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IP6K1 encodes a member of the inositol phosphokinase family. Additionally we are shipping IP6K1 Antibodies (60) and many more products for this protein.
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provides the first evidence for the involvement of IP6Ks in dynein function and proposes that inositol pyrophosphate-mediated pyrophosphorylation may act as a regulatory signal to enhance dynein-driven transport
IP6K1 is also involved in early cytoskeleton remodeling events during cancer progression.
IP6K1 is a novel CRL4 subunit that transduces UV signals to mediate disassembly of the CRL4-CSN complex, thereby regulating nucleotide excision repair and cell death.
we identified IP6Ks as novel nuclear and cytosolic InsP6- (and InsP5-) dephosphorylating enzymes whose activity is sensitively driven by a decrease in the cellular ATP/ADP ratio
FGF2 (show FGF2 Proteins)-signaling involves the inositol polyphosphate cascade, including inositol hexakisphosphate kinase (IP6K), and demonstrate that IP6K1,2 regulates Runx2 (show RUNX2 Proteins) and osteoblast gene expression.
IHPK1 gene is disrupted at the 3p21.31 breakpoint of t(3;9) in a family with type 2 diabetes mellitus
Results report the characterization of an inhibitor, N(2)-(m-(trifluoromethy)lbenzyl) N(6)-(p-nitrobenzyl)purine (TNP), selective for inositol hexakisphosphate kinases.
IP6K1 regulates energy metabolism via a mechanism that could potentially be targeted in obesity.
IP6K1 preferentially bound to the phospholipid phosphatidic acid, and this binding was required for IP6K1 nuclear localization and the regulation of inositol-3-phosphate synthase transcription.
present study demonstrates that IP6K1 physiologically regulates GSK3 kinases.
IP6K1 has a role in regulation of mammalian hemostasis via its control of platelet polyP levels
Mouse embryonic fibroblasts (MEFs) lacking IP6K1 exhibit impaired DNA damage repair via homologous recombination.
Defects in the mutants indicate important roles for IP6K1 and inositol pyrophosphates in several physiological functions
This gene encodes a member of the inositol phosphokinase family. The encoded protein may be responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Alternatively spliced transcript variants have been described.
inositol hexaphosphate kinase 1
, inositol hexakisphosphate kinase 1
, inositol hexakisphosphate kinase 6
, insP6 kinase 1
, ATP:1D-myo-inositol-hexakisphosphate phosphotransferase
, Pi uptake stimulator