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Histone Deacetylase 8 Proteins (HDAC8)

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Additionally we are shipping Histone Deacetylase 8 Antibodies (159) and Histone Deacetylase 8 Kits (13) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HDAC8 55869 Q9BY41
HDAC8 70315 Q8VH37
HDAC8 363481 B1WC68
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Top Histone Deacetylase 8 Proteins at antibodies-online.com

Showing 10 out of 21 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Baculovirus infected Insect Cells Human GST tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Baculovirus infected Insect Cells Mouse His tag 100 μg Log in to see 16 Days
$437.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Sf-9 cells Human His tag 50 μg Log in to see 7 to 8 Days
$407.00
Details
HOST_Escherichia coli (E. coli) Human His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Sf-9 cells Human Un-conjugated 100 μg Log in to see 2 to 3 Days
$546.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,036.00
Details
HOST_Baculovirus Human His tag HDA8 activity assay. Recombinant HDAC8 activity measured using a fluorescent HDAC assay. HDAC8 protein gel. HDAC8 run on an SDS-PAGE gel and stained with Coomassie blue. 50 μg Log in to see 1 to 2 Days
$460.83
Details

HDAC8 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, ,
Mouse (Murine) ,

Rat (Rattus)

Top referenced Histone Deacetylase 8 Proteins

  1. Mouse (Murine) HDAC8 Protein expressed in Baculovirus infected Insect Cells - ABIN2007594 : Hu, Chen, Fredrickson, Zhu, Kirkpatrick, Zhang, Johanson, Sung, Liu, Winkler: Cloning and characterization of a novel human class I histone deacetylase that functions as a transcription repressor. in The Journal of biological chemistry 2000 (PubMed)
    Show all 3 references for ABIN2007594

  2. Human HDAC8 Protein expressed in Baculovirus infected Insect Cells - ABIN2003497 : Buggy, Sideris, Mak, Lorimer, McIntosh, Clark: Cloning and characterization of a novel human histone deacetylase, HDAC8. in The Biochemical journal 2001 (PubMed)
    Show all 3 references for ABIN2003497

More Proteins for Histone Deacetylase 8 (HDAC8) Interaction Partners

Human Histone Deacetylase 8 (HDAC8) interaction partners

  1. study elucidates an HDAC8-mediated p53 (show TP53 Proteins)-inactivating mechanism promoting leukemia stem cells activity

  2. Studies indicate that histone deacetylase 8 protein (HDAC8) aberrantly deacetylates p53 (show TP53 Proteins) protein and promotes leukemia stem cells (LSCs) transformation and maintenance.

  3. Our data exhibited an important role of HDAC8 in promoting gastric cancer tumorigenesis and identify this HDAC8 as a potential therapeutic target for the treatment of gastric cancer.

  4. The H143A and H142A/H143A mutants exhibit activity that is >80000-fold lower than that of wild-type HDAC8; the buried D176N and D176A mutants have significant catalytic effects, with more subtle effects caused by D183N and D183A

  5. cAMP signaling increases HDAC8 protein levels by reducing JNK (show MAPK8 Proteins)-mediated autophagy and ubiquitin-proteasome-dependent degradation of the HDAC8 protein in H1299 lung cancer cells.

  6. Report the preparation and biophysical evaluation of five HDAC8 mutants: P91L, G117E, H180R, D233G, and G304R. Additionally, the double mutants D233G-Y306F and P91L-Y306F were prepared to enable cocrystallization of intact enzyme-substrate complexes.

  7. HDAC8 was increased in BRAF (show BRAF Proteins)-mutated melanoma. Increased cytoplasmic HDAC8 immunoreactivity was independently associated with an improved survival from both diagnosis of primary melanoma and from first detection of stage IV disease to melanoma death

  8. findings show how HDAC8 drives nonalcoholic fatty liver disease-associated hepatocarcinogenesis

  9. Data reveal a role for miR-21-3p in regulating HDAC8 expression and Akt/Gsk3beta pathway in cardiac hypertrophy.

  10. Studied the kinetics, thermodynamics, and selectivity of Zn(II) and Fe(II) binding to HDAC8.

Mouse (Murine) Histone Deacetylase 8 (HDAC8) interaction partners

  1. this study demonstrates a novel role of HDAC8 in LeTx immunotoxicity and regulation of pro-IL-1beta (show IL1B Proteins) production likely through eRNAs.

  2. findings show how HDAC8 drives nonalcoholic fatty liver disease-associated hepatocarcinogenesis

  3. Data reveal a role for miR-21-3p in regulating HDAC8 expression and Akt/Gsk3beta pathway in cardiac hypertrophy.

  4. histone deacetylase 8 inhibition reduces gene expression and production of proinflammatory cytokines in vitro and in vivo

  5. HDAC8 and Sirt1 (show SIRT1 Proteins) were also demonstrated to interact directly with ERRalpha (show ESRRA Proteins) in vivo and to deacetylate and increase the DNA binding affinity of ERRalpha (show ESRRA Proteins) in vitro.

  6. Global deletion of Hdac8 in mice leads to perinatal lethality due to skull instability, and deletion of Hdac8 in cranial neural crest cells and Hdac8 specifically represses the aberrant expression of homeobox (show PRRX1 Proteins) transcription factors such as Otx2 (show OTX2 Proteins) and Lhx1 (show LHX1 Proteins)

Histone Deacetylase 8 (HDAC8) Protein Profile

Protein Summary

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Histone Deacetylase 8 Proteins (HDAC8)

  • histone deacetylase 8 (CC1G_05302)
  • histone deacetylase 8 (hdac8)
  • histone deacetylase 8 (HDAC8)
  • histone deacetylase 8 (Hdac8)
  • histone deacetylase 8 (HDA08)
  • 2610007D20Rik protein
  • ATHDA8 protein
  • CDLS5 protein
  • HD8 protein
  • HDA8 protein
  • HDACL1 protein
  • histone deacetylase 8 protein
  • MRXS6 protein
  • RGD1562895 protein
  • RPD3 protein
  • T27G7.14 protein
  • T27G7_14 protein
  • WTS protein
  • wu:fd19a02 protein
  • zgc:66196 protein

Protein level used designations for Histone Deacetylase 8 Proteins (HDAC8)

histone deacetylase 8 , histone deacetylase-like 1 , HD8

GENE ID SPECIES
6017058 Coprinopsis cinerea okayama7130
100145561 Xenopus (Silurana) tropicalis
55869 Homo sapiens
70315 Mus musculus
363481 Rattus norvegicus
406740 Danio rerio
444137 Xenopus laevis
540666 Bos taurus
480957 Canis lupus familiaris
422182 Gallus gallus
100721893 Cavia porcellus
837366 Arabidopsis thaliana
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