You are viewing an incomplete version of our website. Please click to reload the website as full version.

anti-Huntingtin Associated Protein 1 (HAP1) Antibodies

Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. Additionally we are shipping HAP1 Kits (4) and HAP1 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
HAP1 11792 P28352
HAP1 9001 P54257
HAP1 29430 P54256
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top anti-HAP1 Antibodies at antibodies-online.com

Showing 10 out of 67 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Mouse Goat Un-conjugated EIA, WB AP23773PU-N HAP-1 antibody staining of Mouse Brain lysate at 0.1 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Goat Un-conjugated ELISA, WB ABIN334416 (0.1µg/ml) staining of Human Brain (Hippocampus) lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 4 to 5 Days
$318.20
Details
Mouse Mouse Un-conjugated IF, WB Western blot analysis of HAP1 on a rat cerebrum lysate. Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of the anti- HAP1 antibody. Immunoflourescence staining of PC12 cells (rat neuroblastoma, ATCC CRL 1721). 50 μg Log in to see 5 to 6 Days
$205.42
Details
Mouse Goat Un-conjugated ELISA, WB   100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Rabbit Un-conjugated EIA, IHC (p) 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Goat Un-conjugated EIA, WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated IHC (p), WB Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with HAP1 antibody ABIN213931 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated IHC (p), WB 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry of HAP1 in human brain tissue with HAP1 antibody at 2.5 μg/ml. Western blot analysis of HAP1 in mouse brain tissue lysate with AP30391PU-N HAP1 antibody at (A) 0.5 and (B) 1 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details

HAP1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine) ,
, ,
,
, , , , ,
Human , ,
, ,
,
, , , , ,
Rat (Rattus) ,
, ,
,

Top referenced anti-HAP1 Antibodies

  1. Mouse (Murine) Monoclonal HAP1 Primary Antibody for IF, WB - ABIN968461 : Gutekunst, Li, Yi, Ferrante, Li, Hersch: The cellular and subcellular localization of huntingtin-associated protein 1 (HAP1): comparison with huntingtin in rat and human. in The Journal of neuroscience : the official journal of the Society for Neuroscience 1998 (PubMed)
    Show all 5 references for ABIN968461

  2. Mouse (Murine) Polyclonal HAP1 Primary Antibody for EIA, WB - ABIN615992 : Rong, McGuire, Fang, Sheng, Shin, Li, Li: Regulation of intracellular trafficking of huntingtin-associated protein-1 is critical for TrkA protein levels and neurite outgrowth. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 (PubMed)
    Show all 2 references for ABIN615992

  3. Human Polyclonal HAP1 Primary Antibody for ELISA, WB - ABIN334416 : Takeshita, Fujinaga, Zhao, Yanai, Shinoda: Huntingtin-associated protein 1 (HAP1) interacts with androgen receptor (AR) and suppresses SBMA-mutant-AR-induced apoptosis. in Human molecular genetics 2006 (PubMed)

More Antibodies against HAP1 Interaction Partners

Mouse (Murine) Huntingtin Associated Protein 1 (HAP1) interaction partners

  1. Results show the stimulatory effect of PARP-1 (show PARP1 Antibodies) on APE1 (show APEX1 Antibodies)-dependent base excision repair (BER). PARP-1 (show PARP1 Antibodies) and APE1 (show APEX1 Antibodies) appear to have a functional interaction in BER since PARP-1 (show PARP1 Antibodies) can stimulate the strand incision activity of APE1 (show APEX1 Antibodies).

  2. Early loss of Hap1 significantly reduces postnatal hippocampal neurogenesis, and leads to adult depressive-like behavior.

  3. Hap1 interacts with Bcr (show BCR Antibodies) on microtubules to regulate neuronal differentiation.

  4. increases in APEX1 (show APEX1 Antibodies) level confer protection against the murine paternal age effect, thus highlighting the role of APEX1 (show APEX1 Antibodies) in preserving reproductive health with increasing age and in protection against genotoxin-induced mutagenesis in somatic cells

  5. Endothelial cell tumor proliferation was found to be dependent on Apex-1 (show APEX1 Antibodies) expression.

  6. Expression of OGG1 (show OGG1 Antibodies) and APEX1 (show APEX1 Antibodies) was decreased at 3h after last exposure to Aroclor 1254 and only the expression level of APEX1 (show APEX1 Antibodies) was recovered at 24-h after, so inhibition of DNA repair can be a potential mode of action of Aroclor 1254 gonadal toxicity.

  7. Data indicate that the endonuclease activity of APE1 (show APEX1 Antibodies) is required for class switch recombination (CSR (show SCARA3 Antibodies)).

  8. These results suggest that mitochondrial APE1/Ref-1 (show APEX1 Antibodies) is contributed to the protective role to protein kinase C (show PKC Antibodies)-induced mitochondrial dysfunction in endothelial cells.

  9. Spinal motor neurones down-regulate APE1 (show APEX1 Antibodies) upon oxidative stress. This property renders motor neurones susceptible to continuous challenge of oxidative stress in pathological conditions.

  10. The reductive activation of endothelial SIRT1 (show SIRT1 Antibodies) by APE1/Ref-1 (show APEX1 Antibodies) mediates the effect of APE1/Ref-1 (show APEX1 Antibodies) on eNOS (show NOS3 Antibodies) acetylation, promoting endothelium-derived NO and endothelium-dependent vasorelaxation.

Human Huntingtin Associated Protein 1 (HAP1) interaction partners

  1. data fully support that HAP1 (show APEX1 Antibodies) is a GKAP (show DLGAP1 Antibodies), anchoring specifically to the cGMP-dependent protein kinase (show CDK7 Antibodies) isoform Ibeta, and provide further evidence that also PKG (show PRKG1 Antibodies) spatiotemporal signaling is largely controlled by anchoring proteins

  2. HAP1 (show APEX1 Antibodies) gene expression is related to the radiosensitivity of breast cancer cells and may play an important role in the regulation of cellular radiosensitivity

  3. Overexpression of HAP1 (show APEX1 Antibodies) reduced in vitro cell growth in breast cancer cell lines.

  4. The results of this study found no association was found between the HAP1 (show APEX1 Antibodies) T441M polymorphism and the age at onset of Huntington's disease .

  5. The results of this study suggested that HAP1 (show APEX1 Antibodies) co-localizes and associates with APP (show APP Antibodies) in physiological conditions of mouse and human brain.

  6. WT HTT (show HTT Antibodies) regulates ciliogenesis by interacting through huntingtin-associated protein 1 (HAP1) with pericentriolar material 1 protein (PCM1 (show PCM1 Antibodies)).

  7. HAP1 (show APEX1 Antibodies)/stigmoid body interacts with the normal ataxin-3 (show ATXN3 Antibodies) through Josephin (show ATXN3 Antibodies) domain

  8. sortilin (show SORT1 Antibodies) stabilizes the proBDNF.HAP1 complex

  9. ADORA2A (show ADORA2A Antibodies), but not HAP1 (show APEX1 Antibodies) or OGG1 (show OGG1 Antibodies), may have a role in age at onset in Huntington's disease

  10. REVIEW: function of HAP1 (show APEX1 Antibodies)

HAP1 Antigen Profile

Protein Summary

Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with HAP1

  • apurinic/apyrimidinic endonuclease 1 (Apex1) antibody
  • huntingtin-associated protein 1 (HAP1) antibody
  • huntingtin-associated protein 1 (Hap1) antibody
  • APE antibody
  • Apex antibody
  • HAP-1 antibody
  • HAP1 antibody
  • HAP1-A antibody
  • HAP1-B antibody
  • HAP2 antibody
  • hHLP1 antibody
  • HIP5 antibody
  • HLP antibody
  • Ref-1 antibody

Protein level used designations for HAP1

AP endonuclease 1 , APEN , APEX nuclease , DNA-(apurinic or apyrimidinic site) lyase , apurinic-apyrimidinic endonuclease 1 , redox factor-1 , HAP-1 , huntingtin-associated protein 2 , neuroan 1 , huntingtin-associated protein 1 (neuroan 1)

GENE ID SPECIES
11792 Mus musculus
9001 Homo sapiens
15114 Mus musculus
29430 Rattus norvegicus
607751 Canis lupus familiaris
618422 Bos taurus
Selected quality suppliers for anti-HAP1 (HAP1) Antibodies
Did you look for something else?