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High Mobility Group Nucleosome Binding Domain 5 Proteins (HMGN5)

HMGN5 encodes a nuclear protein with similarities to the high mobility group proteins, HMG14 and HMG17, which suggests that this protein may function as a nucleosomal binding and transcriptional activating protein. Additionally we are shipping HMGN5 Antibodies (33) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HMGN5 79366 P82970
HMGN5 681284 B4F777
HMGN5 50887 Q9JL35
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Top HMGN5 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,197.33
Details

HMGN5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Rat (Rattus)

Mouse (Murine)

More Proteins for High Mobility Group Nucleosome Binding Domain 5 (HMGN5) Interaction Partners

Human High Mobility Group Nucleosome Binding Domain 5 (HMGN5) interaction partners

  1. NSBP1 was highly expressed in NSCLC cells. NSBP1 siRNA knockdown suppressed NSCLC cell proliferation and invasion. miR326 has a putative binding site in the NSBP1 3'UTR. NSBP1 overexpression abolished miR326 inhibition of cyclin B1 (show CCNB1 Proteins) and MMP9 (show MMP9 Proteins) expression.

  2. HMGN5 overexpression is correlated with advanced pathological grade and poorer prognosis in meningiomas

  3. Decreased miR (show MLXIP Proteins)-340 expression may contribute to the development and progression of prostate cancer through a mechanism that involves HMGN5.

  4. Our data first time identified miR (show MLXIP Proteins)-186 as the upstream regulator of NSBP1

  5. High HMGN5 expression is associated with urothelial bladder cancer.

  6. HMGN5 is an oncogene (show RAB1A Proteins) and plays an important role in prostate cancer tumorigenesis and progression. the level of HMGN5 may be used as a biomarker to predict the patients that would benefit from gemcitabine treatment.

  7. HMGN5 plays an oncogenic role in human breast cancer by inhibiting cell proliferation and invasion, and activating apoptosis, which could be exploited as a target for therapy in human breast cancer.

  8. HMGN5 knockdown sensitizes prostate cancer cells to ionizing radiation

  9. HMGN5 plays oncogenic role in osteosarcoma by promoting cell proliferation and invasion, and could be exploited as a target for therapy in osteosarcoma.

  10. HMGN5 is a critical factor in the development of chemoresistance through regulating autophagy, and it offers a novel target for improving osteosarcoma therapy.

Mouse (Murine) High Mobility Group Nucleosome Binding Domain 5 (HMGN5) interaction partners

  1. Mice overexpressing HMGN5, either globally or only in the heart, are normal at birth but develop hypertrophic heart with large cardiomyoctyes, deformed nuclei and disrupted lamina, and die of cardiac malfunction.

  2. HMGN5 overexpression induces neurite outgrowth.

  3. functional loss of HMGN5 leads to changes in transcription of Gpx6 (show GPX7 Proteins) and Hk1 (show HK1 Proteins) that alter glutathione metabolism.

  4. Phenotypic analysis of Hmgn1 (show HMGN1 Proteins)(tm1/tm1 (show TPM2 Proteins)), Hmgn3 (show HMGN3 Proteins)(tm1/tm1 (show TPM2 Proteins)), and Hmgn5(tm1/tm1 (show TPM2 Proteins)) mice and their wild type littermates with a battery of standardized tests uncovered variant-specific abnormalities.

  5. Downregulation of NSBP1 reduced the cancer growth rate, whereas tumourigenicity was not influenced.

  6. NSBP1 is an architectural protein that binds preferentially to euchromatin and modulates the fidelity of the cellular transcription profile by counteracting the chromatin-condensing activity of linker histones.

HMGN5 Protein Profile

Protein Summary

This gene encodes a nuclear protein with similarities to the high mobility group proteins, HMG14 and HMG17, which suggests that this protein may function as a nucleosomal binding and transcriptional activating protein.

Gene names and symbols associated with HMGN5

  • high mobility group nucleosome binding domain 5 (HMGN5)
  • high mobility group nucleosome binding domain 5B (Hmgn5b)
  • high-mobility group nucleosome binding domain 5 (Hmgn5)
  • GARP45 protein
  • Hmgn5 protein
  • Hmgn5l1 protein
  • NBP-45 protein
  • Nsbp1 protein

Protein level used designations for HMGN5

high mobility group nucleosome-binding domain-containing protein 5 , high-mobility group nucleosome binding domain 5 , nucleosomal binding protein 1 , nucleosome-binding protein 1 , high-mobility group nucleosome binding domain 5-like 1 , nucleosome binding protein 1 , nucleosome binding protein 45

GENE ID SPECIES
79366 Homo sapiens
681284 Rattus norvegicus
50887 Mus musculus
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