Inositol Polyphosphate-5-Phosphatase, 72 KDa Proteins (INPP5E)

The protein encoded by INPP5E is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. Additionally we are shipping INPP5E Antibodies (19) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
INPP5E 64436 Q9JII1
INPP5E 114089  
INPP5E 56623 Q9NRR6
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Top INPP5E Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
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Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,875.67
Details

INPP5E Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Rat (Rattus)

Human , ,
, ,

More Proteins for Inositol Polyphosphate-5-Phosphatase, 72 KDa (INPP5E) Interaction Partners

Mouse (Murine) Inositol Polyphosphate-5-Phosphatase, 72 KDa (INPP5E) interaction partners

  1. we identify Inpp5e as an essential inhibitor of the PI3K/Akt (show AKT1 Proteins)/mTORC1 signaling axis in renal epithelial cells, and demonstrate a critical role for Inpp5e-dependent mTORC1 regulation in Polycystic kidney disease (PKD (show PRKD1 Proteins)) suppression

  2. INPP5E localizes to centrosomes, chromosomes, and kinetochores in early mitosis and shuttles to the midzone spindle at mitotic exit.

  3. INPP5E is an essential point of convergence between Hedgehog (show SHH Proteins) and phosphoinositide signaling at cilia that maintains transition zone function and Hedgehog (show SHH Proteins)-dependent embryonic development.

  4. the affinity to PDE6delta and the release by Arl2 (show ARL2 Proteins)/3 in addition to a retention signal are the determinants for cargo sorting and enrichment at its destination.

  5. PIPKIgamma and INPP5E localize to the centrosome and coordinate the initiation of ciliogenesis.

  6. Inpp5e, through functional interactions with Rab20 (show RAB20 Proteins) on the phagosome, activates Rab5 (show RAB5A Proteins), which, in turn, increases PtdIns3P and delays phagosome acidification.

  7. Inpp5e and SHIP1 (show INPP5D Proteins) exhibit specificity in regulating FcgammaR- versus CR3 (show ITGAM Proteins)-stimulated phagocytosis by controlling the amplitude and duration of PtdIns(3,4,5)P(3) at the phagocytic cup.

  8. Inpp5e mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in the mouse.

Human Inositol Polyphosphate-5-Phosphatase, 72 KDa (INPP5E) interaction partners

  1. we identify Inpp5e as an essential inhibitor of the PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins)/mTORC1 signaling axis in renal epithelial cells, and demonstrate a critical role for Inpp5e-dependent mTORC1 regulation in Polycystic kidney disease (PKD (show PRKD1 Proteins)) suppression

  2. ARL13B (show ARL13B Proteins) regulates IFT-A-mediated retrograde protein trafficking within cilia through its interaction with INPP5E.

  3. In neuronal cells, INPP5E knockdown strongly inhibited autophagy by impairing the autophagosome-lysosome fusion step.

  4. INPP5E localizes to centrosomes, chromosomes, and kinetochores in early mitosis and shuttles to the midzone spindle at mitotic exit.

  5. INPP5E is an essential point of convergence between Hedgehog (show SHH Proteins) and phosphoinositide signaling at cilia that maintains transition zone function and Hedgehog (show SHH Proteins)-dependent embryonic development.

  6. MKS1 (show MKS1 Proteins) functions in the transition zone at the base of the cilium to regulate ciliary INPP5E content.

  7. PIPKIgamma and INPP5E localize to the centrosome and coordinate the initiation of ciliogenesis.

  8. These findings establish the first direct link between AURKA (show AURKA Proteins) and phosphoinositide signaling and suggest that the function of INPP5E in cilia is at least partly mediated by its interactions with AURKA (show AURKA Proteins)

  9. Proteomic analysis identified INPP5E, whose mutations also lead to Joubert syndrome as novel prenyl-dependent cargo of PDE6D (show PDE6D Proteins). Mutant PDE6D (show PDE6D Proteins) shows reduced binding to INPP5E, which fails to localize to primary cilia in patient fibroblasts and tissues.

  10. Identification of 12 different INPP5E mutations in patients with Joubert syndrome with an overall 2.7% mutation frequency.

INPP5E Protein Profile

Protein Summary

The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome\; a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly.

Gene names and symbols associated with INPP5E

  • inositol polyphosphate-5-phosphatase E (Inpp5e)
  • inositol polyphosphate-5-phosphatase, 72 kDa (INPP5E)
  • 72kDa protein
  • 1200002L24Rik protein
  • CORS1 protein
  • CPD4 protein
  • JBTS1 protein
  • mKIAA0123 protein
  • MORMS protein
  • PMPCA protein
  • PPI5PIV protein

Protein level used designations for INPP5E

72 kDa inositol polyphosphate 5-phosphatase , inositol polyphosphate-5-phosphatase, 72 kDa , phosphatidylinositol 4,5-bisphosphate 5-phosphatase , phosphatidylinositol polyphosphate 5-phosphatase type IV , phosphatidylinositol-4,5-bisphosphate 5-phosphatase , 5-phosphatase that induces arborization , inositol polyphosphate 5-phosphatase , pharbin , phosphatidylinositol (4,5) bisphosphate 5-phosphatase , inositol polyphosphate-5-phosphatase E , peptidase (mitochondrial processing) alpha

GENE ID SPECIES
64436 Mus musculus
114089 Rattus norvegicus
56623 Homo sapiens
748603 Pan troglodytes
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