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Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Additionally we are shipping Hexokinase 1 Proteins (39) and Hexokinase 1 Kits (38) and many more products for this protein.
Showing 10 out of 224 products:
Human Polyclonal Hexokinase 1 Primary Antibody for EIA, IHC (p) - ABIN360644
van Wijk, Rijksen, Huizinga, Nieuwenhuis, van Solinge: HK Utrecht: missense mutation in the active site of human hexokinase associated with hexokinase deficiency and severe nonspherocytic hemolytic anemia. in Blood 2002
Show all 5 references for ABIN360644
Human Polyclonal Hexokinase 1 Primary Antibody for EIA, IHC (p) - ABIN360645
Cannizzo, Kral: Obesity surgery: a model of programmed undernutrition. in Current opinion in clinical nutrition and metabolic care 1999
Show all 5 references for ABIN360645
Human Monoclonal Hexokinase 1 Primary Antibody for ICC, IHC - ABIN969194
Tsai: Function of interdomain alpha-helix in human brain hexokinase: covalent linkage and catalytic regulation between N- and C-terminal halves. in Journal of biomedical science 2007
Show all 3 references for ABIN969194
Human Monoclonal Hexokinase 1 Primary Antibody for ICC, FACS - ABIN969195
Grupe, Li, Rowland, Nowotny, Hinrichs, Smemo, Kauwe, Maxwell, Cherny, Doil, Tacey, van Luchene, Myers, Wavrant-De Vrièze, Kaleem, Hollingworth, Jehu, Foy, Archer, Hamilton, Holmans, Morris, Catanese et al.: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. ... in American journal of human genetics 2005
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Human Polyclonal Hexokinase 1 Primary Antibody for WB - ABIN611559
Fallon, Moreau, Croft, Labib, Gu, Fon: Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain. in The Journal of biological chemistry 2002
Human Polyclonal Hexokinase 1 Primary Antibody for ELISA, WB - ABIN1533647
Deloukas, Earthrowl, Grafham, Rubenfield, French, Steward, Sims, Jones, Searle, Scott, Howe, Hunt, Andrews, Gilbert, Swarbreck, Ashurst, Taylor, Battles, Bird, Ainscough, Almeida, Ashwell, Ambrose et al.: The DNA sequence and comparative analysis of human chromosome 10. ... in Nature 2004
Human Polyclonal Hexokinase 1 Primary Antibody for IHC (p), WB - ABIN392759
Lynn, Wang, Markesbery, Lovell: Quantitative changes in the mitochondrial proteome from subjects with mild cognitive impairment, early stage, and late stage Alzheimer's disease. in Journal of Alzheimer's disease : JAD 2010
Human Monoclonal Hexokinase 1 Primary Antibody for EIA, IHC (p) - ABIN317095
Wilson: Isozymes of mammalian hexokinase: structure, subcellular localization and metabolic function. in The Journal of experimental biology 2003
4-hydroxytamoxifen resistance in breast cancer cells is suppressed by curcumin, which targets the SLUG (show SNAI2 Antibodies)/Hexokinase 2 (show HK2 Antibodies) pathway
Our results suggest that overexpression of PKM2 and HK1 (show KCNA4 Antibodies), especially the latter, significantly associates with lymphatic metastasis, advanced clinical staging and unfavorable prognosis in gastric cancer.
HK1 (show KCNA4 Antibodies) and HK2 (show HK2 Antibodies) expression alterations were detected, that could be explained by common deregulation mechanisms of these genes in colorectal tumors. The HK3 (show HK3 Antibodies) expression level was significantly increased in 60% of samples.
Data indicate a missense mutation in hexokinase 1 (HK1) c.2539G > A, p.Glu847Lys, tracking with disease in all affected family members.
HK1 expression is highly enriched in neurons compared to astrocytes in the cerebral cortex.
HK-1 (show KCNA4 Antibodies) plays a non-metabolic role in HIV-1 infected macrophages by binding to mitochondria thereby maintaining mitochondrial integrity.
The present study was designed to evaluate the involvement of hexokinase and CPT-1 (show CPT1A Antibodies) in the cell growth and proliferation of human prostate cancer cell lines, PC3 (show PCSK1 Antibodies), and LNCaP-FGC-10.
HK1 (show KCNA4 Antibodies) is expressed in retina, with two abundant isoforms expressed at similar levels. The Glu847Lys mutation is located at a highly conserved position in the protein, outside the catalytic domains.
Here, we identified HK1 (show KCNA4 Antibodies) as a novel causative gene for adRP (show PLIN2 Antibodies). This is the first report that associates the glucose metabolic pathway with human retinal degenerative disease, suggesting a potential new disease mechanism.
Hexokinase 1 (HK1) is a mitochondrial protein (show COX6B2 Antibodies) that controls the tramsmembrane potential and blocks apoptotic signals at the mitochondria.
Hexokinase expression is highly enriched in neurons compared to astrocytes.
The interaction of DREAM with hexokinase I may be important in the regulation of neuronal apoptosis.
Standard chow affects body weight, heart weight and HK activity and HKI (show TAC4 Antibodies) expression in the heart, without altering HKII (show HK2 Antibodies) expression.
HK1S is tethered in the principal piece region by PFKMS, which in turn is bound tightly to GSTM5 (show GSTM5 Antibodies) in the fibrous sheath of sperm.
HK-1 alone was sufficient to induce the activation of MAPKs and the expression of Blimp-1 (show PRDM1 Antibodies) and Xbp-1 (show XBP1 Antibodies) in B cells.
The comprehensive sequencing analysis and fine mapping approximately 26 kb of fully characterised sequence spanning the upstream exons of Hexokinase 1 (HK1), is reported.
A new spontaneous mutation in the A/J inbred mouse strain, downeast anemia (dea), causes severe hemolytic anemia with extensive tissue iron deposition and marked reticulocytosis
the Hexokinase-mitochondria interaction mediated by Akt (show AKT1 Antibodies) has a role in inhibiting apoptosis but does not require Bax (show BAX Antibodies) and Bak (show BAK1 Antibodies)
RanBP2 (show RANBP2 Antibodies) associates in vitro and in vivo and colocalizes with the mitochondrial metallochaperone, Cox11 (show COX11 Antibodies), and the pacemaker of glycolysis, hexokinase type I (HKI) via its leucine-rich domain.
Between these two strategies to activate glycogen (show GYS1 Antibodies) deposition in the absence of GK, embryonic livers choose to express massive levels of HKI (show TAC4 Antibodies) and HKII (show HK2 Antibodies).
role in cell death mediated by myo (show SYNPO2 Antibodies)-inositol accumulation
The structure of HXK1 was determined both in its inactive unliganded form and in its active glucose-bound form at resolutions of 1.8 and 2.0 A, respectively.
The CO2 metabolism of the gin2-1 mutation in A. thaliana is reported.
HXK1 mediated stimulation of NRT2.1 expression.
Data suggest that regulation of NIA1 and NIA2 nitrate reductases (NR) activity by sugars does not involve HXK1 as a glucose sensor.
Overexpression of AtHXK1 inhibits growth and accelerates leaf senescence under normal growth conditions.
HKL1 (show ZNF354A Antibodies) and HXK1 can interact, these two proteins likely form a critical node in Glc signaling that mediates overlapping, but also distinct, cellular responses to Glc and ethylene treatments.
HXK1-dependent glucose signaling uncoupled from other plant stress and defense hormone signaling has a central regulatory role in early seedling establishment.
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus\; the remainder of the protein is identical among all the isoforms. A sixth transcript variant has been described, but due to the presence of several stop codons, it is not thought to encode a protein.
, hexokinase type I
, hexokinase 1
, brain form hexokinase
, glycolytic enzyme
, downeast anemia
, hexokinase, tumor isozyme
, hexokinase I