HIF1AN antibody (AA 1-349)

Catalog No. ABIN6243664

Product Details anti-HIF1AN Antibody

Target: HIF1AN (Hypoxia Inducible Factor 1, alpha Subunit Inhibitor (HIF1AN))

Binding Specificity: AA 1-349

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This HIF1AN antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This HIF1AN antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 1-349 amino acids from human HIF1AN.

Clone: 931CT3-1-1

Isotype: IgG1 kappa

Application Details

Application Notes: IF: 1:25. WB: 1:4000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for HIF1AN

Target: HIF1AN (Hypoxia Inducible Factor 1, alpha Subunit Inhibitor (HIF1AN))

Alternative Name: HIF1AN (HIF1AN Products)

Synonyms: FIH1 antibody, 2310046M24Rik antibody, A830014H24Rik antibody, cb728 antibody, id:ibd5139 antibody, hypoxia inducible factor 1 alpha subunit inhibitor antibody, hypoxia-inducible factor 1, alpha subunit inhibitor antibody, hypoxia inducible factor 1, alpha subunit inhibitor antibody, hypoxia-inducible factor 1, alpha subunit inhibitor S homeolog antibody, HIF1AN antibody, Hif1an antibody, hif1an antibody, hif1an.S antibody

Background: Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300- interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation.

Molecular Weight: 40285

UniProt: Q9NWT6

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development