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HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. Additionally we are shipping Heterogeneous Nuclear Ribonucleoprotein L-Like Kits (13) and Heterogeneous Nuclear Ribonucleoprotein L-Like Proteins (2) and many more products for this protein.
Showing 10 out of 46 products:
Cow (Bovine) Polyclonal HNRPLL Primary Antibody for IHC, WB - ABIN2776622
Shur, Ben-Avraham, Benayahu: Alternatively spliced isoforms of a novel stromal RNA regulating factor. in Gene 2004
Show all 5 references for 2776622
Cow (Bovine) Polyclonal HNRPLL Primary Antibody for WB - ABIN2776623
Lim, Hao, Shaw, Patel, Szabó, Rual, Fisk, Li, Smolyar, Hill, Barabási, Vidal, Zoghbi: A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. in Cell 2006
Loss-of-function mutati (show PTPRC Antibodies)on of hnRNPLL disrupts peripheral T cell accumulation even in the absence of CD45 protein, indicating that hnRNPLL acts through an independent mechanism to promote (show PTPRC Antibodies)peripheral T cell longevity.
Participation of SRRF (Stromal RNA Regulating Factor) isoforms in post-transcriptional events in bone marrow stromal cells; an important role in regulation of the RNA expression that directs the bone marrow stromal cells differentiation pathway
identification of heterogeneous ribonucleoprotein L-like (hnRNPLL) as a critical inducible regulator of CD45 (show PTPRC Antibodies) alternative splicing
These data establish that hnRNP (show HNRNPC Antibodies) LL plays a critical and unique role in the signal-induced regulation of CD45 (show PTPRC Antibodies) and demonstrate the utility of cell-based screens for the identification of novel splicing regulatory factors.
Data suggest that hnRNPLL specifically associates with cytoplasmic PABPC1 (show PABPC1 Antibodies) in both T-lymphocytes and plasma cells; PABPC1 (show PABPC1 Antibodies) promotes binding of hnRNPLL to immunoglobulin H (IgH, heavy chain) mRNA and regulates switching from mIgH (membrane isoform) to sIgH (secreted isoform) in plasma cells. (hnRNPLL = heterogeneous nuclear ribonucleoprotein L-like protein; PABPC1 (show PABPC1 Antibodies) = cytoplasmic poly[A]-binding protein 1)
We identify similar patterns of hnRNPLL-induced differential intron retention flanking alternative exons in 14 other genes, representing novel elements of the hnRNPLL-induced splicing program in T cells.
Data indicate that the RNA-binding protein hnRNPLL has a critical role in tuning transcriptomes of terminally differentiating B lymphocytes.
The splicing factor hnRNPLL and the transcription elongation factor ELL2 modulate the ratio of secred versus membrane-encoding Ighg2b transcripts at the expense of the secreted isoform.
results highlight both overlapping and divergent roles for hnRNPLL between conventional T cells and NKT (show CTSL1 Antibodies) cells
In T cells with no CD45 (show PTPRC Antibodies) protein, hnRNPLL mutation diminishes peripheral T cell accumulation and demonstrates that hnRNPLL regulates T cell longevity independently from its effects on CD45 (show PTPRC Antibodies) splicing.
A single substitution in a memory-induced RNA-binding protein, hnRNPLL, destabilized an RNA-recognition domain that bound with micromolar affinity to RNA containing the Ptprc (show PTPRC Antibodies) exon-silencing sequence.
HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC\; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation (Oberdoerffer et al., 2008
heterogeneous nuclear ribonucleoprotein L-like
, Heterogeneous nuclear ribonucleoprotein L-like
, stromal RNA regulating factor
, stromal RNA-regulating factor