HCK Primary Antibody for IHC, ELISA - ABIN969187 : Schnoor: What I learned in Europe.... in Environmental science & technology 2007 (PubMed)
    Show all 2 references for ABIN969187

  5. Human Polyclonal HCK Primary Antibody for IF, ELISA - ABIN1531606 : Deloukas, Matthews, Ashurst, Burton, Gilbert, Jones, Stavrides, Almeida, Babbage, Bagguley, Bailey, Barlow, Bates, Beard, Beare, Beasley, Bird, Blakey, Bridgeman, Brown, Buck, Burrill, Butler, Carder et al.: The DNA sequence and comparative analysis of human chromosome 20. ... in Nature 2002 (PubMed)
    Show all 2 references for ABIN1531606

  6. Human Polyclonal HCK Primary Antibody for WB - ABIN392099 : Stanglmaier, Warmuth, Kleinlein, Reis, Hallek: The interaction of the Bcr-Abl tyrosine kinase with the Src kinase Hck is mediated by multiple binding domains. in Leukemia 2003 (PubMed)
    Show all 2 references for ABIN392099

  7. Human Monoclonal HCK Primary Antibody for IHC, WB - ABIN2869274 : Selimoglu, Ertekin, Altinkaynak: Hyper-CK-emia in pediatric celiac disease: prevalence and clinical importance. in Journal of clinical gastroenterology 2007 (PubMed)

More Antibodies against HCK Interaction Partners

Human Hemopoietic Cell Kinase (HCK) interaction partners

  1. we provide evidence for involvement of HCK and FGR (show FGR Antibodies) in FCRL4 (show FCRL4 Antibodies)-mediated immunoregulation and for the functional importance of posttranslational modifications of the FCRL4 (show FCRL4 Antibodies) molecule.

  2. Interaction with the Src (show SRC Antibodies) homology (SH3-SH2) region of the Hck structures the HIV-1 Nef dimer for kinase activation and effector recruitment.

  3. Interaction between Nef and Hck is important for Nef-dependent modulation of viral infectivity.

  4. Data indicate that combined treatment using SFK (LYN (show LYN Antibodies), HCK, or FGR (show FGR Antibodies)) and c-KIT (show KIT Antibodies) inhibitor dasatinib dasatinib and chemotherapy provides a novel approach to increasing p53 (show TP53 Antibodies) activity and enhancing targeting of acute myeloid leukemia (show BCL11A Antibodies) (AML (show RUNX1 Antibodies)) stem cells.

  5. The SRC (show SRC Antibodies) family tyrosine kinase (show TXK Antibodies) HCK and the ETS (show ETS1 Antibodies) family transcription factors SPIB (show SPIB Antibodies) and EHF (show EHF Antibodies) regulate transcytosis across a human follicle-associated epithelium model.

  6. This particular binding mode enables Hck SH3 to sense a specific non-canonical residue situated in the SH3 RT-loop of the kinase.

  7. the activation of Hck, Lyn and c-Src by Nef is highly conserved among all major clades of HIV-1

  8. There were significant differences in the genotype and allele distribution of -627 G/T polymorphism in Hck gene between cases and controls.

  9. Hck activation at the Golgi apparatus causes the HIV-1 Nef-induced c-Fms (show CSF1R Antibodies) proto-oncogene (show CSF1R Antibodies) N-glycosylation defect.

  10. Loss of HCK is associated with acute promyelocytic leukemia (show PML Antibodies).

Mouse (Murine) Hemopoietic Cell Kinase (HCK) interaction partners

  1. Data indicate that Src (show SRC Antibodies)-Family Kinases Hck and Fgr (show FGR Antibodies) regulate cytokine secretion by macrophages.

  2. Hck is not only progressively overexpressed in atherosclerosis, but it also controls critical molecular processes in monocyte influx, blood monocyte subset balance, macrophage accumulation, and the maintenance of atherosclerotic lesion stability.

  3. The Src (show SRC Antibodies) family kinases Hck, Fgr (show FGR Antibodies), and Lyn (show LYN Antibodies) are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment.

  4. tyrosine phosphorylation of WASP (show WASL Antibodies) by Hck is required for proper macrophage functions

  5. Hck is one of the very few effectors of preosteoclast recruitment described to date and thereby plays a critical role in bone remodeling.

  6. Despite possessing enhanced killing, alveolar macrophage Hck/Fgr (show FGR Antibodies)/Lyn (show LYN Antibodies)-deficient ("triple-knockout") mice do not demonstrate enhanced inflammatory responses to Pneumocystis murina.

  7. Taken together, PKR (show EIF2AK2 Antibodies) and Hck were critical for DON-induced ribosomal recruitment of p38 (show CRK Antibodies), its subsequent phosphorylation, and, ultimately, p38 (show CRK Antibodies)-driven proinflammatory cytokine expression.

  8. Nef participates in HIV-1-induced multinucleated giant cells formation via a p61Hck- and lysosomal enzyme-dependent pathway

  9. spatial organization of podosomes as large rosettes, proteolytic degradation of extracellular matrix, and 3D migration appeared to be functionally linked and regulated by Hck in macrophages

  10. enhanced innate immune response in Hck(F/F) mice thereby skewing innate immunity from a reversible physiological host defense response to one causing irreversible tissue damage

Cow (Bovine) Hemopoietic Cell Kinase (HCK) interaction partners

  1. A truncated, mRNA-encoded src-related tyrosine kinase (show FRK Antibodies) HCK could function as an adaptor protein or as a competitive inhibitor in spermiogenesis or mature sperm functions.

  2. the presence of mRNAs encoding for hck and hck-tr in testicular germ cells; hck-tr being translated during spermatogenesis and expressed on mature ejaculated bull spermatozoa.

HCK Antigen Profile

Protein Summary

The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon.

Gene names and symbols associated with HCK

  • hemopoietic cell kinase (tklal-a) antibody
  • hemopoietic cell kinase (HCK) antibody
  • hemopoietic cell kinase (hck) antibody
  • hemopoietic cell kinase (Hck) antibody
  • AI849071 antibody
  • Bmk antibody
  • HCK antibody
  • Hctk antibody
  • JTK9 antibody
  • laloo antibody
  • MGC107870 antibody
  • p56Hck antibody
  • p59Hck antibody
  • p61Hck antibody

Protein level used designations for HCK

hemopoietic cell kinase , non-receptor protein tyrosine kinase laloo , tyrosine-protein kinase HCK-like , hematopoietic cell kinase , p59-HCK/p60-HCK , tyrosine-protein kinase HCK , B cell/myeloid kinase , B-cell/myeloid kinase , p56-HCK/p59-HCK , hemopoietic cell tyrosine kinase , p56-HCK

GENE ID SPECIES
373700 Xenopus laevis
458163 Pan troglodytes
485828 Canis lupus familiaris
548439 Xenopus (Silurana) tropicalis
100455620 Pongo abelii
100587780 Nomascus leucogenys
3055 Homo sapiens
15162 Mus musculus
25734 Rattus norvegicus
419280 Gallus gallus
280814 Bos taurus
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