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Heparanase Proteins (HPSE)

Heparan sulfate proteoglycans are major components of the basement membrane and extracellular matrix. Additionally we are shipping Heparanase Antibodies (195) and Heparanase Kits (36) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HPSE 10855 Q9Y251
HPSE 15442 Q6YGZ1
HPSE 64537 Q71RP1
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Top Heparanase Proteins at antibodies-online.com

Showing 10 out of 29 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
$633.60
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$732.60
Details
HOST_Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 9 to 11 Days
$844.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,093.67
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,093.67
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$388.93
Details
HOST_Synthetic Human Ovalbumin   100 μg Log in to see 11 to 13 Days
$616.00
Details

HPSE Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

Rat (Rattus) ,

More Proteins for Heparanase (HPSE) Interaction Partners

Human Heparanase (HPSE) interaction partners

  1. Heparanase up-regulated the expression of the blood coagulation initiator-tissue factor (show F3 Proteins) (TF) and interacted with the tissue factor pathway inhibitor (TFPI (show TFPI Proteins)) on the cell surface membrane of endothelial and tumor cells, leading to dissociation of TFPI (show TFPI Proteins) and resulting in increased cell surface coagulation activity. [review]

  2. Heparanase procoagulant activity predicts post-surgery necrosis.

  3. Suggest heparanase is a promising, novel target for overcoming myeloma resistance to therapy and that targeting heparanase has the potential to prevent relapse in myeloma and possibly other cancers.

  4. expression of BRMS1 (show BRMS1 Proteins) and/or HPA might be closely related to the carcinogenesis, clinical biological behaviors, and prognosis of gallbladder adenocarcinoma

  5. in colorectal adenomas, the heparanase-1 does not participate in syndecan-1 (show SDC1 Proteins) degradation; the heparanase-2 does not stimulate syndecan-1 (show SDC1 Proteins) degradation by the action of heparanase-1, and the heparanase-2 may be involved in the modulation of the heparanase-1 activity.

  6. higher heparanase expression in gastric cancer is associated with clinicopathologic features of depth of invasion, lymph node metastasis.

  7. JAK-2 (show JAK2 Proteins) V617F mutation results in heparanase up-regulation via the erythropoietin receptor (show EPOR Proteins).

  8. Studies indicate that heparanase (HPSE) has been a potential target of medical treatment.

  9. our results suggest that HPSE contributes to the proliferation and metastasis of Ovarian cancer and HPSE might be a potent molecular target for Ovarian cancer treatment

  10. Heparanase is over expressed in preeclamptic placentas compared to normal healthy controls, suggesting its role in the development of preeclampsia.

Mouse (Murine) Heparanase (HPSE) interaction partners

  1. heparanase contributes to allergen-induced eosinophil recruitment to the lung.

  2. Unfractionated heparin inhibits heparanase, and reverses the activation of NF-kappaB (show NFKB1 Proteins) and MAPK P38 (show MAPK1 Proteins) signaling pathways to attenuate inflammatory responses induced by sepsis. These results suggest that UFH

  3. Results show a critical role for heparanase in regulating the branching and invasive behavior of normal mammary epithelia which could be the result of its mutually reciprocal feedback with MMP-14 (show MMP14 Proteins).

  4. Data suggest a potential mechanism of diabetic enteropathy, which is depending remarkably on syndecan-1 (Sdc1 (show SDC1 Proteins)) and -beta-D-glucuronidase (show GUSB Proteins) heparanase (HPSE).

  5. Findings identify a dual function for HPSE in malignant melanoma with a protumorigenic extracellular activity and a tumor-suppressive nuclear action.

  6. Studies in heparanase-deficient mice established its contributions to autophagy.

  7. Heparanase is suggested to be a prognostic and diagnostic marker for oral premalignant lesions which could have a major impact on future prognosis and diagnosis of SCC (show CYP11A1 Proteins) of the oral cavity.

  8. Novel function of heparanase guides cancer-promoting action of TAM (show CCNA1 Proteins) and heparanase expression status may be predictive of treatment potential, targeting TAM (show CCNA1 Proteins)/IL-6 (show IL6 Proteins)/STAT3 (show STAT3 Proteins).

  9. Under diabetic conditions, latent heparanase, overexpressed by glomerular cells and posttranslationally activated by cathepsin L (show CTSL1 Proteins) of tubular origin creates chronic inflammatory conditions and fosters macrophage-mediated renal injury.

  10. We found that heparanase induction is associated with decreased levels of CXCL10 (show CXCL10 Proteins), suggesting that this chemokine (show CCL1 Proteins) exerts tumor-suppressor properties in myeloma.

Pig (Porcine) Heparanase (HPSE) interaction partners

  1. during late gestation, the mRNA and HPSE levels were higher in Meishan placentae than Yorkshire pigs

  2. study of tissue expression profiles, polymorphisms of HPSE and HPSE2 genes and changes of their mRNA levels in porcine alveolar macrophages (PAMs) induced by PRRSV; upon stimulation in healthy piglets with PRRSV, HPSE mRNA was obviously upregulated, while HPSE2 mRNA did not induce a prominent change in PAMs

  3. our results support a critical role for heparanase in the development of vulnerable atherosclerotic plaques

  4. report molecular cloning and characterisation of heparanase mRNA in the porcine placenta throughout gestation.

Cow (Bovine) Heparanase (HPSE) interaction partners

  1. Suggest that high glucose is a potent stimulator of endothelial heparanase secretion.

  2. Lutropin (show LHB Proteins) induces a transient increase in HPSE mRNA at specific times after its addition.

Heparanase (HPSE) Protein Profile

Protein Summary

Heparan sulfate proteoglycans are major components of the basement membrane and extracellular matrix. The protein encoded by this gene is an enzyme that cleaves heparan sulfate proteoglycans to permit cell movement through remodeling of the extracellular matrix. In addition, this cleavage can release bioactive molecules from the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Heparanase Proteins (HPSE)

  • heparanase (HPSE)
  • heparanase (hpse)
  • heparanase (Hpse)
  • heparanase (LOC100101601)
  • Hep protein
  • Hpa protein
  • HPA1 protein
  • Hpr1 protein
  • HPSE protein
  • HPSE1 protein
  • HSE1 protein
  • im:7144134 protein

Protein level used designations for Heparanase Proteins (HPSE)

heparanase , endo-glucoronidase , heparanase-1 , endoglycosidase heparanase , heparanase-like

GENE ID SPECIES
100061267 Equus caballus
563020 Danio rerio
100145320 Xenopus (Silurana) tropicalis
461206 Pan troglodytes
707583 Macaca mulatta
10855 Homo sapiens
15442 Mus musculus
64537 Rattus norvegicus
100101601 Oryctolagus cuniculus
100721886 Cavia porcellus
608707 Canis lupus familiaris
100271932 Sus scrofa
281230 Bos taurus
373981 Gallus gallus
101118612 Ovis aries
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