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Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. Additionally we are shipping HAP1 Kits (4) and HAP1 Proteins (3) and many more products for this protein.
Showing 10 out of 82 products:
Human Monoclonal HAP1 Primary Antibody for ICC, FACS - ABIN259097
Chan, Nasir, Gutekunst, Coleman, Maclean, Maas, Metzler, Gertsenstein, Ross, Nagy, Hayden: Targeted disruption of Huntingtin-associated protein-1 (Hap1) results in postnatal death due to depressed feeding behavior. in Human molecular genetics 2002
Show all 6 references for ABIN259097
Mouse (Murine) Monoclonal HAP1 Primary Antibody for IF, WB - ABIN968461
Gutekunst, Li, Yi, Ferrante, Li, Hersch: The cellular and subcellular localization of huntingtin-associated protein 1 (HAP1): comparison with huntingtin in rat and human. in The Journal of neuroscience : the official journal of the Society for Neuroscience 1998
Show all 5 references for ABIN968461
Mouse (Murine) Polyclonal HAP1 Primary Antibody for EIA, WB - ABIN615992
Rong, McGuire, Fang, Sheng, Shin, Li, Li: Regulation of intracellular trafficking of huntingtin-associated protein-1 is critical for TrkA protein levels and neurite outgrowth. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2006
Show all 2 references for ABIN615992
Human Polyclonal HAP1 Primary Antibody for ELISA, WB - ABIN188689
Takeshita, Fujinaga, Zhao, Yanai, Shinoda: Huntingtin-associated protein 1 (HAP1) interacts with androgen receptor (AR) and suppresses SBMA-mutant-AR-induced apoptosis. in Human molecular genetics 2006
Results show the stimulatory effect of PARP-1 (show PARP1 Antibodies) on APE1 (show APEX1 Antibodies)-dependent base excision repair (BER). PARP-1 (show PARP1 Antibodies) and APE1 (show APEX1 Antibodies) appear to have a functional interaction in BER since PARP-1 (show PARP1 Antibodies) can stimulate the strand incision activity of APE1 (show APEX1 Antibodies).
Early loss of Hap1 significantly reduces postnatal hippocampal neurogenesis, and leads to adult depressive-like behavior.
Hap1 interacts with Bcr (show BCR Antibodies) on microtubules to regulate neuronal differentiation.
increases in APEX1 (show APEX1 Antibodies) level confer protection against the murine paternal age effect, thus highlighting the role of APEX1 (show APEX1 Antibodies) in preserving reproductive health with increasing age and in protection against genotoxin-induced mutagenesis in somatic cells
Endothelial cell tumor proliferation was found to be dependent on Apex-1 (show APEX1 Antibodies) expression.
Expression of OGG1 (show OGG1 Antibodies) and APEX1 (show APEX1 Antibodies) was decreased at 3h after last exposure to Aroclor 1254 and only the expression level of APEX1 (show APEX1 Antibodies) was recovered at 24-h after, so inhibition of DNA repair can be a potential mode of action of Aroclor 1254 gonadal toxicity.
Data indicate that the endonuclease activity of APE1 (show APEX1 Antibodies) is required for class switch recombination (CSR (show SCARA3 Antibodies)).
These results suggest that mitochondrial APE1/Ref-1 (show APEX1 Antibodies) is contributed to the protective role to protein kinase C (show PKC Antibodies)-induced mitochondrial dysfunction in endothelial cells.
Spinal motor neurones down-regulate APE1 (show APEX1 Antibodies) upon oxidative stress. This property renders motor neurones susceptible to continuous challenge of oxidative stress in pathological conditions.
The reductive activation of endothelial SIRT1 (show SIRT1 Antibodies) by APE1/Ref-1 (show APEX1 Antibodies) mediates the effect of APE1/Ref-1 (show APEX1 Antibodies) on eNOS (show NOS3 Antibodies) acetylation, promoting endothelium-derived NO and endothelium-dependent vasorelaxation.
data fully support that HAP1 (show APEX1 Antibodies) is a GKAP (show DLGAP1 Antibodies), anchoring specifically to the cGMP-dependent protein kinase (show CDK7 Antibodies) isoform Ibeta, and provide further evidence that also PKG (show PRKG1 Antibodies) spatiotemporal signaling is largely controlled by anchoring proteins
HAP1 (show APEX1 Antibodies) gene expression is related to the radiosensitivity of breast cancer cells and may play an important role in the regulation of cellular radiosensitivity
Overexpression of HAP1 (show APEX1 Antibodies) reduced in vitro cell growth in breast cancer cell lines.
The results of this study found no association was found between the HAP1 (show APEX1 Antibodies) T441M polymorphism and the age at onset of Huntington's disease .
The results of this study suggested that HAP1 (show APEX1 Antibodies) co-localizes and associates with APP (show APP Antibodies) in physiological conditions of mouse and human brain.
WT HTT (show HTT Antibodies) regulates ciliogenesis by interacting through huntingtin-associated protein 1 (HAP1) with pericentriolar material 1 protein (PCM1 (show PCM1 Antibodies)).
HAP1 (show APEX1 Antibodies)/stigmoid body interacts with the normal ataxin-3 (show ATXN3 Antibodies) through Josephin (show ATXN3 Antibodies) domain
sortilin (show SORT1 Antibodies) stabilizes the proBDNF.HAP1 complex
ADORA2A (show ADORA2A Antibodies), but not HAP1 (show APEX1 Antibodies) or OGG1 (show OGG1 Antibodies), may have a role in age at onset in Huntington's disease
REVIEW: function of HAP1 (show APEX1 Antibodies)
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.
AP endonuclease 1
, APEX nuclease
, DNA-(apurinic or apyrimidinic site) lyase
, apurinic-apyrimidinic endonuclease 1
, redox factor-1
, huntingtin-associated protein 2
, neuroan 1
, huntingtin-associated protein 1 (neuroan 1)