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Immunoglobulin Associated alpha Proteins (IgA)

Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Additionally we are shipping Immunoglobulin Associated alpha Antibodies (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
IgA 12518 P11911
IgA    
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Top Immunoglobulin Associated alpha Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$777.70
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$844.80
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$952.01
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 19 Days
$1,014.95
Details

IgA Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human

More Proteins for Immunoglobulin Associated alpha (IgA) Interaction Partners

Mouse (Murine) Immunoglobulin Associated alpha (IgA) interaction partners

  1. BCR (show BCR Proteins) activation is accompanied by asymmetric conformational changes, possibly promoting the binding of Igalpha and Igbeta to differently localized signaling complexes

  2. CD79a (show CD79A Proteins) myeloid cells showed enhanced ability to promote primary tumor growth and metastasis.

  3. Data indicate that in the absence of DGKzeta (show DGKZ Proteins), the threshold for B cell antigen receptor (BCR (show BCR Proteins)) signaling, measured as activation of the Ras-extracellular signal-regulated kinase (ERK (show EPHB2 Proteins)) pathway, was markedly reduced in mature follicular B cells.

  4. Data show that the B cell antigen receptor (BCR (show BCR Proteins)) and Igalpha may be required for B cell survival because they function as adaptor proteins in a BAFFR (show TNFRSF13C Proteins) signaling pathway leading to activation of Syk (show SYK Proteins), indicating crosstalk between the two receptors.

  5. The mouse B cell-specific mb-1 (show PSMB5 Proteins) gene encodes an immunoreceptor tyrosine-based activation motif (ITAM) protein that may be evolutionarily conserved in diverse species by purifying selection.

  6. endocytosed BCR (show BCR Proteins) sequentially regulates MAPK (show MAPK1 Proteins) and Akt (show AKT1 Proteins) signaling pathways from intracellular compartments

  7. Arginine 198 in the tail of the Igalpha subunit of the BCR (show BCR Proteins) is methylated by the protein arginine methyltransferase 1 (show PRMT1 Proteins). Methylation negatively regulates the calcium and PI-3 (show PI3 Proteins) kinase pathways of the BCR (show BCR Proteins), promoting signals leading to B (show TDO2 Proteins) cell differentiation.

  8. The direct recruitment of BLNK (show BLNK Proteins) to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways

  9. IgA deficiency in lymphotoxin-deficient (LT(-/-)) mice could be fully reversed by reconstitution with LT-expressing bone marrow, despite the absence of both LNs and PPs.

  10. The VHDJH recombination process at the IgH locus and the survival of pro-B cells that carry these rearrangements do not depend on the expression of Ig-alpha molecules.

Immunoglobulin Associated alpha (IgA) Protein Profile

Protein Summary

Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src- family tyrosine kinases. Represses BCR signaling during development of immature B-cells.

Gene names and symbols associated with IgA

  • CD79A antigen (immunoglobulin-associated alpha) (Cd79a)
  • Ig-alpha protein
  • Iga protein
  • Igalpha protein
  • Ly-54 protein
  • Ly54 protein
  • mb-1 protein

Protein level used designations for IgA

B-cell antigen receptor complex-associated protein alpha chain , Ig alpha , MB-1 membrane glycoprotein , immunoglobulin-associated alpha , membrane-bound immunoglobulin-associated protein , surface IgM-associated protein

GENE ID SPECIES
12518 Mus musculus
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