Heterogeneous Nuclear Ribonucleoprotein A2/B1 Proteins (HNRNPA2B1)

HNRNPA2B1 belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). Additionally we are shipping HNRNPA2B1 Antibodies (122) and HNRNPA2B1 Kits (41) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HNRNPA2B1 100359650  
HNRNPA2B1 3181 P22626
HNRNPA2B1 53379 O88569
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Top HNRNPA2B1 Proteins at antibodies-online.com

Showing 9 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
Yeast Saguinus oedipus His tag   1 mg Log in to see 60 to 71 Days
$2,924.17
Details
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$2,924.17
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$2,960.83
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 15 to 18 Days
$768.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 11 to 18 Days
$976.25
Details

HNRNPA2B1 Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Human , ,
, ,
Mouse (Murine)

More Proteins for Heterogeneous Nuclear Ribonucleoprotein A2/B1 (HNRNPA2B1) Interaction Partners

Human Heterogeneous Nuclear Ribonucleoprotein A2/B1 (HNRNPA2B1) interaction partners

  1. Data suggest that galectin-3 (show LGALS3 Proteins) and heterogeneous ribonucleoprotein particle component hnRNPA2B1 interact as members of the early splicing machinery.

  2. effect of mutations on the aggregation propensity of hnRNPA2

  3. ALS-associated hnRNPA2B1 D290V mutant patient fibroblasts and motor neurons differentiated from iPSCs (iPSC-MNs) demonstra (show IGFALS Proteins)te abnormal splicing changes, likely d (show DAO Proteins)ue to increased nuclear-insoluble hnRNPA2B1. Mutant iPSC-MNs display decreased survival in long-term culture and exhibit hnRNPA2B1 localization to cytoplasmic granules as well as exacerbated changes in gene expression and splicing upon cellular stress.

  4. Motor-neuron disease (MND)-linked RNA-binding proteins (RBPs), TDP-43 (show TARDBP Proteins), FUS (show FUS Proteins), and hnRNPA2B1, bind to and induce structural alteration of UGGAAexp. These RBPs suppress UGGAAexp-mediated toxicity in Drosophila by functioning as RNA chaperones for proper UGGAAexp folding and regulation of pentapeptide repeat translation.

  5. To examine the relationship between amino acid sequence and aggregation propensity, a diverse set of point mutations in the hnRNPA2B1 prion (show PRNP Proteins)-like domain.

  6. We concluded that hnRNPA2B1 promotes the tumorigenic potential of breast cancer cells, MCF-7 and MDA-MB-231, through the extracellular-signal-regulated kinase 1/2 (show MAPK3 Proteins) or signal transducer and activator of transcription 3 (show STAT3 Proteins) pathway, which may serve as a target for future therapies.

  7. results demonstrate that hnRNPA2/B1 promotes tumor cell growth by activating COX-2 signaling in NSCLC cells and imply that the hnRNPA2/B1/COX-2 pathway may be a potential therapeutic target for human lung cancers.

  8. Detection of hnRNP A2/B1 expression may be useful as a biomarker for prediction of glioma progression.

  9. The results indicate both genetic and physical interactions between disease-linked RNA-binding proteinss and DNAJB6/mrj (show DNAJB6 Proteins), suggesting etiologic overlap between the pathogenesis of adult-onset inherited myopathies initiated by mutations in hnRNPA2B1 and DNAJB6 (show DNAJB6 Proteins).

  10. hnRNPA2B1, hnRNPD (show HNRNPD Proteins), hnRNPL (show HNRNPL Proteins) , and YBX1 (show YBX1 Proteins) might play important roles in gastric cancer tumorigenesis.

Mouse (Murine) Heterogeneous Nuclear Ribonucleoprotein A2/B1 (HNRNPA2B1) interaction partners

  1. HnRNP A2/B1 loss results in alternative splicing (AS), including skipping of an exon in amyotrophic lateral sclerosis (ALS)-associated D-amino acid oxidase (DAO (show DAO Proteins)) that reduces D-serine metabolism.

  2. Findings suggest that hnRNP A2/B1 has an important role in regulation of the innate immune system, especially at the level of monocyte/macrophage activation.

  3. hnRNPA2/B1 plays a functional role in SMC differentiation from stem cells in vitro and embryonic branchial arch artery development.

  4. splicing repressors hnRNP A1 and A2, as well as the polypyrimidine-tract-binding protein PTB, contribute to control of pyruvate kinase isoform M1 and M2 expression

  5. overproduction of TNF-alpha leads to aberrant expression of hnRNP-A2 in the rheumatoid joint and subsequently to autoimmune reactions, which may enhance the inflammatory and destructive process.

  6. These results are consistent with a model where hnRNP E1 recruited to A2RE RNA granules by binding to hnRNP A2 inhibits translation of A2RE RNA during granule transport.

  7. Active Fyn (show FYN Proteins) phosphorylates hnRNP (show HNRNPH2 Proteins) A2 and stimulates translation of an myelin basic protein (MBP (show MBP Proteins)) A2RE (A2 response element) -containing reporter construct.

  8. A common mechanism of mitochondrial respiratory stress-induced activation of nuclear target genes that involves hnRNP A2 as a transcription coactivator, is described.

HNRNPA2B1 Protein Profile

Protein Summary

This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. This gene has been described to generate two alternatively spliced transcript variants which encode different isoforms.

Gene names and symbols associated with HNRNPA2B1

  • heterogeneous nuclear ribonucleoprotein A2/B1 (hnrpa2b1)
  • heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1)
  • heterogeneous nuclear ribonucleoprotein A2/B1 (hnrnpa2b1)
  • heterogeneous nuclear ribonucleoprotein A2/B1 (LOC100359650)
  • heterogeneous nuclear ribonucleoprotein A2/B1 (LOC100359712)
  • heterogeneous nuclear ribonucleoprotein A2/B1 (Hnrnpa2b1)
  • heterogeneous nuclear ribonucleoprotein A2/B1-like (LOC100353281)
  • 9130414A06Rik protein
  • hnRNP protein
  • hnrnp-A protein
  • HNRNPA2 protein
  • HNRNPA2B1 protein
  • HNRNPB1 protein
  • Hnrpa2 protein
  • Hnrpa2b1 protein
  • HNRPB1 protein
  • MGC53135 protein
  • RNPA2 protein
  • SNRPB1 protein

Protein level used designations for HNRNPA2B1

heterogeneous nuclear ribonucleoprotein A2/B1 , Heterogeneous nuclear ribonucleoprotein A2 homolog 1 , heterogeneous nuclear ribonucleoproteins A2/B1 , hnRNP A2 / hnRNP B1 , nuclear ribonucleoprotein particle A2 protein , hnRNP A2/B1 , heterogenous nuclear ribonucleoprotein A2/B1 , heterogeneous nuclear ribonucleoprotein A2 , heterogeneous nuclear ribonucleoprotein B0a , heterogeneous nuclear ribonucleoprotein B0b , heterogeneous nuclear ribonucleoprotein B1

GENE ID SPECIES
380082 Xenopus laevis
463299 Pan troglodytes
549680 Xenopus (Silurana) tropicalis
701821 Macaca mulatta
100359650 Rattus norvegicus
100359712 Rattus norvegicus
100561250 Anolis carolinensis
100583405 Nomascus leucogenys
3181 Homo sapiens
507564 Bos taurus
53379 Mus musculus
362361 Rattus norvegicus
475260 Canis lupus familiaris
100521762 Sus scrofa
420627 Gallus gallus
100715127 Cavia porcellus
101107187 Ovis aries
100353281 Oryctolagus cuniculus
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