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HIF1AN encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. Additionally we are shipping and and many more products for this protein.
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Human Polyclonal HIF1AN Primary Antibody for EM, ICC - ABIN151887
Birle, Hedley: Suppression of the hypoxia-inducible factor-1 response in cervical carcinoma xenografts by proteasome inhibitors. in Cancer research 2007
Show all 20 references for ABIN151887
Human Monoclonal HIF1AN Primary Antibody for ICC, IF - ABIN440718
Cockman, Lancaster, Stolze, Hewitson, McDonough, Coleman, Coles, Yu, Hay, Ley, Pugh, Oldham, Masson, Schofield, Ratcliffe: Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH). in Proceedings of the National Academy of Sciences of the United States of America 2006
Show all 7 references for ABIN440718
Human Monoclonal HIF1AN Primary Antibody for ICC, IF - ABIN863094
Soilleux, Turley, Tian, Pugh, Gatter, Harris: Use of novel monoclonal antibodies to determine the expression and distribution of the hypoxia regulatory factors PHD-1, PHD-2, PHD-3 and FIH in normal and neoplastic human tissues. in Histopathology 2005
Show all 3 references for ABIN863094
Cow (Bovine) Polyclonal HIF1AN Primary Antibody for WB - ABIN2777654
Linke, Stojkoski, Kewley, Booker, Whitelaw, Peet: Substrate requirements of the oxygen-sensing asparaginyl hydroxylase factor-inhibiting hypoxia-inducible factor. in The Journal of biological chemistry 2004
Cow (Bovine) Polyclonal HIF1AN Primary Antibody for WB - ABIN2781044
Jacobs, Hsing, Bain, Stevens, Wang, Chen, Chanock, Zheng, Xu, Thun, Calle, Rodriguez: Polymorphisms in angiogenesis-related genes and prostate cancer. in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008
the levels of both miR (show MLXIP Antibodies)-182 and HIF1alpha (show HIF1A Antibodies) were elevated, while the expression PHD2 (show EGLN1 Antibodies) and FIH1 was downregulated in a mouse model of prostate cancer.
OTUB1 (show OTUB1 Antibodies) is a target for functional hydroxylation by FIH (show CASR Antibodies).
demonstrates that miR (show MLXIP Antibodies)-135b regulates ERalpha (show ESR1 Antibodies), AR and HIF1AN protein levels through interaction with their 3'UTR (show UTS2R Antibodies) regions, and proliferation in ERalpha (show ESR1 Antibodies)-positive BCa (show BLNK Antibodies) and AR-positive PCa (show FLVCR1 Antibodies) cells
Hypoxia, FIH (show CASR Antibodies) inhibitors and mutation of asparagine 242 all potentiated TRPV3 (show TRPV3 Antibodies)-mediated current, without altering TRPV3 (show TRPV3 Antibodies) protein levels, indicating that oxygen-dependent hydroxylation inhibits TRPV3 (show TRPV3 Antibodies) activity.
the nuclear entry of FIH-1 depends on HIF-1alpha (show HIF1A Antibodies)
The kinetic properties of PHD2 (show EGLN1 Antibodies) and FIH (show CASR Antibodies) with respect to oxygen reflect their cellular hypoxia-sensing ability.
data support the concept that FIH-1 may interact with Notch2 (show NOTCH2 Antibodies) and repress its activity, thereby playing a critical role in controlling the survival of vascular endothelial cells
miR (show MLXIP Antibodies)-31/FIH1 pathway associates with liver fibrosis, perhaps by participation in the TGF-beta (show TGFB1 Antibodies)/Smad3 (show SMAD3 Antibodies) signalling of hepatic stellate cells.
The association between EGLN1 and HIF-1AN single nucleotide polymorphisms and acute mountain sickness in a Han Chinese population, was examined.
FIH (show CASR Antibodies) follows the consensus mechanism for alphaKG oxygenases, suggesting that FIH (show CASR Antibodies) may be an ideal enzyme to directly access steps involved in O2 activation among the broad family of alphaKG oxygenases.
FIH-1 has a role in disrupting the LRRK1/EGFR (show EGFR Antibodies) complex to positively regulate keratinocyte migration
gankyrin binds to and sequester factor inhibiting hypoxia-inducible factor-1 (FIH-1), which results in decreased interaction between FIH-1 and hypoxia-inducible factor-1alpha (HIF-1alpha) and increased activity of HIF-1 to promote VEGF production.
Our results define a previously unknown mechanism for keratinocyte fate decisions where Notch (show NOTCH1 Antibodies) signaling potential is, in part, controlled through a miR (show MLXIP Antibodies)-31/FIH-1 nexus.
Overexpression of factor inhibiting HIF-1 enhances vessel maturation and tumor growth via platelet-derived growth factor-C (show PDGFC Antibodies) in osteosarcoma.
FIH (show CASR Antibodies) recognizes distinct molecular features within HIF-alpha1 versus ankyrin repeat containing substrates Notch1 (show NOTCH1 Antibodies)/4 and Gankyrin (show PSMD10 Antibodies).
FIH1 appears to be a suppressor of oxygen-dependent genes in the kidney, operating through HIF-dependent and -independent mechanisms.
Lackin of hypoxia-inducible factor 1 alpha subunit inhibitor exhibit reduced body weight, elevated metabolic rate, hyperventilation, and improved glucose and lipid homeostasis and are resistant to high-fat-diet-induced weight gain and hepatic steatosis.
This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
hypoxia-inducible factor 1 alpha
, hypoxia inducible factor 1 alpha
, Hypoxia-inducible factor 1 alpha
, factor inhibiting HIF-1
, factor inhibiting HIF1
, hypoxia-inducible factor 1-alpha inhibitor
, hypoxia-inducible factor asparagine hydroxylase
, peptide-aspartate beta-dioxygenase
, hypoxia-inducible factor 1, alpha subunit inhibitor