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Inositol-Tetrakisphosphate 1-Kinase Proteins (ITPK1)

Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Additionally we are shipping ITPK1 Antibodies (71) and ITPK1 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ITPK1 683482 P40936
ITPK1 3705 Q13572
Rat ITPK1 ITPK1 500709  
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Top ITPK1 Proteins at antibodies-online.com

Showing 10 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$407.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast REACT_Entamoeba histolytica His tag   1 mg Log in to see 56 to 66 Days
$2,856.33
Details
Yeast Zebrafish His tag   1 mg Log in to see 56 to 66 Days
$3,094.67
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$3,129.50
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,166.17
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$498.21
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

ITPK1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

Top referenced ITPK1 Proteins

  1. Human ITPK1 Protein expressed in Escherichia coli (E. coli) - ABIN1098354 : Chamberlain, Qian, Stiles, Cho, Jones, Lesley, Grabau, Shears, Spraggon: Integration of inositol phosphate signaling pathways via human ITPK1. in The Journal of biological chemistry 2007 (PubMed)
    Show all 2 references for ABIN1098354

More Proteins for Inositol-Tetrakisphosphate 1-Kinase (ITPK1) Interaction Partners

Mouse (Murine) Inositol-Tetrakisphosphate 1-Kinase (ITPK1) interaction partners

  1. Data suggest that relative deficiency of one or more inositol phosphates accounts for neural tube defects in inositol 1,3,4-trisphosphate 5/6-kinase knockout mice.

  2. Apical localization of Itpk1 enhances its ability to be a modifier gene product in a murine tracheal cell model of cystic fibrosis (show S100A8 Proteins).

Human Inositol-Tetrakisphosphate 1-Kinase (ITPK1) interaction partners

  1. The results suggested that the maternal rs3783903 of ITPK1 might be associated with spina bifida, and the allele G of rs3783903 might affect the binding of AP-1 (show FOSB Proteins) and the decrease of maternal plasma inositol hexakisphosphate concentration.

  2. Activation of PLC (show HSPG2 Proteins) by an endogenous cytokine (GBP (show HADHA Proteins)) in Drosophila S3 cells and its application as a model for studying inositol phosphate signalling through ITPK1.

  3. HEK293 cells stably expressing acetylated ITPK1 had reduced levels of the higher phosphorylated forms of inositol, compared with the levels seen in cells expressing unacetylated ITPK1

  4. 5/6-kinase modifies TNFalpha (show TNF Proteins)-induced apoptosis by interfering with the activation of TNF-R1 (show TNFRSF1A Proteins)-associated death domain

  5. analysis of inositol phosphate signaling pathway integration via human ITPK1

ITPK1 Protein Profile

Protein Summary

Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain (By similarity). Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway.

Gene names and symbols associated with ITPK1

  • indolethylamine N-methyltransferase (Inmt)
  • inositol 1,3,4-triphosphate 5/6 kinase (itpk1)
  • inositol 1,3,4-triphosphate 5/6 kinase (Itpk1)
  • inositol-tetrakisphosphate 1-kinase (itpk1)
  • inositol-tetrakisphosphate 1-kinase (ITPK1)
  • inositol-tetrakisphosphate 1-kinase (Itpk1)
  • BC031182 protein
  • ITRPK1 protein
  • Temt protein
  • wu:fj15d08 protein
  • zgc:56075 protein

Protein level used designations for ITPK1

amine N-methyltransferase , aromatic alkylamine N-methyltransferase , arylamine N-methyltransferase , indolamine N-methyltransferase , nicotine N-methyltransferase , thioether S-methyltransferase , inositol 1,3,4-trisphosphate 5/6-kinase , inositol-tetrakisphosphate 1-kinase , inositol-triphosphate 5/6-kinase , ins(1,3,4)P(3) 5/6-kinase , inositol 1,3,4-triphosphate 5/6 kinase , inositol 1,3,4-trisphosphate 5/6 kinase

GENE ID SPECIES
683482 Mus musculus
406290 Danio rerio
217837 Mus musculus
379828 Xenopus laevis
3705 Homo sapiens
100152339 Sus scrofa
518488 Bos taurus
500709 Rattus norvegicus
423421 Gallus gallus
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