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Inositol Polyphosphate-5-Phosphatase, 72 KDa Proteins (INPP5E)

The protein encoded by INPP5E is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. Additionally we are shipping INPP5E Antibodies (17) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
INPP5E 64436 Q9JII1
INPP5E 114089  
INPP5E 56623 Q9NRR6
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Top INPP5E Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,875.67
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

INPP5E Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Rat (Rattus)

Human , ,
,

More Proteins for Inositol Polyphosphate-5-Phosphatase, 72 KDa (INPP5E) Interaction Partners

Mouse (Murine) Inositol Polyphosphate-5-Phosphatase, 72 KDa (INPP5E) interaction partners

  1. the affinity to PDE6delta and the release by Arl2 (show ARL2 Proteins)/3 in addition to a retention signal are the determinants for cargo sorting and enrichment at its destination.

  2. PIPKIgamma and INPP5E localize to the centrosome and coordinate the initiation of ciliogenesis.

  3. Inpp5e, through functional interactions with Rab20 (show RAB20 Proteins) on the phagosome, activates Rab5 (show RAB5A Proteins), which, in turn, increases PtdIns3P and delays phagosome acidification.

  4. Inpp5e and SHIP1 (show INPP5D Proteins) exhibit specificity in regulating FcgammaR- versus CR3 (show ITGAM Proteins)-stimulated phagocytosis by controlling the amplitude and duration of PtdIns(3,4,5)P(3) at the phagocytic cup.

  5. Inpp5e mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in the mouse.

Human Inositol Polyphosphate-5-Phosphatase, 72 KDa (INPP5E) interaction partners

  1. MKS1 (show MKS1 Proteins) functions in the transition zone at the base of the cilium to regulate ciliary INPP5E content.

  2. PIPKIgamma and INPP5E localize to the centrosome and coordinate the initiation of ciliogenesis.

  3. These findings establish the first direct link between AURKA (show AURKA Proteins) and phosphoinositide signaling and suggest that the function of INPP5E in cilia is at least partly mediated by its interactions with AURKA (show AURKA Proteins)

  4. Proteomic analysis identified INPP5E, whose mutations also lead to Joubert syndrome as novel prenyl-dependent cargo of PDE6D (show PDE6D Proteins). Mutant PDE6D (show PDE6D Proteins) shows reduced binding to INPP5E, which fails to localize to primary cilia in patient fibroblasts and tissues.

  5. Identification of 12 different INPP5E mutations in patients with Joubert syndrome with an overall 2.7% mutation frequency.

  6. findings indicate that ARL13B (show ARL13B Proteins), INPP5E, PDE6D (show PDE6D Proteins), and CEP164 form a distinct functional network that is involved in JBTS and NPHP but independent of the ones previously defined by NPHP and MKS (show MKS1 Proteins) proteins

  7. INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in humans.

  8. Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies.

INPP5E Protein Profile

Protein Summary

The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome\; a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly.

Gene names and symbols associated with INPP5E

  • inositol polyphosphate-5-phosphatase E (Inpp5e)
  • inositol polyphosphate-5-phosphatase, 72 kDa (INPP5E)
  • 72kDa protein
  • 1200002L24Rik protein
  • CORS1 protein
  • CPD4 protein
  • JBTS1 protein
  • mKIAA0123 protein
  • MORMS protein
  • PMPCA protein
  • PPI5PIV protein

Protein level used designations for INPP5E

72 kDa inositol polyphosphate 5-phosphatase , inositol polyphosphate-5-phosphatase, 72 kDa , phosphatidylinositol 4,5-bisphosphate 5-phosphatase , phosphatidylinositol polyphosphate 5-phosphatase type IV , phosphatidylinositol-4,5-bisphosphate 5-phosphatase , 5-phosphatase that induces arborization , inositol polyphosphate 5-phosphatase , pharbin , phosphatidylinositol (4,5) bisphosphate 5-phosphatase , inositol polyphosphate-5-phosphatase E , peptidase (mitochondrial processing) alpha

GENE ID SPECIES
64436 Mus musculus
114089 Rattus norvegicus
56623 Homo sapiens
748603 Pan troglodytes
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