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In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Additionally we are shipping HOXA2 Proteins (8) and many more products for this protein.
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Cow (Bovine) Polyclonal HOXA2 Primary Antibody for WB - ABIN2780802
Alasti, Sadeghi, Sanati, Farhadi, Stollar, Somers, Van Camp: A mutation in HOXA2 is responsible for autosomal-recessive microtia in an Iranian family. in American journal of human genetics 2008
Show all 2 Pubmed References
The role of HOXA2 gene in dominant isolated microtia and the dysmorphogenetic effect of this gene on ear development
5 genomic variants in GSC (show GSC Antibodies), HOXA2 and PRKRA (show PRKRA Antibodies) were identified through mutational analysis in Chinese patients with microtia.
The Hoxa2-mediated decay of RCHY1 (show RCHY1 Antibodies) involves both the 19S and 20S proteasome (show PSMA5 Antibodies) complexes
HOXA2 acts as a suppressor or TBP (show TBP Antibodies)-antagonist to inhibit MMP-9 (show MMP9 Antibodies) expression; while methylation-mediated inactivation of HOXA2 in NPC (show NPC1 Antibodies) derepresses MMP-9 (show MMP9 Antibodies) production and increases invasion of NPC (show NPC1 Antibodies) cells.
we have identified a nonsense mutation (Q235*) in HOXA2 that segregates with bilateral nonsyndromic microtia and hearing loss through three generations of a family in an autosomal dominant pattern.
Lack of mutations in the coding region of HOXA2 among the sporadic microtia patients.
A missense mutation in the HOXA2 in a consanguineous iranian family with bilateral microtia was reported.
These results establish a role for Hox (show MSH2 Antibodies) factors in tonotopic refinement of connectivity and in ensuring the precision of sound transmission in the mammalian auditory circuit.
Hoxa2, Meis and Pbx proteins act cooperatively on the ECR, via a core 32 bp sequence, to regulate Hmx1 expression.
our data support that KPC2 regulates Hoxa2 by promoting its relocation to the cytoplasm.
Ectopic Hoxa2 expression results in the transformation of the proximal Meckel's cartilage and the malleus into a supernumerary styloid process (SP), a second pharyngeal arch-derived mammalian-specific skeletal structure.
Hoxa2 operates as a tissue-specific cofactor, enhancing Meis binding to specific sites that provide the second arch with its anatomical identity
The impairment of chondrogenic differentiation by Hoxa2 overexpression.
Data show that the transcription factor Hoxa2 binds to Pcp4 chromatin and regulates Pcp4 expression in the second arch.
Hoxa2 partly controls the morphogenesis of the pinna through the BMP signalling pathway and expression of Eya1 (show EYA1 Antibodies), which in humans is involved in branchio-oto (show PGAP1 Antibodies)-renal syndrome.
Hoxb2 (show HOXB2 Antibodies) antagonizes Hoxa2 during rostral hindbrain oligodendrogenesis.
the sustained expression of Hoxa2 in the chondrocyte lineage is characterized by a proportionate short stature resulting from skeletal growth defect.
Hoxa2 knockdown in Xenopus results in hyoid to mandibular homeosis.
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. The encoded protein may be involved in the placement of hindbrain segments in the proper location along the anterior-posterior axis during development.
homeobox protein Hox-1K
, homeobox protein Hox-A2
, homeobox A2
, homeobox A1
, homeo box A1
, homeo box A2
, homeobox protein Hox-1.11
, transcription factor Hoxa2b
, transcription factor Hoxa2
, Homeobox protein Hox-A2
, homeobox protein Hox-A2-like
, Homeobox gene A11
, Homeobox gene A2
, Homeobox protein Hox-1.11
, homeo box A2b
, homeobox gene A-2
, homeobox protein Hox-A2b