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Homeobox B4 Proteins (HOXB4)

HOXB4 is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. Additionally we are shipping Homeobox B4 Antibodies (69) and Homeobox B4 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat HOXB4 HOXB4 497988  
HOXB4 3214 P17483
HOXB4 15412 P10284
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Top Homeobox B4 Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$2,585.00
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$2,625.33
Details
HOST_Escherichia coli (E. coli) Human His tag   10 μg Log in to see 5 Days
$154.00
Details

HOXB4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Homeobox B4 (HOXB4) Interaction Partners

Zebrafish Homeobox B4 (HOXB4) interaction partners

  1. the similarity of hoxb3a/Hoxa3 (show HOXA3 Proteins) regulatory mechanisms reflect the shared descent of both genes from a single ancestral paralog, expression of both genes in the posterior hindbrain and spinal cord in embryo

Human Homeobox B4 (HOXB4) interaction partners

  1. The analysis of HOX (show MSH2 Proteins) expression in primary mesothelioma tumors indicated that these cells could also be sensitive to the disruption of HOX (show MSH2 Proteins) activity by HXR9, and that the expression of HOXB4 is strongly associated with overall survival

  2. HOXA4 (show HOXA4 Proteins) increases short-term repopulation to higher levels than HOXB4, which may involve Notch (show NOTCH1 Proteins) signaling to induce self-renewal of primitive hematopoietic cells

  3. showed that OAC1 treatment led to OCT4 (show POU5F1 Proteins)-mediated upregulation of HOXB4

  4. decreased methylation at HOXB3 (show HOXB3 Proteins) and HOXB4 was associated with increased gene expression of both HOXB genes specific to the mid-risk AML (show RUNX1 Proteins), while increased DNA methylation (show HELLS Proteins) at DCC (show DCC Proteins) distinctive to the high-risk AML (show RUNX1 Proteins) was associated with increased gene expression

  5. Epigenetic analysis revealed that increased promoter methylation of HOXB4 correlates with decreased expression of its transcript in oral cancer cell lines. HOXB4 may work as an epigenetic biomarker gene.

  6. Our study demonstrates for the first time the regulation of HOXB4 by miR (show MLXIP Proteins)-23a

  7. our results outline the effects of HOXB4 in combination with stromal cells in the development of NK cells from embryonic stem cells.

  8. GATA-2 (show GATA2 Proteins) directly regulates HOXB4 expression in hematopoietic stem cells, which may play an important role in the development and/or progression of aplastic anemia.

  9. HOXB4-positivity as an independent predictor of overall survival of acute myeloid leukemia (show BCL11A Proteins) patients

  10. Expressions of ABCB1 (show ABCB1 Proteins), BMI-1 (show BMI1 Proteins), HOXB4 were not detected in the patients with non-malignant hematologic diseases, but were higher in de novo acute leukemia patients and lower in patients in complete remission.

Mouse (Murine) Homeobox B4 (HOXB4) interaction partners

  1. Data suggest that the homeobox B4 protein (HoxB4) and signal transducer and activator of transcription 3 (STAT3 (show STAT3 Proteins)) signals are functionally redundant for hematopoietic stem cells (HSCs) self-renewal rather than exerting independent effects.

  2. these studies define the transcriptional pathways involved in HOXB4 HSC (show FUT1 Proteins) expansion in vivo and identify repression of Prdm16 (show PRDM16 Proteins) transcription as a mechanism by which expanding HSCs avoid leukemic transformation.

  3. Hoxb4 favours the maintenance and increase of the CD4 (show CD4 Proteins) central memory phenotype T cell population.

  4. The results show a novel role for DNA methylation (show HELLS Proteins) in the alternative promoter usage at the Runx1 (show RUNX1 Proteins) locus and identify HOXB4 as a direct activator of the Runx1 (show RUNX1 Proteins) P1 promoter.

  5. Loss of Scmh1 (show SCMH1 Proteins) caused derepression of Hoxb4 and Hoxa9 (show HOXA9 Proteins), direct targets of Polycomb (show CBX2 Proteins)-group complex 1-mediated transcriptional silencing in hematopoietic cells.

  6. HOXB4 activation can generate a paracrine as well as a cell autonomous effect on hematopoietic differentiation.

  7. HoxB4 reprograms a set of key regulator genes to facilitate the maturation of developing hematopoietic stem cells into repopulating cells

  8. Hoxb4 expression therefore would not appear to correlate with the cycling status of fetal liver hematopoietic stem cells(HSCs), although highly proliferative HSCs from young BM show strong Hoxb4 expression.

  9. Data suggest that transduced Hoxb4 down-regulates Geminin protein (show GMNN Proteins) probably by constituting the E3 ubiquitin ligase (show MUL1 Proteins) for Geminin (show GMNN Proteins) to provide hematopoietic stem and progenitor cells with proliferation potential.

  10. Results compare the hematopoietic inductive effects of stromal cell lines derived from different subregions of the embryonic aorta-gonad-mesonephros tissue with the commonly used OP9 stromal cell line and with HOXB4 activation.

Homeobox B4 (HOXB4) Protein Profile

Protein Summary

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion.

Gene names and symbols associated with Homeobox B4 Proteins (HOXB4)

  • homeobox B4 (hoxb4)
  • homeobox B4 (HOXB4)
  • hox4 protein (hox4)
  • hoxb4a protein (hoxb4a)
  • homeo box B4 (Hoxb4)
  • homeo box B4a (hoxb4a)
  • homeobox B4 (Hoxb4)
  • Chox-Z protein
  • Hox-2.6 protein
  • HOX-B4 protein
  • HOX2 protein
  • HOX2F protein
  • hoxb4 protein
  • RGD1560113 protein
  • XHox-b4 protein
  • Z-17 protein
  • ZF-13 protein
  • zf13 protein

Protein level used designations for Homeobox B4 Proteins (HOXB4)

homeobox B4 , homeo box B4 , hox4 protein , hoxb4a protein , Hoxb4a variant 2 , etID309956.3 , homeobox gene B-4 , homeobox protein Hox-B4a , homeobox protein Zf-13 , homeo box 2F , homeobox protein Hox-2.6 , homeobox protein Hox-2F , homeobox protein Hox-B4 , homeobox protein Hox-Z , xhox-1A

GENE ID SPECIES
548393 Xenopus (Silurana) tropicalis
749218 Pan troglodytes
445807 Ciona intestinalis
100049485 Oryzias latipes
497988 Rattus norvegicus
30340 Danio rerio
3214 Homo sapiens
15412 Mus musculus
608915 Canis lupus familiaris
768240 Bos taurus
396230 Gallus gallus
734796 Xenopus laevis
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