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Inositol Polyphosphate Phosphatase-Like 1 Proteins (INPPL1)

The protein encoded by INPPL1 is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. Additionally we are shipping Inositol Polyphosphate Phosphatase-Like 1 Antibodies (73) and Inositol Polyphosphate Phosphatase-Like 1 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
INPPL1 3636 O15357
INPPL1 16332 Q6P549
Rat INPPL1 INPPL1 65038 Q9WVR3
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Top Inositol Polyphosphate Phosphatase-Like 1 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details

INPPL1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

Top referenced Inositol Polyphosphate Phosphatase-Like 1 Proteins

  1. Human INPPL1 Protein expressed in Wheat germ - ABIN1307967 : Zhou, Liu, Tan: Prognostic value of elevated SHIP2 expression in laryngeal squamous cell carcinoma. in Archives of medical research 2012 (PubMed)

More Proteins for Inositol Polyphosphate Phosphatase-Like 1 (INPPL1) Interaction Partners

Zebrafish Inositol Polyphosphate Phosphatase-Like 1 (INPPL1) interaction partners

Human Inositol Polyphosphate Phosphatase-Like 1 (INPPL1) interaction partners

  1. these findings suggest that SHIP2 is an important regulator of hepatic lipogenesis and lipoprotein secretion in insulin (show INS Proteins) resistance state.

  2. investigated the molecular link between SHIP2 expression and metabolic dyslipidemia using overexpression or suppression of SHIP2 gene in HepG2 cells

  3. Findings indicate that SHIP2 is a regulator of lymphatic function in humans and that inherited mutations in the INPPL1 gene may act in concert with HGF (show HGF Proteins), and likely MAP3K7 (show MAP3K7 Proteins), mutations to exacerbate lymphatic phenotypes.

  4. SHIP2 inhibition was accompanied by an increased Akt (show AKT1 Proteins) and FOXO-1 (show FOXO1 Proteins) phosphorylation, whereas overexpression of the wild-type SHIP2 gene had the opposite effects

  5. In conclusion, SHIP2 plays a key role in breast cancer stem cells of ER-negative breast cancers

  6. Kaplan-Meier method and Cox (show COX8A Proteins) multifactor analysis suggested that high SHIP2 protein level and positive distant metastasis were critically associated with the unfavorable survival of coloretal cancer patients.

  7. results indicated genotype and allele frequency of SHIP2(+1893CC/AA) locus in Type 2 diabetes mellitus (T2DM) Han Chinese patients was significantly different from healthy controls; G allele (+2945A/G) seemed to increase susceptibility to hypertension for T2DM patients

  8. The crystal structures of human SHIP2 in complex with phosphoinositide substrate analogs revealed a membrane interaction patch likely to assist in sequestering substrates from the lipid bilayer.

  9. Association with SHIP2 and aging might depend on its effect on the insulin (show INS Proteins)/IGF-1 (show IGF1 Proteins) pathway.

  10. SHIP2 localization in intact cells is dependent on phosphorylation mechanisms on both Ser (show SIGLEC1 Proteins)/Thr (show TRH Proteins) and Tyr (show TYR Proteins) residues.

Mouse (Murine) Inositol Polyphosphate Phosphatase-Like 1 (INPPL1) interaction partners

  1. These findings suggest that palmitate contributes to SHIP2 overexpression in skeletal muscle via the mechanisms involving the activation of ceramide-JNK (show MAPK8 Proteins) and NF-kappaB (show NFKB1 Proteins) pathways.

  2. results suggest that SHIP2 contributes to the regulation of food intake mainly via the attenuation of insulin (show INS Proteins) signalling in the hypothalamus of mice

  3. The catalytically-inactive Ship2 mutant protein in a context of reduced PtdIns(4,5)P2 3-kinase activity.

  4. Regulation of insulin signaling and glucose transporter 4 (GLUT4) exocytosis by phosphatidylinositol 3,4,5-trisphosphate (PIP3) phosphatase, skeletal muscle, and kidney enriched inositol polyphosphate phosphatase (SKIP).

  5. These results suggest that SHIP2 is a potent negative regulator of insulin (show INS Proteins)/IGF-I (show IGF1 Proteins) actions in the brain, and excess amounts of SHIP2 may be related, at least in part, to brain dysfunction in insulin (show INS Proteins) resistance with type 2 diabetes.

  6. The SHIP2 is a negative regulator of insulin (show INS Proteins) signaling, our findings suggest the importance of the phosphoinositide metabolism at endocytic clathrin-coated pits in the regulation of insulin (show INS Proteins) signal output.

  7. Association with the insulin (show INS Proteins) resistance of diabetic db/db (show LEPR Proteins) mice.

  8. The role of SHIP2 in controlling phosphatidylinositol 3,4,5-trisphosphate levels in platelets.

  9. SH2-containing inositol phosphatase 2 predominantly regulates Akt2 (show AKT2 Proteins), and not Akt1 (show AKT1 Proteins), phosphorylation at the plasma membrane in response to insulin (show INS Proteins) in adipocytes

  10. SHIP2 plays an important role in the negative regulation of insulin (show INS Proteins) signaling for protein synthesis and the impact of SHIP2 is altered, dependent on the acute or chronic exposure of excess concentrations of amino acids in culture.

Pig (Porcine) Inositol Polyphosphate Phosphatase-Like 1 (INPPL1) interaction partners

  1. we suggest that SHIP2 might play a role in the regulation of skeletal muscle development in pigs

Inositol Polyphosphate Phosphatase-Like 1 (INPPL1) Protein Profile

Protein Summary

The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer.

Gene names and symbols associated with INPPL1

  • inositol polyphosphate phosphatase-like 1b (inppl1b)
  • inositol polyphosphate phosphatase-like 1 (INPPL1)
  • inositol polyphosphate phosphatase-like 1 (LOC100339369)
  • phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1-like (LOC100180571)
  • inositol polyphosphate phosphatase-like 1 (Inppl1)
  • 51C protein
  • INPPL1 protein
  • OPSMD protein
  • Ship2 protein
  • si:bz46j2.7 protein
  • si:rp71-46j2.7 protein

Protein level used designations for INPPL1

SH2-domain-containing inositol 5-phosphatase 2b , inositol polyphosphate phosphatase-like 1 , ship2b , phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2-like , 51C protein , INPPL-1 , SH2 domain-containing inositol 5'-phosphatase 2 , SH2 domain-containing inositol-5'-phosphatase 2 , SHIP-2 , phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 , phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 , protein 51C , SH2 domain-containing inositol phosphatase 2 , ablSH3-binding protein , inositol polyphosphate phosphatase-like protein 1 , SH2-containing inositol phosphatase 2

GENE ID SPECIES
368433 Danio rerio
428692 Gallus gallus
451403 Pan troglodytes
100339369 Oryctolagus cuniculus
100482460 Ailuropoda melanoleuca
100180571 Ciona intestinalis
100596562 Nomascus leucogenys
3636 Homo sapiens
16332 Mus musculus
65038 Rattus norvegicus
485209 Canis lupus familiaris
783833 Bos taurus
100462718 Sus scrofa
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