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Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Additionally we are shipping HDAC4 Kits (13) and HDAC4 Proteins (13) and many more products for this protein.
Showing 10 out of 255 products:
Human Polyclonal HDAC4 Primary Antibody for EIA, WB - ABIN493047
Bolden, Peart, Johnstone: Anticancer activities of histone deacetylase inhibitors. in Nature reviews. Drug discovery 2006
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Human Polyclonal HDAC4 Primary Antibody for EIA, WB - ABIN356644
Chan, Sun, Yang, Zhu, Wu: Functional characterization of an amino-terminal region of HDAC4 that possesses MEF2 binding and transcriptional repressive activity. in The Journal of biological chemistry 2003
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Human Monoclonal HDAC4 Primary Antibody for ELISA, WB - ABIN969190
Nishino, Miyazaki, Hoshino, Miwa, Horinouchi, Yoshida: 14-3-3 regulates the nuclear import of class IIa histone deacetylases. in Biochemical and biophysical research communications 2008
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Human Polyclonal HDAC4 Primary Antibody for WB - ABIN196930
Wang, Kruhlak, Wu, Bertos, Vezmar, Posner, Bazett-Jones, Yang: Regulation of histone deacetylase 4 by binding of 14-3-3 proteins. in Molecular and cellular biology 2000
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Human Polyclonal HDAC4 Primary Antibody for IF, WB - ABIN197338
Grozinger, Schreiber: Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization. in Proceedings of the National Academy of Sciences of the United States of America 2000
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Human Polyclonal HDAC4 Primary Antibody for WB - ABIN387951
Kao, McKenna, Guenther, Muschel, Lazar, Yen: Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response. in The Journal of cell biology 2003
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Chicken Polyclonal HDAC4 Primary Antibody for WB - ABIN2778342
Lee, Lin, Luo, Lee, Lee, Aird, Hwang, Yang et al.: Tumor necrosis factor-alpha enhances neutrophil adhesiveness: induction of vascular cell adhesion molecule-1 via activation of Akt and CaM kinase II and modifications of histone acetyltransferase and ... in Molecular pharmacology 2008
Human Polyclonal HDAC4 Primary Antibody for IHC, WB - ABIN223298
Cao, Li, Zhu, Shen, Han, Zhang, Yu, Wang, Wu, Chen, Sun, Tang, Zhao, Qiao, Hou, Mao: The antiparasitic clioquinol induces apoptosis in leukemia and myeloma cells by inhibiting histone deacetylase activity. in The Journal of biological chemistry 2013
RNAi-mediated knockdown of HDAC4 in Drosophila dampens circadian function.
HDAC4 is not only a repressor of long-term memory, but also modulates normal memory formation
dHDAC4, is a novel, catalytically active class II Drosophila histone deacetylase (show HDAC1 Antibodies) and is involved in the segmentation regulatory pathway and suggested complex transcriptional regulation as a potential mechanism that controls its expression
HDAC4 destabilizes MAP1S (show MAP1S Antibodies), suppresses autophagy flux and promotes the accumulation of mHTT aggregates.
Mechanical compression regulates chondrocyte gene expression through HDAC4 relocation from the cell's cytoplasm to the nucleus via PP2A (show PPP2R4 Antibodies)-dependent HDAC4 dephosphorylation.
Elevated HDAC-4 expression in Pancreatic Adenocarcinoma was significantly associated with the absence of organ metastases and borderline with the absence of lymph node metastases and tumor proliferative capacity.
Over-expression of HDAC4 suppressed the transcription of genes involved in energy expenditure in a SIRT1 (show SIRT1 Antibodies)-dependent manner. In contrast, HDAC4 knockdown/inhibition neutralized the effect of IFN-gamma (show IFNG Antibodies) on cellular metabolism by normalizing SIRT1 (show SIRT1 Antibodies) expression
HDAC4-RelB (show RELB Antibodies)-p52 (show FKBP4 Antibodies) complex maintains repressive chromatin around proapoptotic genes Bim (show BCL2L11 Antibodies) and BMF (show BMF Antibodies) and regulates multiple myeloma survival and growth
Among the class II HDACs, HDAC4 interacted with both MR and HDAC3 (show HDAC3 Antibodies) after aldosterone stimulation. The nuclear translocation of HDAC4 was mediated by protein kinase A (PKA) and protein phosphatases (PP)
Results show that overexpression of miR10b in ER-positive breast cancer cell lines led to increased resistance to tamoxifen and HDAC4 was identified as its direct target. MiR10b-HDAC4 nexus may be one of the molecular mechanism of tamoxifen resistance.
the pro-inflammatory role of miR (show MLXIP Antibodies)-22 in emphysema has revealed that HDAC4 specifically regulated smoking-related lung inflammation and TH17 responses
Molecular basis for the specific interactions between HDAC4 and the SMRT (show NCOR2 Antibodies) corepressor.
This study leads to the discovery of a novel molecular mechanism in which the miRNA miR (show MLXIP Antibodies)-125a-5p suppresses HDAC4 expression
postmitotic expression SOD1G93A mutant gene promotes a FAPS phenotype in C2C12 cells, by upregulating HDAC4 (show HDAC5 Antibodies) protein and preventing the BAF60C (show SMARCD3 Antibodies)-SWI (show SMARCA1 Antibodies)/SNF (show SNRPA Antibodies) complex myogenic commitment
miR (show MLXIP Antibodies)-29a was involved in the regulation of HDAC4 (show HDAC5 Antibodies) and modulation of the profibrogenic phenotype in hepatic stellate cells.
This study demonstrated that hdac4 (show HDAC5 Antibodies) increase in skeletal muscle in muscle atrophy.
These results demonstrate that miR (show MLXIP Antibodies)-140 ensures the robustness of the PTHrP (show PTHLH Antibodies)/HDAC4 (show HDAC5 Antibodies) regulatory system by suppressing MEF2C (show MEF2C Antibodies)-inducing stimuli.
The data of this study demonstrated pronounced and distinctively different changes in the expression of class IV HDAC (show HDAC3 Antibodies) in subfields of the hippocampus after an acute status epilepticus, during epileptogenesis and in chronic TLE.
Phosphorylation and localization of HDAC4 (show HDAC5 Antibodies) contributes to establishing fiber type-specific transcriptional programs.
HDAC4 (show HDAC5 Antibodies) is a novel inflammatory pain mediator.
Glycolysis-dependent histone deacetylase 4 (show HDAC5 Antibodies) degradation regulates inflammatory cytokine production.
HDAC4 (show HDAC5 Antibodies) is a novel regulator of Pax7 (show PAX7 Antibodies)-dependent satellite cell proliferation.
Thus, HDAC4 (show HDAC5 Antibodies) contributes to podocyte injury and is one of critical components of a signal transduction pathway that links renal injury to autophagy in diabetic nephropathy.
Results demonstrate that Hdac4 is a regulator of cranial neural crest-derived palatal skeletal precursors during early embryogenesis.
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.
histone deacetylase 4
, histone deacetylase A