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HOXD10 is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. Additionally we are shipping HOXD10 Antibodies (71) and HOXD10 Kits (3) and many more products for this protein.
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Knock down of the dickkopf (show DKK1 Proteins) WNT (show WNT2 Proteins) signaling pathway inhibitor 2 (DKK2 (show DKK2 Proteins)) resulted in a significant suppression of HOXD10, HOXD11 (show HOXD11 Proteins) and HOXD13 (show HOXD13 Proteins) while over-expression of DKK2 (show DKK2 Proteins) and stimulation with factors of the WNT (show WNT2 Proteins) signaling pathway.
By treating LECs with VEGF (show VEGFA Proteins)-C156S and analyzing subsequent changes in gene expression, we identified several 'immediate early (show JUN Proteins)' transcription factors that showed a rapid transient upregulation VEGFR-3 (show FLT4 Proteins) stimulation. these results reveal an important and unanticipated role of HOXD10 in the regulation of VEGFR-3 (show FLT4 Proteins) signaling in lymphatic endothelial cells, and in the control of lymphangiogenesis and permeability.
Knockdown of HOXD10 in renal cells also resulted in increased resistance to colistin cytotoxicity.
High expression of HOXD10 is associated with laryngeal squamous cell carcinoma.
Low HOXD10 promotes migration and invasion in gastric cancer.
These results suggested that HOXD10 may be a putative suppressor gene and can act as a prognostic marker and potentially a novel therapeutic target for cholangiocellular carcinoma.
miR (show MLXIP Proteins)-23a was upregulated in glioma. This overexpression promoted glioma cell invasion, probably by modulating MMP-14 (show MMP14 Proteins) via directly inhibiting the expression of HOXD10.
POU2F1 (show POU2F1 Proteins) activity regulates HOXD10 and HOXD11 (show HOXD11 Proteins) gene expression in head and neck squamous cell carcinoma, promoting a proliferative and invasive phenotype.
Downregulation of the HOXD10 gene expression was associated with breast cancer.
KLF4 (show KLF4 Proteins) and HOXD10 were identified as direct targets of miR (show MLXIP Proteins)-10b in bladder cancer cells
The organization and distribution of lumbar motor neurons was examined in the spinal cords of Hoxd10/Hoxa10 (show HOXA10 Proteins) double mutant animals. Double mutant mice have decreased numbers of lumbar motor neurons in both the medial and lateral motor columns.
show that the intracellular domain of Notch1 (show NOTCH1 Proteins), transcription factor Ets (show ETV7 Proteins)-1 (show ETS1 Proteins), and homeo box D10 (HOXD10).pre B-cell leukemia transcription factor 1(PBX1b (show PBX1 Proteins)).PREP1 activate the rat renin (show REN Proteins) promoter cooperatively
The three paralogous genes, Hoxa10 (show HOXA10 Proteins), Hoxc10 (show HOXC10 Proteins), and Hoxd10, are all expressed in the lumbar spinal cord and have distinct expression patterns
Gli3 (show GLI3 Proteins) mutant limbs are characterized by a severe polydactyly and associated ectopic anterior expression of 5'Hoxd genes.
Hoxc10 (show HOXC10 Proteins) and Hoxd10 play key roles in establishing lumbar motoneuron columnar, divisional and motor pool identity
This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development. Mutations in this gene have been associated with Wilm's tumor and congenital vertical talus (also known as 'rocker-bottom foot' deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease.
, homeo box D10
, homeobox protein, Hoxd10
, homeobox protein Hox-D10
, homeobox protein Hox-D10-like
, homeobox gene D-10
, homeobox protein Hox-C10
, homeobox protein Hox-D10a
, homeo box 4D
, homeobox protein Hox-4D
, homeobox protein Hox-4E
, homeobox protein Hox-4.5
, homeobox protein Hox-5.3