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HOXB8 is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. Additionally we are shipping HOXB8 Antibodies (67) and many more products for this protein.
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Knockdown of ZEB2 can inhibit HOXB8-induced migration and invasion capacity, as well as the epithelial-mesenchymal transformation in gastric cancer cells. The results showed that HOXB8 plays an important role in the development and metastasis of gastric carcinoma
Results show that FMRP (show FMR1 Proteins) regulates miR196a-mediated repression of HOXB8 via interaction with the AGO2 (show EIF2C2 Proteins) MID domain.
HOXB8 and KLK11 (show KLK11 Proteins) may be classified as valuable biomarkers, as they can predict the effects of FOLFOX4 chemotherapy in primary advanced colorectal cancer patients
HOXB5 (show HOXB5 Proteins) and HOXB8 are frequently expressed in ovarian serous carcinoma, with anatomic site-related differences for cytoplasmic staining. HOXB8 expression is associated with shorter survival in metastatic serous carcinoma.
Production and Functional Characterization of Murine Osteoclasts Differentiated from ER-Hoxb8-Immortalized Myeloid Progenitor Cells
results demonstrate an important role for the intersection of Lmx1b (show LMX1B Proteins) and Hoxb8::cre expression in the development of nociceptive dorsal horn circuits critical for mechanical and thermal pain processing.
Results show a previously unrecognised link between Hoxb8 expression and microRNAs that provides a new insight into the oncogenic functions of Hoxb8.
Mouse Hoxb8 mutants show unexpected behavior manifested by compulsive grooming and hair removal further, transplantation of wild-type bone marrow into Hoxb8 mutant mice rescues their pathological phenotype.
Data sugest that cooperative binding between Hoxb8 hexapeptide motif and cofactors is a critical element in the fine-tuning of Hoxb8 protein target specificity.
RNA fragments diagnostic of miR (show MLXIP Proteins)-196-directed cleavage of HOXB8 were detected in mouse embryos; results point to a miRNA-mediated mechanism for the posttranscriptional restriction of HOX (show MSH2 Proteins) gene expression during vertebrate development
Hoxb8 inhibited the activity of the telokin (show MYLK Proteins), SM22alpha (show TAGLN Proteins), and smooth muscle alpha-actin (show ACTA2 Proteins) promoters
miR (show MLXIP Proteins)-196 acts upstream of Hoxb8 and Sonic hedgehog (Shh (show SHH Proteins)) in vivo in the context of limb development, thereby identifying a previously observed but uncharacterized inhibitory activity that operates specifically in the hindlimb
Results indicate distinct roles for class 2 Polycomb (show CBX2 Proteins) group complexes in transcriptionally repressed and active domains of Hoxb8 gene.
These results suggest that miR (show MLXIP Proteins)-196 participates in myeloid differentiation of HL60 cells via regulation of HOXB8 expression.
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with colorectal cancer. Mice that have had the murine ortholog of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the behavior of humans suffering from the obsessive-compulsive spectrum disorder trichotillomania.
Hox2.4 homeobox homolog
, homeobox gene B8
, homeobox protein Hox-B8
, homeobox protein R1a
, homeo box 2D
, homeo box B8
, homeobox protein Hox-2.4
, homeobox protein Hox-2D