HCK antibody (AA 324-505)

Catalog No. ABIN7267612

This Rabbit Polyclonal antibody specifically detects HCK in WB. It exhibits reactivity toward Human.

Quick Overview for HCK antibody (AA 324-505) (ABIN7267612)

Target: HCK (Hemopoietic Cell Kinase (HCK))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HCK antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-HCK Antibody

Binding Specificity: AA 324-505

Purpose: HCK Rabbit pAb

Sequence: LKSDEGSKQP LPKLIDFSAQ IAEGMAFIEQ RNYIHRDLRA ANILVSASLV CKIADFGLAR VIEDNEYTAR EGAKFPIKWT APEAINFGSF TIKSDVWSFG ILLMEIVTYG RIPYPGMSNP EVIRALERGY RMPRPENCPE ELYNIMMRCW KNRPEERPTF EYIQSVLDDF YTATESQYQQ QP

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 324-505 of human HCK (NP_001165600.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for HCK

Target: HCK (Hemopoietic Cell Kinase (HCK))

Alternative Name: HCK

Background: The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon.,HCK,JTK9,p59Hck,p61Hck,Signal Transduction,G protein signaling,G2/M DNA Damage Checkpoint,Kinase,Tyrosine kinases,Immunology & Inflammation,HCK

Molecular Weight: 57kDa/59kDa

Gene ID: 3055

UniProt: P08631

Pathways: Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling