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Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Additionally we are shipping Histamine Receptor H4 Kits (23) and Histamine Receptor H4 Proteins (5) and many more products for this protein.
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Pharmacological or genetic modulations of H2 and H4 HRs (H2R (show HRH2 Antibodies) and H4R) not only suppressed gefitinib-induced cytostasis and differentiation of AML (show RUNX1 Antibodies) cells but also blocked EGFR (show EGFR Antibodies) and ERK1/2 (show MAPK1/3 Antibodies) inhibition in MDA-MB-231 cells
Histamine H4 receptors could not be identified in five experimental models of the guinea-pig that are suited for the detection of presynaptic inhibitory receptors (hippocampus aorta, atrium, renal cortex and vas (show AVP Antibodies) deferens) whereas H3 receptors could be shown in the peripheral tissues but not in the hippocampus
Taken together these data demonstrate that compound A and compound L may block H4R-mediated downstream signaling events.
We also found that the activation of H4R caused the release of IL-13 (show IL13 Antibodies) and RANTES (show CCL5 Antibodies) on human mast cells.these data demonstrate that the H4R activates divergent signaling pathways to induce cytokine and chemokine (show CCL1 Antibodies) production in human mast cells
H4R may be involved in the maintenance of healthy oral mucosa. In oral lichen planus, this maintenance might be impaired by mast cell degranulation and inflammatory cytokines.
Activation of the H4R could induce phosphorylation of ERK (show EPHB2 Antibodies).
Suggest roles for HRH4 polymorphisms and ankylosing spondylitis susceptibility.
Molecular modelling studies, including molecular dynamic simulations and calculation of Gibbs energy of solvation of hH3R (show HRH3 Antibodies) and hH4R, were studied.
HRH4 was increased in clinically-isolated syndrome and different stages of multiple sclerosis compared to health control.
No evidence was found for the presence of histamine H4 receptor in monocytes.
Results illustrate that histamine H4 receptors (H4R) modulates various neurophysiological functions such as locomotor activity, anxiety, nociception and feeding behaviour, confirming the importance of the integrity and functionality of neuronal H4R in the histaminergic regulation of neuronal functions.
These results identify the H4R as a new target controlling NK cell migration and NK cell-dendritic cell interaction in the skin during early allergic inflammation. These results further suggest that blocking the H4R in the skin might be beneficial in diseases like atopic dermatitis.
Histamine H4 receptor knockout mice display reduced inflammation in a chronic model of atopic dermatitis
These results indicate a proinflammatory role of histamine via H4R in inflammatory bowel disease.
The histamine H4 receptor mediates inflammation and Th17 responses in preclinical models of arthritis.
H4R expression on murine keratinocytes was detected after stimulation with LPS (show TLR4 Antibodies) and peptidoglycan.
the present study shows that H4 receptors potentially play a role in IgE induced FcepsilonRI (show FCER1A Antibodies) upregulation
Acting via its H4 receptors, histamine impedes lipopolysaccharide-induced microglia migration and interleukin (IL)-1beta (show IL1B Antibodies) release under inflammatory challenge.
development of allergic rhinitis proceeded in two distinct stages: histamine release from FcepsilonRI (show FCER1A Antibodies)-activated mast cells, followed by histamine-mediated recruitment of H(4)R-expressing basophils to the nasal cavity and activation through FcepsilonRI (show FCER1A Antibodies).
The majority of hypertrophic ATDC5 chondrocytes express H4R, suggesting that this receptor is associated with the differentiation of chondrocytes into hypertrophic cells.
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by a family of histamine receptors, which are a subset of the G-protein coupled receptor superfamily. This gene encodes a histamine receptor that is predominantly expressed in haematopoietic cells. The protein is thought to play a role in inflammation and allergy reponses. Multiple transcript variants encoding different isoforms have been found for this gene.
histamine H4 receptor
, histamine receptor H4
, histamine 4 receptor
, histamine H4 receptor-like
, G-protein coupled receptor 105