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The protein encoded by HCK is a member of the Src family of tyrosine kinases. Additionally we are shipping HCK Proteins (10) and HCK Kits (4) and many more products for this protein.
Showing 10 out of 136 products:
Dog (Canine) Monoclonal HCK Primary Antibody for IF, IP - ABIN967877
Baumgartner, Angelisová, Setterblad, Mooney, Werling, Horejsí, Langsley: Constitutive exclusion of Csk from Hck-positive membrane microdomains permits Src kinase-dependent proliferation of Theileria-transformed B lymphocytes. in Blood 2003
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Human Polyclonal HCK Primary Antibody for EIA, WB - ABIN359984
Komuro, Yokota, Yasuda, Iwamoto, Kagawa: CSF-induced and HIV-1-mediated distinct regulation of Hck and C/EBPbeta represent a heterogeneous susceptibility of monocyte-derived macrophages to M-tropic HIV-1 infection. in The Journal of experimental medicine 2003
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Human Polyclonal HCK Primary Antibody for FACS, IHC (p) - ABIN652384
Hassan, Suzu, Hiyoshi, Takahashi-Makise, Ueno, Agatsuma, Akari, Komano, Takebe, Motoyoshi, Okada: Dys-regulated activation of a Src tyroine kinase Hck at the Golgi disturbs N-glycosylation of a cytokine receptor Fms. in Journal of cellular physiology 2009
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Human Monoclonal HCK Primary Antibody for IHC, ELISA - ABIN969187
Schnoor: What I learned in Europe.... in Environmental science & technology 2007
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Human Polyclonal HCK Primary Antibody for IF, ELISA - ABIN1531606
Deloukas, Matthews, Ashurst, Burton, Gilbert, Jones, Stavrides, Almeida, Babbage, Bagguley, Bailey, Barlow, Bates, Beard, Beare, Beasley, Bird, Blakey, Bridgeman, Brown, Buck, Burrill, Butler, Carder et al.: The DNA sequence and comparative analysis of human chromosome 20. ... in Nature 2002
Show all 2 references for ABIN1531606
Human Polyclonal HCK Primary Antibody for WB - ABIN392099
Stanglmaier, Warmuth, Kleinlein, Reis, Hallek: The interaction of the Bcr-Abl tyrosine kinase with the Src kinase Hck is mediated by multiple binding domains. in Leukemia 2003
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Human Monoclonal HCK Primary Antibody for IHC, WB - ABIN2869274
Selimoglu, Ertekin, Altinkaynak: Hyper-CK-emia in pediatric celiac disease: prevalence and clinical importance. in Journal of clinical gastroenterology 2007
we provide evidence for involvement of HCK and FGR (show FGR Antibodies) in FCRL4 (show FCRL4 Antibodies)-mediated immunoregulation and for the functional importance of posttranslational modifications of the FCRL4 (show FCRL4 Antibodies) molecule.
Interaction with the Src (show SRC Antibodies) homology (SH3-SH2) region of the Hck structures the HIV-1 Nef dimer for kinase activation and effector recruitment.
Interaction between Nef and Hck is important for Nef-dependent modulation of viral infectivity.
Data indicate that combined treatment using SFK (LYN (show LYN Antibodies), HCK, or FGR (show FGR Antibodies)) and c-KIT (show KIT Antibodies) inhibitor dasatinib dasatinib and chemotherapy provides a novel approach to increasing p53 (show TP53 Antibodies) activity and enhancing targeting of acute myeloid leukemia (show BCL11A Antibodies) (AML (show RUNX1 Antibodies)) stem cells.
The SRC (show SRC Antibodies) family tyrosine kinase (show TXK Antibodies) HCK and the ETS (show ETS1 Antibodies) family transcription factors SPIB (show SPIB Antibodies) and EHF (show EHF Antibodies) regulate transcytosis across a human follicle-associated epithelium model.
This particular binding mode enables Hck SH3 to sense a specific non-canonical residue situated in the SH3 RT-loop of the kinase.
the activation of Hck, Lyn and c-Src by Nef is highly conserved among all major clades of HIV-1
There were significant differences in the genotype and allele distribution of -627 G/T polymorphism in Hck gene between cases and controls.
Hck activation at the Golgi apparatus causes the HIV-1 Nef-induced c-Fms (show CSF1R Antibodies) proto-oncogene (show CSF1R Antibodies) N-glycosylation defect.
Loss of HCK is associated with acute promyelocytic leukemia (show PML Antibodies).
Data indicate that Src (show SRC Antibodies)-Family Kinases Hck and Fgr (show FGR Antibodies) regulate cytokine secretion by macrophages.
Hck is not only progressively overexpressed in atherosclerosis, but it also controls critical molecular processes in monocyte influx, blood monocyte subset balance, macrophage accumulation, and the maintenance of atherosclerotic lesion stability.
The Src (show SRC Antibodies) family kinases Hck, Fgr (show FGR Antibodies), and Lyn (show LYN Antibodies) are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment.
tyrosine phosphorylation of WASP (show WASL Antibodies) by Hck is required for proper macrophage functions
Hck is one of the very few effectors of preosteoclast recruitment described to date and thereby plays a critical role in bone remodeling.
Despite possessing enhanced killing, alveolar macrophage Hck/Fgr (show FGR Antibodies)/Lyn (show LYN Antibodies)-deficient ("triple-knockout") mice do not demonstrate enhanced inflammatory responses to Pneumocystis murina.
Taken together, PKR (show EIF2AK2 Antibodies) and Hck were critical for DON-induced ribosomal recruitment of p38 (show CRK Antibodies), its subsequent phosphorylation, and, ultimately, p38 (show CRK Antibodies)-driven proinflammatory cytokine expression.
Nef participates in HIV-1-induced multinucleated giant cells formation via a p61Hck- and lysosomal enzyme-dependent pathway
spatial organization of podosomes as large rosettes, proteolytic degradation of extracellular matrix, and 3D migration appeared to be functionally linked and regulated by Hck in macrophages
enhanced innate immune response in Hck(F/F) mice thereby skewing innate immunity from a reversible physiological host defense response to one causing irreversible tissue damage
A truncated, mRNA-encoded src-related tyrosine kinase (show FRK Antibodies) HCK could function as an adaptor protein or as a competitive inhibitor in spermiogenesis or mature sperm functions.
the presence of mRNAs encoding for hck and hck-tr in testicular germ cells; hck-tr being translated during spermatogenesis and expressed on mature ejaculated bull spermatozoa.
The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon.
hemopoietic cell kinase
, non-receptor protein tyrosine kinase laloo
, tyrosine-protein kinase HCK-like
, hematopoietic cell kinase
, tyrosine-protein kinase HCK
, B cell/myeloid kinase
, B-cell/myeloid kinase
, hemopoietic cell tyrosine kinase