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Iduronidase, alpha-L- Proteins (IDUA)

IDUA encodes an enzyme that hydrolyzes the terminal alpha-L-iduronic acid residues of two glycosaminoglycans, dermatan sulfate and heparan sulfate. Additionally we are shipping IDUA Antibodies (56) and IDUA Kits (16) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat IDUA IDUA 360904  
IDUA 3425 P35475
IDUA 15932  
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Top IDUA Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
Yeast Human His tag 50 μg Log in to see 31 to 36 Days
$341.00
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

IDUA Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,

Mouse (Murine)

More Proteins for Iduronidase, alpha-L- (IDUA) Interaction Partners

Zebrafish Iduronidase, alpha-L- (IDUA) interaction partners

  1. In the absence of Fgfrl1a, larvae fail to express the transcription factor glial cells missing 2 (gcm2 (show GCM2 Proteins)), a gene necessary for cartilage and gill filament formation, in the ectodermal lining of the branchial arches.

Human Iduronidase, alpha-L- (IDUA) interaction partners

  1. A new IDUA variant that alters the structure of the signal peptide associated with mucopolysaccharidosis type I is reported.

  2. Amino acid substitutions in alpha-L-iduronidase determine the severity of mucopolysaccharidosis type I.

  3. The alpha-L-iduronidase missense mutation causing L238Q substitution, when paired with a nonsense mutation, is associated with significant, late-onset brain disease.

  4. We conclude that this procedure for determining residual IDUA activity in fibroblasts of MPS I patients may be helpful to predict MPS I phenotype.

  5. The IDUA structures and biochemical analysis of the disease-relevant P533R mutation have enabled us to correlate the effects of mutations in IDUA to clinical phenotypes.

  6. Data show that alpha-l-iduronidase (hIDUA) enzyme activity was highly correlated with the N-glycan attached to N372.

  7. X-ray diffraction analysis of human alpha-L-iduronidase

  8. Transfer of a high level of human alpha-L-iduronidase gene into the central nervous system (CNS) of MPS I mutant mice susceptible to mucopolysaccharidosis (MPS) improves the outcome for MPS when a high level of CNS gene expression is achieved.

  9. A previously unreported IDUA splice site mutation (NG_008103.1:g.21632G>C; NM_000203.3:c.1727+3G>C) causing a Hurler phenotype in a patient heterozygous for the common p.Q70X (NG_008103.1:g.5862C>T) mutation.

  10. This paper, showed a heterogeneous pattern of mutations and polymorphisms in the IDUA gene among Tunisian patients.

Mouse (Murine) Iduronidase, alpha-L- (IDUA) interaction partners

  1. This study demonstrated that the distribuation of bis (show BAG3 Proteins)(monoacylglycero)phosphate in brain of mucopolysaccharidosis 1 (Hurler) mouse.

  2. Mucopolysaccharidosis type I, unique structure of accumulated heparan sulfate and increased N-sulfotransferase activity in mice lacking alpha-l-iduronidase.

  3. Studies show that mouse Idua-W392X mutation is analogous to the human IDUA-W402X mutation commonly found in MPS I-H patients.

  4. Data show that late-stage erythroid cells, transduced with a tissue-specific lentiviral vector, can deliver alpha-L-iduronidase continuously and can correct the disease phenotype in both viscera and CNS of MPS I mice.

  5. The results indicate that Idua(-/-) mice present deficits in long-term memory for aversive training and reduced exploratory behavior.

  6. IDUA(-/-) mice from adolescence to maturity, exhibited locomotor and anxiety-like compulsive behaviors, spatial learning and memory, visual recognition and short-term non-associative memory retention.

IDUA Protein Profile

Protein Summary

This gene encodes an enzyme that hydrolyzes the terminal alpha-L-iduronic acid residues of two glycosaminoglycans, dermatan sulfate and heparan sulfate. This hydrolysis is required for the lysosomal degradation of these glycosaminoglycans. Mutations in this gene that result in enzymatic deficiency lead to the autosomal recessive disease mucopolysaccharidosis type I (MPS I).

Gene names and symbols associated with Iduronidase, alpha-L- Proteins (IDUA)

  • iduronidase, alpha-L- (idua)
  • iduronidase, alpha-L- (IDUA)
  • fibroblast growth factor receptor-like 1a (fgfrl1a)
  • fibroblast growth factor receptor-like 1 (FGFRL1)
  • alpha-l-iduronidase (AaeL_AAEL004402)
  • alpha-L-iduronidase (LOC100231378)
  • alpha-L-iduronidase (Idua)
  • iduronidase, alpha-L- (Idua)
  • 6030426D08 protein
  • alpha-L-iduronidase protein
  • fgfrl1 protein
  • IDA protein
  • IDUA protein
  • MGC80842 protein
  • MPS1 protein
  • si:ch211-12e13.9 protein
  • zgc:64084 protein

Protein level used designations for Iduronidase, alpha-L- Proteins (IDUA)

iduronidase, alpha-L- , alpha-L-iduronidase , fibroblast growth factor receptor-like 1 , alpha-l-iduronidase

GENE ID SPECIES
446866 Xenopus laevis
511050 Bos taurus
567720 Danio rerio
100146682 Equus caballus
100560915 Anolis carolinensis
393347 Danio rerio
532327 Bos taurus
5564727 Aedes aegypti
100231378 Taeniopygia guttata
360904 Rattus norvegicus
100505382 Canis lupus familiaris
3425 Homo sapiens
15932 Mus musculus
427294 Gallus gallus
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