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Homer Homolog 3 (Drosophila) Proteins (HOMER3)

HOMER3 encodes a member of the HOMER family of postsynaptic density scaffolding proteins that share a similar domain structure consisting of an N-terminal Enabled/vasodilator-stimulated phosphoprotein homology 1 domain which mediates protein-protein interactions, and a carboxy-terminal coiled-coil domain and two leucine zipper motifs that are involved in self-oligomerization. Additionally we are shipping HOMER3 Antibodies (66) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HOMER3 9454 Q9NSC5
HOMER3 26558 Q99JP6
Rat HOMER3 HOMER3 29548 Q9Z2X5
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Top HOMER3 Proteins at antibodies-online.com

Showing 6 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$382.86
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

HOMER3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Top referenced HOMER3 Proteins

  1. Human HOMER3 Protein expressed in Escherichia coli (E. coli) - ABIN1098620 : Mayya, Lundgren, Hwang, Rezaul, Wu, Eng, Rodionov, Han: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. in Science signaling 2009 (PubMed)
    Show all 2 references for ABIN1098620

More Proteins for Homer Homolog 3 (Drosophila) (HOMER3) Interaction Partners

Human Homer Homolog 3 (Drosophila) (HOMER3) interaction partners

  1. Homer3 acts as a scaffold that spatially organizes actin assembly to support neutrophil polarity and motility downstream of GPCR activation.

  2. Interaction of the protein with amyloid precursor protein (show APP Proteins) is regulated by calcium homeostasis.

  3. Loss of Homer3 is associated with acute myeloid leukemia (show BCL11A Proteins).

  4. Homer3 specifically associates with a novel ubiquitin-like domain in the I kappa B kinase (IKK) beta (show IKBKB Proteins) subunit (show POLG Proteins) of the IKK (show CHUK Proteins) complex.

  5. Homer-3 may be involved in the regulation of SRE activation in T cells via interaction between its EVH1 domain and C/EBP beta (show CEBPB Proteins).

  6. Fat1 exhibit co-localisation with Homer-3 in cellular protrusions and at the plasma membrane of HeLa cells

  7. study found that Homer2 (show HOMER2 Proteins) and Homer3 are negative regulators of T cell activation; this is achieved through binding of nuclear factor of activated T cells (NFAT (show NFATC1 Proteins)) and by competing with calcineurin (show PPP3CA Proteins)

Mouse (Murine) Homer Homolog 3 (Drosophila) (HOMER3) interaction partners

  1. impaired mTORC1-Homer-3 activity underlies PC susceptibility in Spinocerebellar ataxia (show USP14 Proteins) type 1 and presents a promising therapeutic target

  2. Expression of Homer (show HOMER1 Proteins) 3a/b is restricted to the developing cerebellum, hippocampus, and neonatal olfactory bulb, and is concentrated in the dendritic spines of Purkinje cells and their axons.

  3. study found that Homer2 (show HOMER2 Proteins) and Homer3 are negative regulators of T cell activation; this is achieved through binding of nuclear factor of activated T cells (NFAT (show NFATC1 Proteins)) and by competing with calcineurin (show PPP3CA Proteins)

  4. Homer2 (show HOMER2 Proteins) and Homer3 proteins interact specifically with amyloid precursor protein (APP (show APP Proteins)) by inhibiting APP (show APP Proteins) processing and reducing secretion of Abeta (show APP Proteins) peptides.

  5. Homer3 in Purkinje cells might function as a reversible coupler regulated by CaMKII (show CAMK2G Proteins) phosphorylation and that the phosphorylation is capable of regulating the postsynaptic molecular architecture in response to synaptic activity.

HOMER3 Protein Profile

Protein Summary

This gene encodes a member of the HOMER family of postsynaptic density scaffolding proteins that share a similar domain structure consisting of an N-terminal Enabled/vasodilator-stimulated phosphoprotein homology 1 domain which mediates protein-protein interactions, and a carboxy-terminal coiled-coil domain and two leucine zipper motifs that are involved in self-oligomerization. The encoded protein binds numerous other proteins including group I metabotropic glutamate receptors, inositol 1,4,5-trisphosphate receptors and amyloid precursor proteins and has been implicated in diverse biological functions such as neuronal signaling, T-cell activation and trafficking of amyloid beta peptides. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with HOMER3

  • homer homolog 3 (Drosophila) (homer3)
  • homer homolog 3 (Drosophila) (HOMER3)
  • homer homolog 3 (Drosophila) (Homer3)
  • AW146114 protein
  • HOMER-3 protein
  • Vesl-3 protein
  • VESL3 protein
  • zgc:55557 protein

Protein level used designations for HOMER3

homer protein homolog 3 , Homer, neuronal immediate early gene, 3 , homer homolog 3 (Drosophila) , homer, neuronal immediate early gene, 3 , homer-3 , VASP/Ena-related gene up-regulated during seizure and LTP 3

GENE ID SPECIES
394088 Danio rerio
736171 Pan troglodytes
100605039 Nomascus leucogenys
9454 Homo sapiens
26558 Mus musculus
29548 Rattus norvegicus
420115 Gallus gallus
484813 Canis lupus familiaris
508124 Bos taurus
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