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HDC encodes a member of the group II decarboxylase family and forms a homodimer that converts L-histidine to histamine in a pyridoxal phosphate dependent manner. Additionally we are shipping Histidine Decarboxylase Antibodies (60) and Histidine Decarboxylase Proteins (18) and many more products for this protein.
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genes encoding for proteins involved in histamine signaling [histidine decarboxylase (hdc), histamine-gated chloride channel (show CLCA1 ELISA Kits) subunit 1 (hisCl1), ora (show RHO ELISA Kits) transientless (ort)] cause abnormal temperature preferences
Ethanol upregulates histidine decarboxylase expression in neural brain networks.
The H3 receptor is upregulated in the striatum in the Hdc KO mouse model of tic disorders.
Lack of endogenous histamine in NOD HDC(-/-) mice decreased the incidence of diabetes in relation to their wild-type counterpart.
the structure and function of the retina in mice that lacked expression of the rate limiting enzyme in the formation of histamine, histidine decarboxylase (Hdc-/- mouse), were investigated.
SDS (show SDS ELISA Kits) induces itch through increased production of epidermal histamine, which results from an increase in the gene expression and post-translation processing of L-histidine decarboxylase.
HDC, whose expression is remarkably downregulated during the first few days after birth in dermal cells of mice, plays essential roles in the hair-inducing ability of newborn mouse dermal cells
An increased expression of H3 receptors in HDC KO mice without any changes in the spontaneous firing of "histaminergic" neurons without histamine and their responses to the H3 receptor agonist (R)-alpha-methylhistamine.
Histidine decarboxylase was found at comparably high levels in mouse striatum.
There was no difference in the levels of vascular endothelial growth factor between HDC-/- or wild-type mice, either in the lung or in bronchoalveolar-lavage cells.
HDC-/- mice showed reduced severity of K/BxN serum-induced arthritis.
in 12 day old embryonic stem cells histidine decarboxylase was confined to peripheral cells and small clusters of cells, inner cells were usually negative for it
Human histidine decarboxylase (HDC) and dopa decarboxilase (DDC (show DDC ELISA Kits)) are highly homologous enzymes responsible for the synthesis of biogenic amines (BA) like histamine, and serotonin and dopamine, respectively. This review summarizes the analogies and differences in their origin as well as their common pathophysiological scenarios. [review]
a Possible Role for the Histidine Decarboxylase Gene in Tourette Syndrome in the Chinese Han Population
Human enterochromaffin-like cells appear to partially co-express VMAT-2 and HDC. Co-expression of VMAT-2 and HDC might be required for increased histamine production in patients with gastric neuroendocrine tumors.
The findings indicate that polymorphisms of HDC gene were significantly associated with breast cancer in Chinese Han population and may be novel diagnostic or therapeutic targets for breast cancer.
HDC rs17740607 polymorphism is at least a partial loss-of-function variant and acts as a protective factor against chronic heart failure
Investigated variation across the HDC (histidine decarboxylase) gene for association with Tourette Syndrome.
HDC production in the stomach is associated with bile acid exposure and its related transcriptional regulation network of FXR (show NR1H4 ELISA Kits), SHP (show LAMC1 ELISA Kits), and CDX1 (show CDX1 ELISA Kits).
Data indicate that histidine decarboxylase (HDC) is expressed by neutrophils.
Structural study reveals that Ser (show SIGLEC1 ELISA Kits)-354 determines substrate specificity on human histidine decarboxylase.
crystal of histidine decarboxylase belonged to space group C2, with unit-cell parameters a = 215.16, b = 112.72, c = 171.39 A, beta = 110.3 degrees
This gene encodes a member of the group II decarboxylase family and forms a homodimer that converts L-histidine to histamine in a pyridoxal phosphate dependent manner. Histamine regulates several physiologic processes, including neurotransmission, gastric acid secretion,inflamation, and smooth muscle tone.
, histidine decarboxylase
, histidine decarboxylase-like
, headcase protein homolog
, L-histidine decarboxylase