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The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Additionally we are shipping Immunoglobulin (CD79A) Binding Protein 1 Kits (8) and Immunoglobulin (CD79A) Binding Protein 1 Proteins (6) and many more products for this protein.
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Human Polyclonal IGBP1 Primary Antibody for IP, WB - ABIN151932
LeNoue-Newton, Watkins, Zou, Germane, McCorvey, Wadzinski, Spiller: The E3 ubiquitin ligase- and protein phosphatase 2A (PP2A)-binding domains of the Alpha4 protein are both required for Alpha4 to inhibit PP2A degradation. in The Journal of biological chemistry 2011
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Knockdown of Alpha4 preferentially impacts the expression of PP4c (show PPP4C Antibodies) and PP6c (show PPP6C Antibodies) compared to expression levels of PP2Ac (show PPP2CA Antibodies).
Data show that loss of epithelial membrane protein 2 (EMP2) is involved in sphingosylphosphorylcholine (SPC (show UCN3 Antibodies))-induced phosphorylation of keratin 8 (show KRT8 Antibodies) (K8) via ubiquitination of protein phosphatase 2 (PP2A (show PPP2R4 Antibodies)) through alpha4 phosphoprotein by caveolin-1 (cav-1 (show CAV1 Antibodies)).
MID1 (show MID1 Antibodies) catalyzes the ubiquitination of protein phosphatase 2A and mutations within its Bbox1 (show BBOX1 Antibodies) domain disrupt polyubiquitination of alpha4 but not of PP2Ac (show PPP2CA Antibodies) in X-linked Opitz syndrome.
alpha4 is an important regulatory molecule of apoptosis and Bcl-xL (show BCL2L1 Antibodies) phosphorylation induced by BCR (show BCR Antibodies) crosslinking.
the alpha4 N-terminus binding to endogenous PP2Ac (show PPP2CA Antibodies) and PABP (show PABPC1 Antibodies), and the C-terminus to EDD (show UBR5 Antibodies), is reported.
A potential important role of alpha4 in control of cell migration and/or invasion via the regulation of E-cadherin (show CDH1 Antibodies) expression in bladder urothelial carcinoma.
The structure of alpha45 reveals two distinct surfaces, one that can interact with a negatively charged surface, which is present on PP2A (show PPP2R4 Antibodies), and one that interacts with the Bbox1 (show BBOX1 Antibodies) domain of MID1 (show MID1 Antibodies).
both the C-terminal Mid1 (show MID1 Antibodies)-binding domain and the PP2Ac (show PPP2CA Antibodies)-binding determinants are required for Alpha4-mediated protection of PP2Ac (show PPP2CA Antibodies) from polyubiquitination and degradation.
IGBP-1 is expressed universally in advanced lung adenocarcinomas, and its overexpression is significantly related to outcome.
Data show that in addition to PP2Ac (show PPP2CA Antibodies), alpha4 interacts with EDD (show UBR5 Antibodies) and PABP (show PABPC1 Antibodies), suggesting its involvement in multiple steps in the mTOR (show FRAP1 Antibodies) pathway that leads to translation initiation and cell-cycle progression.
results show that alpha4, a noncatalytic subunit of protein phosphatase 2A, is required to repress apoptosis in murine cells
alpha4 expression differentially increased or decreased phosphorylation of endogenous phosphoproteins, consistent with opposing effects on PP2A (show PPP2R2B Antibodies) and PP6
Alpha4 (Igbp1) plays a required role in regulating the assembly and maintenance of adaptive PP2A (show PPP2R2B Antibodies) phosphatase complexes.
The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Binding of antigens to specific B-cell receptors results in a tyrosine phosphorylation reaction through the BCR complex and leads to multiple signal transduction pathways.
B cell signal transduction molecule alpha 4
, B-cell signal transduction molecule alpha 4
, CD79a-binding protein 1
, bA351K23.1 (immunoglobulin binding protein 1 (CD79A) )
, immunoglobulin-binding protein 1
, protein alpha-4
, protein phosphatase 2/4/6 regulatory subunit
, protein phosphatase 2A, regulatory subunit alpha-4
, renal carcinoma antigen NY-REN-16
, alpha4 phosphoprotein
, immunoglobulin binding protein 1
, alpha 4
, lymphocyte signal transduction molecule alpha 4
, phosphoprotein, component, 52 kDa
, immunoglobulin (CD79A) binding protein 1