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The protein encoded by HIF3A is the alpha-3 subunit of one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). Additionally we are shipping HIF3A Proteins (4) and HIF3A Kits (2) and many more products for this protein.
Showing 10 out of 96 products:
Mouse (Murine) Polyclonal HIF3A Primary Antibody for EIA, IF - ABIN118015
Bruder, Naber, Grosch, Koslowski, Benesch, Budde, Hailer, Jacksch, Erbel, Sabin,: [New health care delivery model in cardiology -- Myocardial Infarction Network Essen] in Herz 2007
Show all 7 references for ABIN118015
Human Polyclonal HIF3A Primary Antibody for ICC, IF - ABIN250964
Forooghian, Razavi, Timms: Hypoxia-inducible factor expression in human RPE cells. in The British journal of ophthalmology 2007
Show all 6 references for ABIN250964
Human Polyclonal HIF3A Primary Antibody for IHC, WB - ABIN2778530
Lazrek, Goffard, Schanen, Karquel, Bocket, Lion, Devaux, Hedouin, Gosset, Hober: Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France. in Diagnostic microbiology and infectious disease 2006
Show all 2 references for ABIN2778530
Human Monoclonal HIF3A Primary Antibody for IHC, IHC (p) - ABIN4317485
Liu, Fang, Song, Jiang, He, Liu: Expression of hypoxia-inducible factor 3α in hepatocellular carcinoma and its association with other hypoxia-inducible factors. in Experimental and therapeutic medicine 2016
Mouse (Murine) Polyclonal HIF3A Primary Antibody for ELISA, WB - ABIN100475
Takeda, Ho, Takeda, Duan, Nagy, Fong: Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2. in Molecular and cellular biology 2006
Human Polyclonal HIF3A Primary Antibody for ICC, IF - ABIN315681
Huang, Kapere Ochieng, Kempen, Munck, Swagemakers, van Ijcken, Grosveld, Tibboel, Rottier: Hypoxia inducible factor 3α plays a critical role in alveolarization and distal epithelial cell differentiation during mouse lung development. in PLoS ONE 2013
Human Polyclonal HIF3A Primary Antibody for WB - ABIN151687
Jackson, Zhang, Hadley, Rabbani, Zhang, Marks, Vujaskovic: Temporal expression of hypoxia-regulated genes is associated with early changes in redox status in irradiated lung. in Free radical biology & medicine 2012
Report suggests that BV-2 microglial cells express HIF-3a under inflammatory conditions and that its activation differed from that of HIF-1a (show HIF1A Antibodies)
mRNA of HIF-2alpha (show EPAS1 Antibodies) and Ets-1 (show ETS1 Antibodies) were significantly increased by HIF-3alpha ablation. Both factors activate the VE-cadherin (show CDH5 Antibodies) gene, the transcriptional repression of these factors by HIF-3alpha is important for silencing the irrelevant expression of the VE-cadherin (show CDH5 Antibodies) gene.
our data indicated that Tnni2K175del mutation led to abnormally increased hif3a and decreased vegf in bone, which explain, at least in part, the small body size of Tnni2K175del mice
Anoxia preconditioning increases anti-ischemic neuronal resistance which to a certain extent correlates with the changes of HIF-1alpha (show HIF1A Antibodies) and HIF-3alpha expression.
alternative splicing and expression of IPAS is induced by hypoxia.
By generating mice with a targeted disruption of the NEPAS/HIF-3alpha locus, it was found that homozygous mutant mice, NEPAS/HIF-3alpha(-/-), were viable but displayed enlargement of the right ventricle and impaired lung remodeling.
Identity of third HIF alpha class member, HIF-3alpha. mRNA expression information by mouse MTN. Experimental proof of dimerization with ARNT/HIF-1beta (show ARNT Antibodies).
This provides a compelling model for how hypoxia-induced miR (show MLXIP Antibodies)-429 regulates the switch between HIF-1 (show HIF1A Antibodies) adaptive responses to HIF-3 survival responses by rapidly decreasing HIF1A (show HIF1A Antibodies) levels while simultaneously slowing the progression of HIF3A expression until the miR (show MLXIP Antibodies)-429 levels drop below normoxic levels.
The association between increased DNA methylation (show HELLS Antibodies) at HIF3A and increased adiposity is present in neonates.
HIF3A DNA Methylation Is Associated with Childhood Obesity and ALT
HIF3alpha has a transcriptional regulatory function, which negatively affects gene expression by competing with HIF1alpha (show HIF1A Antibodies) and HIF2alpha (show EPAS1 Antibodies) in binding to transcriptional elements in target genes during hypoxia. (Review)
A DNA methylation (show HELLS Antibodies) variant in HIF3A was associated with BMI changes through interactions with total or supplemental vitamin B2, vitamin B12 (show NDUFB3 Antibodies), and folate.
Here we provide evidence for the miRNA mediated regulation of HIF3a by hypoxia responsive miRNAs in STS (show STS Antibodies), which may help to tightly regulate and fine-tune the hypoxic response.
The Inhibitory Per/Arnt (show ARNT Antibodies)/Sim (show SIM2 Antibodies) (PAS (show PASK Antibodies)) domain protein (IPAS) is a splice variant of hypoxia-inducible factor (HIF)-3alpha, and possesses two entirely different functions. The results strongly suggest that IPAS is a nucleocytoplasmic shuttling protein.
the transcription of HIF-3alpha4 was silenced by the promoter DNA methylation (show HELLS Antibodies) in meningiomas, and inducible HIF-3alpha4 impaired angiogenesis, proliferation, and metabolism/oxidation in hypervascular meningiomas
HIF3A is regulated by hypoxia in the developing human lung.
Hypoxia upregulated transcription from all three alternative HIF-3alpha promoters. siRNA experiments showed that this induction is mediated specifically by HIF-1 (show HIF1A Antibodies) and not by HIF-2.
The protein encoded by this gene is the alpha-3 subunit of one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). The alpha-3 subunit lacks the transactivation domain found in factors containing either the alpha-1 or alpha-2 subunits. It is thought that factors containing the alpha-3 subunit are negative regulators of hypoxia-inducible gene expression. Multiple alternatively spliced transcript variants have been found for this gene.
hypoxia inducible factor 3, alpha subunit
, hypoxia-inducible factor 3 alpha subunit
, hypoxia-inducible factor 3-alpha
, hypoxia-inducible factor-3 alpha
, hypoxia-inducible factor 3-alpha-like
, basic-helix-loop-helix-PAS protein MOP7
, hypoxia inducible factor three alpha
, inhibitory PAS domain protein
, member of PAS protein 7
, neonatal and embryonic PAS
, HIF-3 alpha
, HIF3 alpha 1
, hypoxia inducible factor 3 alpha
, hypoxia inducible factor 3a
, hypoxia-inducible factor 3 alpha
, PAS domain-containing protein 7
, class E basic helix-loop-helix protein 17