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anti-Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D) Antibodies

INPP5D is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Additionally we are shipping Inositol Polyphosphate-5-Phosphatase, 145kDa Kits (9) and Inositol Polyphosphate-5-Phosphatase, 145kDa Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
INPP5D 16331 Q9ES52
INPP5D 54259 P97573
INPP5D 3635 Q92835
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Top anti-Inositol Polyphosphate-5-Phosphatase, 145kDa Antibodies at antibodies-online.com

Showing 10 out of 106 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB Western blot analysis of INPP5D (arrow) using rabbit polyclonal INPP5D Antibody (Center) (ABIN389359). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the INPP5D gene (Lane 2) (Origene Technologies). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from HepG2 cells treated with TNF 200NG/ML 30', using SHIP1 (Phospho-Tyr1021) Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Mouse Un-conjugated EIA, WB 0.1 mg Log in to see 6 to 8 Days
$286.00
Details
Mouse Mouse Un-conjugated IF, WB Western blot analysis of SHIP-1 on rat spleen lysate. Lane 1: 1:250, lane 3: 1:500, lane 3: 1:1000 dilution of SHIP-1. Immunofluorescence staining of ES2 cells. 50 μg Log in to see 5 to 6 Days
$205.42
Details
Human Mouse Un-conjugated FACS, WB Western Blotting analysis (reducing conditions) of human SHIP-1 in whole cell lysate of THP-1 human acute monocytic leukemia cell line. Lane 1: immunostaining with Isotype mouse IgG1 control (PPV-04; 11-458-C100) Lane 2,3: immunostaining with anti-human SHIP-1 (SHIP-01 0.1 mg Log in to see 4 to 5 Days
$254.10
Details
Human Rabbit Un-conjugated IHC (p) 7 mL Log in to see 21 to 31 Days
$226.00
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-INPP5D AntibodyTitration: 1.0 µg/mL  Positive Control: THP-1 Whole Cell 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from HuvEc cells, using SHIP1 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Mouse PE FACS 100 μg Log in to see 10 to 12 Days
$353.29
Details

INPP5D Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Inositol Polyphosphate-5-Phosphatase, 145kDa Antibodies

  1. Human Monoclonal INPP5D Primary Antibody for FACS - ABIN2662843 : Banh, Miah, Kerr, Brossay: Mouse natural killer cell development and maturation are differentially regulated by SHIP-1. in Blood 2012 (PubMed)
    Show all 5 references for ABIN2662843

  2. Human Monoclonal INPP5D Primary Antibody for EIA, WB - ABIN238500 : Xing, Hamaguchi: Effects of SHIP-1 on MMP2 secretion and invasion of SR3Y1 cells. in Journal of genetics and genomics = Yi chuan xue bao 2007 (PubMed)
    Show all 4 references for ABIN238500

  3. Human Monoclonal INPP5D Primary Antibody for FACS, WB - ABIN302082 : Harris, Parry, Westwick, Ward: Phosphoinositide lipid phosphatases: natural regulators of phosphoinositide 3-kinase signaling in T lymphocytes. in The Journal of biological chemistry 2008 (PubMed)
    Show all 3 references for ABIN302082

  4. Mouse (Murine) Monoclonal INPP5D Primary Antibody for IF, WB - ABIN968479 : Lioubin, Algate, Tsai, Carlberg, Aebersold, Rohrschneider: p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity. in Genes & development 1996 (PubMed)
    Show all 3 references for ABIN968479

  5. Human Polyclonal INPP5D Primary Antibody for EIA, WB - ABIN358021 : Gilby, Goodeve, Winship, Valk, Delwel, Reilly: Gene structure, expression profiling and mutation analysis of the tumour suppressor SHIP1 in Caucasian acute myeloid leukaemia. in Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2007 (PubMed)
    Show all 3 references for ABIN358021

  6. Human Polyclonal INPP5D Primary Antibody for ELISA, WB - ABIN1531473 : Ware, Rosten, Damen, Liu, Humphries, Krystal: Cloning and characterization of human SHIP, the 145-kD inositol 5-phosphatase that associates with SHC after cytokine stimulation. in Blood 1996 (PubMed)

More Antibodies against Inositol Polyphosphate-5-Phosphatase, 145kDa Interaction Partners

Zebrafish Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D) interaction partners

Mouse (Murine) Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D) interaction partners

  1. Our results describe a critical role for SHIP-1 in regulating the ability of dendritic cells to efficiently prime Th2-type responses.

  2. Findings indicate a role for inositol-polyphosphate 5-phosphatase SHIP-1 coupling to DC-type lectin receptor ectin-1 hemITAM in the selective control of downstream responses.

  3. miR (show MLXIP Antibodies)-155 regulates the delicate balance between PAK1 (show PAK1 Antibodies)-mediated proliferation and apoptosis in T cells impacting lymphoid organ size and function.

  4. miR (show MLXIP Antibodies)-155 regulation of SHIP represents a unique axis that regulates dendritic cells function in vivo.

  5. SHIP1 and Csk (show CSK Antibodies) are part of the PSTPIP2 (show PSTPIP2 Antibodies)-dependent inhibitory network that prevents the development of autoinflammatory disease.

  6. intracellular signaling by SHIP1 in mesenchymal stem cells is critical for hematopoiesis and lineage commitment during aging.

  7. Data show that 5'-inositol phosphatase SHIP1 deficiency extrinsically affects invariant NK (iNKT) cell proliferation.

  8. Selective deletion of Ship1 in T cells or dendritic cells impairs the formation of an adaptive TH2 response and protects animals from house dust mite-induced allergic airway inflammation.

  9. SHIP1 regulates mesenchymal stem cell numbers and their osteolineage commitment by limiting induction of the PI3K/Akt (show AKT1 Antibodies)/beta-catenin (show CTNNB1 Antibodies) pathways

  10. by promoting survival of protective T cells, thereby preventing an inflammatory myeloid response, SHIP1 maintains an appropriate balance of innate immune function at mucosal surfaces necessary for immune homeostasis.

Human Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D) interaction partners

  1. SHIP levels and activity are lower in intestinal tissues and peripheral blood samples from patients with Crohn's disease, resulting in induction of Il1-beta (show IL1B Antibodies).

  2. Underexpression of SHIP1 is associated with drug resistance in acute myeloid leukemia (show BCL11A Antibodies).

  3. ectopically expressed SHIP1 accumulates in nucleolar cavities and colocalizes with the tumor suppressor protein p53 (show TP53 Antibodies).

  4. Results show that expression of SHIP1 protein is targeted by miR (show MLXIP Antibodies)-155 in acute myeloid leukemia (show BCL11A Antibodies) (AML (show RUNX1 Antibodies)) suggesting it as an onco-miR (show MLXIP Antibodies). The miR (show MLXIP Antibodies)-155/SHIP1/PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) signaling pathway could play an important role in the pathogenesis of AML (show RUNX1 Antibodies).

  5. Overexpression of miR (show MLXIP Antibodies)-155 in the gouty synovial fluid mononuclear cells leads to suppress SHIP-1 levels and enhance proinflammatory cytokines.

  6. SLAMF7 (show SLAMF7 Antibodies)-triggered inhibition is mediated by a mechanism involving Src (show SRC Antibodies) kinases, CD45 (show PTPRC Antibodies), and SHIP-1 that is defective in MM cells

  7. The discovery and replication studies presented here show SHIP-1 to be a risk marker for acute ischemic stroke in the Chinese population, which appears to be a novel finding.

  8. High ship1 expression is associated with chronic lymphocytic leukemia.

  9. Tks5 (show SH3PXD2A Antibodies) is needed for breast carcinoma cell invadopodium precursor stabilization, where the phox homology (PX) domain of Tks5 (show SH3PXD2A Antibodies) interacts with PI(3,4)P2. SHIP2 (show INPPL1 Antibodies) arrival at the invadopodium precursor coincides with the onset of PI(3,4)P2 accumulation.

  10. Based on these observations, authors conclude that miR (show MLXIP Antibodies)-155 modulates the neuroinflammatory response during Japanese encephalitis virus infection via negative regulation of SHIP1 expression.

Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D) Antigen Profile

Protein Summary

This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene names and symbols associated with INPP5D

  • inositol polyphosphate-5-phosphatase, 145kDa (INPP5D) antibody
  • inositol polyphosphate-5-phosphatase, 145kDa (inpp5d) antibody
  • inositol polyphosphate 5-phosphatase (EHI_159880) antibody
  • inositol polyphosphate 5-phosphatase (EHI_153490) antibody
  • phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 (inpp5d) antibody
  • Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 (ship1) antibody
  • inositol polyphosphate-5-phosphatase D (Inpp5d) antibody
  • 13.t00027 antibody
  • 256.t00004 antibody
  • AI323613 antibody
  • hp51CN antibody
  • INPP5D antibody
  • s-SHIP antibody
  • SHIP antibody
  • SHIP-1 antibody
  • SHIP1 antibody
  • SIP-145 antibody

Protein level used designations for INPP5D

inositol polyphosphate-5-phosphatase, 145kDa , SH2 containing inositol phosphatase , phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 , phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1-like , SH2 domain-containing inositol 5'-phosphatase 1 , SH2 domain-containing inositol phosphatase 1 , SH2 domain-containing inositol-5'-phosphatase 1 , SHIP-1 , phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 , Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 , SH2 containing inositol phosphotase , SH2-containing inositol phosphatase SHIP , SIP-145 , Src homology 2 domain-containing inositol-5-phosphatase , inositol polyphosphate-5-phosphatase of 145 kDa , inositol polyphosphate-5-phosphatase, 145 kDa , p150Ship , Inositol polyphosphate-5-phosphatase 145 kDa , Inositol polyphosphate-5-phosphatase, 145 kDa , signaling inositol polyphosphate 5 phosphatase SIP-145

GENE ID SPECIES
424745 Gallus gallus
470683 Pan troglodytes
507329 Bos taurus
100021361 Monodelphis domestica
100400043 Callithrix jacchus
100446045 Pongo abelii
100464150 Ailuropoda melanoleuca
559103 Danio rerio
3404260 Entamoeba histolytica HM-1:IMSS
3410671 Entamoeba histolytica HM-1:IMSS
100064896 Equus caballus
100526019 Sus scrofa
100561031 Anolis carolinensis
399051 Xenopus laevis
100380693 Salmo salar
16331 Mus musculus
54259 Rattus norvegicus
3635 Homo sapiens
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