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HNRNPA2B1 belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). Additionally we are shipping HNRNPA2B1 Antibodies (122) and HNRNPA2B1 Kits (41) and many more products for this protein.
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Data suggest that galectin-3 (show LGALS3 Proteins) and heterogeneous ribonucleoprotein particle component hnRNPA2B1 interact as members of the early splicing machinery.
effect of mutations on the aggregation propensity of hnRNPA2
ALS-associated hnRNPA2B1 D290V mutant patient fibroblasts and motor neurons differentiated from iPSCs (iPSC-MNs) demonstra (show IGFALS Proteins)te abnormal splicing changes, likely d (show DAO Proteins)ue to increased nuclear-insoluble hnRNPA2B1. Mutant iPSC-MNs display decreased survival in long-term culture and exhibit hnRNPA2B1 localization to cytoplasmic granules as well as exacerbated changes in gene expression and splicing upon cellular stress.
Motor-neuron disease (MND)-linked RNA-binding proteins (RBPs), TDP-43 (show TARDBP Proteins), FUS (show FUS Proteins), and hnRNPA2B1, bind to and induce structural alteration of UGGAAexp. These RBPs suppress UGGAAexp-mediated toxicity in Drosophila by functioning as RNA chaperones for proper UGGAAexp folding and regulation of pentapeptide repeat translation.
To examine the relationship between amino acid sequence and aggregation propensity, a diverse set of point mutations in the hnRNPA2B1 prion (show PRNP Proteins)-like domain.
We concluded that hnRNPA2B1 promotes the tumorigenic potential of breast cancer cells, MCF-7 and MDA-MB-231, through the extracellular-signal-regulated kinase 1/2 (show MAPK3 Proteins) or signal transducer and activator of transcription 3 (show STAT3 Proteins) pathway, which may serve as a target for future therapies.
results demonstrate that hnRNPA2/B1 promotes tumor cell growth by activating COX-2 signaling in NSCLC cells and imply that the hnRNPA2/B1/COX-2 pathway may be a potential therapeutic target for human lung cancers.
Detection of hnRNP A2/B1 expression may be useful as a biomarker for prediction of glioma progression.
The results indicate both genetic and physical interactions between disease-linked RNA-binding proteinss and DNAJB6/mrj (show DNAJB6 Proteins), suggesting etiologic overlap between the pathogenesis of adult-onset inherited myopathies initiated by mutations in hnRNPA2B1 and DNAJB6 (show DNAJB6 Proteins).
hnRNPA2B1, hnRNPD (show HNRNPD Proteins), hnRNPL (show HNRNPL Proteins) , and YBX1 (show YBX1 Proteins) might play important roles in gastric cancer tumorigenesis.
HnRNP A2/B1 loss results in alternative splicing (AS), including skipping of an exon in amyotrophic lateral sclerosis (ALS)-associated D-amino acid oxidase (DAO (show DAO Proteins)) that reduces D-serine metabolism.
Findings suggest that hnRNP A2/B1 has an important role in regulation of the innate immune system, especially at the level of monocyte/macrophage activation.
hnRNPA2/B1 plays a functional role in SMC differentiation from stem cells in vitro and embryonic branchial arch artery development.
splicing repressors hnRNP A1 and A2, as well as the polypyrimidine-tract-binding protein PTB, contribute to control of pyruvate kinase isoform M1 and M2 expression
overproduction of TNF-alpha leads to aberrant expression of hnRNP-A2 in the rheumatoid joint and subsequently to autoimmune reactions, which may enhance the inflammatory and destructive process.
These results are consistent with a model where hnRNP E1 recruited to A2RE RNA granules by binding to hnRNP A2 inhibits translation of A2RE RNA during granule transport.
Active Fyn (show FYN Proteins) phosphorylates hnRNP (show HNRNPH2 Proteins) A2 and stimulates translation of an myelin basic protein (MBP (show MBP Proteins)) A2RE (A2 response element) -containing reporter construct.
A common mechanism of mitochondrial respiratory stress-induced activation of nuclear target genes that involves hnRNP A2 as a transcription coactivator, is described.
This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. This gene has been described to generate two alternatively spliced transcript variants which encode different isoforms.
heterogeneous nuclear ribonucleoprotein A2/B1
, Heterogeneous nuclear ribonucleoprotein A2 homolog 1
, heterogeneous nuclear ribonucleoproteins A2/B1
, hnRNP A2 / hnRNP B1
, nuclear ribonucleoprotein particle A2 protein
, hnRNP A2/B1
, heterogenous nuclear ribonucleoprotein A2/B1
, heterogeneous nuclear ribonucleoprotein A2
, heterogeneous nuclear ribonucleoprotein B0a
, heterogeneous nuclear ribonucleoprotein B0b
, heterogeneous nuclear ribonucleoprotein B1