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Heparanase Proteins (HPSE)

Heparan sulfate proteoglycans are major components of the basement membrane and extracellular matrix. Additionally we are shipping Heparanase Antibodies (194) and Heparanase Kits (46) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HPSE 10855 Q9Y251
HPSE 15442 Q6YGZ1
HPSE 64537 Q71RP1
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Top Heparanase Proteins at antibodies-online.com

Showing 10 out of 29 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
$633.60
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$732.60
Details
HOST_Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 9 to 11 Days
$844.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,093.67
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,093.67
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$388.93
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 ng Log in to see 6 to 11 Days
$1,157.14
Details

HPSE Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

Rat (Rattus) ,

More Proteins for Heparanase (HPSE) Interaction Partners

Human Heparanase (HPSE) interaction partners

  1. higher heparanase expression in gastric cancer is associated with clinicopathologic features of depth of invasion, lymph node metastasis.

  2. JAK-2 (show JAK2 Proteins) V617F mutation results in heparanase up-regulation via the erythropoietin receptor (show EPOR Proteins).

  3. Studies indicate that heparanase (HPSE) has been a potential target of medical treatment.

  4. our results suggest that HPSE contributes to the proliferation and metastasis of Ovarian cancer and HPSE might be a potent molecular target for Ovarian cancer treatment

  5. Heparanase is over expressed in preeclamptic placentas compared to normal healthy controls, suggesting its role in the development of preeclampsia.

  6. Taken together, it is concluded that colon 26 cells transduce the heparanase-mediated signal through heparan sulfate binding.

  7. Report FGF23 (show FGF23 Proteins)/klotho (show KL Proteins)/heparanase signaling axis active in multiple myeloma.

  8. Elevated heparanase procoagulant activity in patients with lung cancer reveals a new mechanism of coagulation system activation in malignancy. Heparanase procoagulant activity can potentially be used as a predictor for survival.

  9. heparanase contributes to allergen-induced eosinophil recruitment to the lung.

  10. Our findings suggest a link between heparanase, syndecan-1 (show SDC1 Proteins), and VEGF (show VEGFA Proteins) in the progression of PDR and that heparanase is a potential target for therapy of diabetic retinopathy.

Mouse (Murine) Heparanase (HPSE) interaction partners

  1. heparanase contributes to allergen-induced eosinophil recruitment to the lung.

  2. Unfractionated heparin inhibits heparanase, and reverses the activation of NF-kappaB (show NFKB1 Proteins) and MAPK P38 (show MAPK1 Proteins) signaling pathways to attenuate inflammatory responses induced by sepsis. These results suggest that UFH

  3. Results show a critical role for heparanase in regulating the branching and invasive behavior of normal mammary epithelia which could be the result of its mutually reciprocal feedback with MMP-14 (show MMP14 Proteins).

  4. Data suggest a potential mechanism of diabetic enteropathy, which is depending remarkably on syndecan-1 (Sdc1 (show SDC1 Proteins)) and -beta-D-glucuronidase (show GUSB Proteins) heparanase (HPSE).

  5. Findings identify a dual function for HPSE in malignant melanoma with a protumorigenic extracellular activity and a tumor-suppressive nuclear action.

  6. Studies in heparanase-deficient mice established its contributions to autophagy.

  7. Heparanase is suggested to be a prognostic and diagnostic marker for oral premalignant lesions which could have a major impact on future prognosis and diagnosis of SCC (show CYP11A1 Proteins) of the oral cavity.

  8. Novel function of heparanase guides cancer-promoting action of TAM (show CCNA1 Proteins) and heparanase expression status may be predictive of treatment potential, targeting TAM (show CCNA1 Proteins)/IL-6 (show IL6 Proteins)/STAT3 (show STAT3 Proteins).

  9. Under diabetic conditions, latent heparanase, overexpressed by glomerular cells and posttranslationally activated by cathepsin L (show CTSL1 Proteins) of tubular origin creates chronic inflammatory conditions and fosters macrophage-mediated renal injury.

  10. We found that heparanase induction is associated with decreased levels of CXCL10 (show CXCL10 Proteins), suggesting that this chemokine (show CCL1 Proteins) exerts tumor-suppressor properties in myeloma.

Pig (Porcine) Heparanase (HPSE) interaction partners

  1. during late gestation, the mRNA and HPSE levels were higher in Meishan placentae than Yorkshire pigs

  2. study of tissue expression profiles, polymorphisms of HPSE and HPSE2 genes and changes of their mRNA levels in porcine alveolar macrophages (PAMs) induced by PRRSV; upon stimulation in healthy piglets with PRRSV, HPSE mRNA was obviously upregulated, while HPSE2 mRNA did not induce a prominent change in PAMs

  3. our results support a critical role for heparanase in the development of vulnerable atherosclerotic plaques

  4. report molecular cloning and characterisation of heparanase mRNA in the porcine placenta throughout gestation.

Cow (Bovine) Heparanase (HPSE) interaction partners

  1. Suggest that high glucose is a potent stimulator of endothelial heparanase secretion.

  2. Lutropin (show LHB Proteins) induces a transient increase in HPSE mRNA at specific times after its addition.

Heparanase (HPSE) Protein Profile

Protein Summary

Heparan sulfate proteoglycans are major components of the basement membrane and extracellular matrix. The protein encoded by this gene is an enzyme that cleaves heparan sulfate proteoglycans to permit cell movement through remodeling of the extracellular matrix. In addition, this cleavage can release bioactive molecules from the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Heparanase Proteins (HPSE)

  • heparanase (HPSE)
  • heparanase (hpse)
  • heparanase (Hpse)
  • heparanase (LOC100101601)
  • Hep protein
  • Hpa protein
  • HPA1 protein
  • Hpr1 protein
  • HPSE protein
  • HPSE1 protein
  • HSE1 protein
  • im:7144134 protein

Protein level used designations for Heparanase Proteins (HPSE)

heparanase , endo-glucoronidase , heparanase-1 , endoglycosidase heparanase , heparanase-like

GENE ID SPECIES
100061267 Equus caballus
563020 Danio rerio
100145320 Xenopus (Silurana) tropicalis
461206 Pan troglodytes
707583 Macaca mulatta
10855 Homo sapiens
15442 Mus musculus
64537 Rattus norvegicus
100101601 Oryctolagus cuniculus
100721886 Cavia porcellus
608707 Canis lupus familiaris
100271932 Sus scrofa
281230 Bos taurus
373981 Gallus gallus
101118612 Ovis aries
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