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Hemopoietic Cell Kinase Proteins (HCK)

The protein encoded by HCK is a member of the Src family of tyrosine kinases. Additionally we are shipping HCK Antibodies (138) and HCK Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HCK 3055 P08631
HCK 15162 P08103
HCK 25734 P50545
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Top HCK Proteins at

Showing 9 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Baculovirus infected Insect Cells Human Un-conjugated 5 μg Log in to see 2 to 3 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
HOST_Baculovirus Human GST-His-Tag Recombinant HCK protein tested by SDS-PAGE gel. 0.5 µg of HCK protein ... 10 μg Log in to see 1 to 2 Days
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
HOST_Sf-9 cells Human Un-conjugated   5 μg Log in to see 3 to 4 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

HCK Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
, ,
Mouse (Murine)

Rat (Rattus)

Top referenced HCK Proteins

  1. Human HCK Protein expressed in Baculovirus infected Insect Cells - ABIN411927 : Piccardoni, Manarini, Federico, Bagoly, Pecce, Martelli, Piccoli, Totani, Cerletti, Evangelista: SRC-dependent outside-in signalling is a key step in the process of autoregulation of beta2 integrins in polymorphonuclear cells. in The Biochemical journal 2004 (PubMed)
    Show all 3 references for ABIN411927

More Proteins for Hemopoietic Cell Kinase (HCK) Interaction Partners

Human Hemopoietic Cell Kinase (HCK) interaction partners

  1. we provide evidence for involvement of HCK and FGR (show FGR Proteins) in FCRL4 (show FCRL4 Proteins)-mediated immunoregulation and for the functional importance of posttranslational modifications of the FCRL4 (show FCRL4 Proteins) molecule.

  2. Interaction with the Src (show SRC Proteins) homology (SH3-SH2) region of the Hck structures the HIV-1 Nef dimer for kinase activation and effector recruitment.

  3. Interaction between Nef and Hck is important for Nef-dependent modulation of viral infectivity.

  4. Data indicate that combined treatment using SFK (LYN (show LYN Proteins), HCK, or FGR (show FGR Proteins)) and c-KIT inhibitor dasatinib dasatinib and chemotherapy provides a novel approach to increasing p53 (show TP53 Proteins) activity and enhancing targeting of acute myeloid leukemia (show BCL11A Proteins) (AML (show RUNX1 Proteins)) stem cells.

  5. The SRC (show SRC Proteins) family tyrosine kinase (show TXK Proteins) HCK and the ETS (show ETS1 Proteins) family transcription factors SPIB (show SPIB Proteins) and EHF (show EHF Proteins) regulate transcytosis across a human follicle-associated epithelium model.

  6. This particular binding mode enables Hck SH3 to sense a specific non-canonical residue situated in the SH3 RT-loop of the kinase.

  7. the activation of Hck, Lyn and c-Src by Nef is highly conserved among all major clades of HIV-1

  8. There were significant differences in the genotype and allele distribution of -627 G/T polymorphism in Hck gene between cases and controls.

  9. Hck activation at the Golgi apparatus causes the HIV-1 Nef-induced c-Fms (show CSF1R Proteins) proto-oncogene (show CSF1R Proteins) N-glycosylation defect.

  10. Loss of HCK is associated with acute promyelocytic leukemia (show PML Proteins).

Mouse (Murine) Hemopoietic Cell Kinase (HCK) interaction partners

  1. Data indicate that Src (show SRC Proteins)-Family Kinases Hck and Fgr (show FGR Proteins) regulate cytokine secretion by macrophages.

  2. Hck is not only progressively overexpressed in atherosclerosis, but it also controls critical molecular processes in monocyte influx, blood monocyte subset balance, macrophage accumulation, and the maintenance of atherosclerotic lesion stability.

  3. The Src (show SRC Proteins) family kinases Hck, Fgr (show FGR Proteins), and Lyn (show LYN Proteins) are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment.

  4. tyrosine phosphorylation of WASP (show WASL Proteins) by Hck is required for proper macrophage functions

  5. Hck is one of the very few effectors of preosteoclast recruitment described to date and thereby plays a critical role in bone remodeling.

  6. Despite possessing enhanced killing, alveolar macrophage Hck/Fgr (show FGR Proteins)/Lyn (show LYN Proteins)-deficient ("triple-knockout") mice do not demonstrate enhanced inflammatory responses to Pneumocystis murina.

  7. Taken together, PKR (show EIF2AK2 Proteins) and Hck were critical for DON-induced ribosomal recruitment of p38 (show CRK Proteins), its subsequent phosphorylation, and, ultimately, p38 (show CRK Proteins)-driven proinflammatory cytokine expression.

  8. Nef participates in HIV-1-induced multinucleated giant cells formation via a p61Hck- and lysosomal enzyme-dependent pathway

  9. spatial organization of podosomes as large rosettes, proteolytic degradation of extracellular matrix, and 3D migration appeared to be functionally linked and regulated by Hck in macrophages

  10. enhanced innate immune response in Hck(F/F) mice thereby skewing innate immunity from a reversible physiological host defense response to one causing irreversible tissue damage

Cow (Bovine) Hemopoietic Cell Kinase (HCK) interaction partners

  1. A truncated, mRNA-encoded src-related tyrosine kinase (show FRK Proteins) HCK could function as an adaptor protein or as a competitive inhibitor in spermiogenesis or mature sperm functions.

  2. the presence of mRNAs encoding for hck and hck-tr in testicular germ cells; hck-tr being translated during spermatogenesis and expressed on mature ejaculated bull spermatozoa.

HCK Protein Profile

Protein Summary

The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon.

Gene names and symbols associated with Hemopoietic Cell Kinase Proteins (HCK)

  • hemopoietic cell kinase (tklal-a)
  • hemopoietic cell kinase (HCK)
  • hemopoietic cell kinase (hck)
  • hemopoietic cell kinase (Hck)
  • AI849071 protein
  • Bmk protein
  • HCK protein
  • Hctk protein
  • JTK9 protein
  • laloo protein
  • MGC107870 protein
  • p56Hck protein
  • p59Hck protein
  • p61Hck protein

Protein level used designations for Hemopoietic Cell Kinase Proteins (HCK)

hemopoietic cell kinase , non-receptor protein tyrosine kinase laloo , tyrosine-protein kinase HCK-like , hematopoietic cell kinase , p59-HCK/p60-HCK , tyrosine-protein kinase HCK , B cell/myeloid kinase , B-cell/myeloid kinase , p56-HCK/p59-HCK , hemopoietic cell tyrosine kinase , p56-HCK

373700 Xenopus laevis
458163 Pan troglodytes
485828 Canis lupus familiaris
548439 Xenopus (Silurana) tropicalis
100455620 Pongo abelii
100587780 Nomascus leucogenys
3055 Homo sapiens
15162 Mus musculus
25734 Rattus norvegicus
419280 Gallus gallus
280814 Bos taurus
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