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Integrin-Linked Kinase Proteins (ILK)

Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Additionally we are shipping Integrin-Linked Kinase Antibodies (227) and Integrin-Linked Kinase Kits (27) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ILK 16202 O55222
ILK 3611 Q13418
ILK 170922 Q99J82
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Top Integrin-Linked Kinase Proteins at antibodies-online.com

Showing 10 out of 25 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Guinea Pig His tag   1 mg Log in to see 56 to 66 Days
$3,265.17
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,268.83
Details
Yeast Pongo abelii His tag   1 mg Log in to see 56 to 66 Days
$3,268.83
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,268.83
Details
HOST_Human Human His tag 10 μg Log in to see 6 to 11 Days
$355.71
Details
HOST_Escherichia coli (E. coli) Please inquire Un-conjugated   10 μg Log in to see 5 to 6 Days
$169.03
Details

ILK Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,
Rat (Rattus) ,

More Proteins for Integrin-Linked Kinase (ILK) Interaction Partners

Fruit Fly (Drosophila melanogaster) Integrin-Linked Kinase (ILK) interaction partners

  1. Targeted knockdown of the integrin focal adhesion complex components beta-integrin, PINCH (show LIMS1 Proteins), and integrin-linked kinase caused formation of multinucleate epidermal cells within the Drosophila larval epidermis.

  2. PINCH (show LIMS1 Proteins) and ILK have an independent capacity to localize at muscle attachment sites in vivo.

  3. ILK functions as an essential hub in the assembly of its partner proteins at sites of integrin adhesion.

Xenopus laevis Integrin-Linked Kinase (ILK) interaction partners

Mouse (Murine) Integrin-Linked Kinase (ILK) interaction partners

  1. Work provides a new tool for studying mouse oligodendrocyte precursor cell migration and highlights the role of integrin-linked kinase in its regulation on extracellular matrix proteins relevant to multiple sclerosis.

  2. We conclude that ILK negatively and independently of PI3K regulated MEF2C (show MEF2C Proteins) phosphorylation activity and MCK (show CKM Proteins) mRNA expression in C2C12 cells

  3. high extracellular concentration of phosphate induced senescence in cultured smooth muscle through the activation of IGF-1 (show IGF1 Proteins) receptor and ILK overexpression

  4. This study demonstrates a role for ILK in regulating laminin2-mediated adhesion and Ln-2-independent growth cone size/activity in oligodendrocyte

  5. ILK is indispensable for Brain-derived neurotrophic factor-mediated hippocampal neurogenesis and memory enhancement upon Environment enrichment stimuli via regulating glycogen synthase kinase-3beta activity.

  6. ELMO2 (show ELMO2 Proteins)-RhoG-ILK complex has a key role in integrin-independent stabilization of the microtubule network in differentiated keratinocytes.

  7. ILK is a key regulator of the bulge extracellular matrix microenvironment, thereby governing the activation and maintenance of hair follicle stem cells.

  8. CTGF (show CTGF Proteins) overexpression induces epithelial to mesenchymal transition in mouse primary AT II cells, which is mediated by ILK

  9. These data demonstrate that ILK is a linker between Integrin receptors and the Dynactin (show DCTN1 Proteins) complex to regulate mitotic spindle orientation.

  10. These observations demonstrate an important role for beta1-integrin/ILK signaling in regulating astrogliosis from ESCs (show NR2E3 Proteins) and suggest ILK as a potential target for limiting glial scar formation after nervous system injury.

Zebrafish Integrin-Linked Kinase (ILK) interaction partners

  1. Heart failure in recessive embryonic lethal zebrafish mutant main squeeze (msq) mutants is due to a mutation in the integrin-linked kinase (ilk) gene.

  2. The lost-contact mutant on chromosome 10 encodes a nonsense mutation (Y319X) associated with defective cardiomyocytes & endothelial cells that leads to severe myocardial dysfunction. There is epistatic regulation between laminin-alpha4, integrin, & Ilk.

  3. Data show that integrin-linked kinase is an essential component downstream of laminin and integrin alpha7, providing strengthening of skeletal muscle fibre adhesion with the extracellular matrix.

Human Integrin-Linked Kinase (ILK) interaction partners

  1. Twist-ITGB1 (show ITGB1 Proteins)-FAK (show PTK2 Proteins)/ILK pathway and their downstream signaling network dictate the Twist-induced EMT (show ITK Proteins) process in human mammary epithelial cells and breast cancer cells

  2. Results indicated that ILK is imperative in the development and progression of oral squamous cell carcinoma.

  3. Periostin (show POSTN Proteins) enhanced ensometrial stromal cell migration, invasion, and adhesion due to the ILK1/Akt (show AKT1 Proteins) signal pathway.

  4. high extracellular concentration of phosphate induced senescence in cultured smooth muscle through the activation of IGF-1 (show IGF1 Proteins) receptor and ILK overexpression

  5. our data suggest an essential role of PINCH1 (show LIMS1 Proteins), ILK and ILKAP (show ILKAP Proteins) for the radioresistance of p53 (show TP53 Proteins)-wildtype glioblastoma multiforme cells

  6. ILK inhibition and knockdown effects senescence in an Rb-dependent manner.

  7. ILK may have an important role in the progression of NSCLC, possibly through up-regulation of Snail (show SNAI1 Proteins) and MRP1 (show MDM4 Proteins).

  8. integrin linked kinase may play a role in cell proliferation, and cell migration in aggressive thyroid cancers.

  9. knockdown of ILK inhibits glioma cell migration, invasion and proliferation through upregulation of E-cadherin (show CDH1 Proteins) and downregulation of cyclin D1 (show CCND1 Proteins). Our results suggest that ILK may serve as a promising therapeutic target for glioma.

  10. Overexpression of CD29 (show ITGB1 Proteins) decreased E-cadherin (show CDH1 Proteins), but increased fibronectin (show FN1 Proteins), vimentin (show VIM Proteins), ILK activity.

Cow (Bovine) Integrin-Linked Kinase (ILK) interaction partners

  1. Integrin-linked kinase (ILK, MGC129022) is an important regulator of the endothelial phenotype and vascular network formation by directing the assembly and/or maturation of alpha5beta1-competent matrix-forming adhesions.

  2. Rac1 only partially restores the spreading defects of integrin linked kinasse (ILK)-depleted cells, suggesting that an additional ILK-dependent signal is required for cell spreading.

  3. Profilin (show PFN1 Proteins)-dependent dissociation of G-actin (show ACTB Proteins)-Tbeta4 complexes simultaneously liberates actin for filament assembly and facilitates Tbeta4 binding to integrin-linked kinase (ILK) in the lamellipodia.

Integrin-Linked Kinase (ILK) Protein Profile

Protein Summary

Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with Integrin-Linked Kinase Proteins (ILK)

  • Integrin linked kinase (Ilk)
  • integrin-linked kinase (ILK)
  • integrin-linked kinase (ilk)
  • integrin-linked protein kinase (CpipJ_CPIJ016644)
  • integrin-linked kinase (Bm1_20815)
  • integrin-linked protein kinase (Tsp_07213)
  • integrin-linked protein kinase (Tsp_07224)
  • integrin-linked protein kinase (Tsp_15354)
  • Integrin-linked protein kinase (ilk)
  • integrin linked kinase (Ilk)
  • integrin linked kinase (ilk)
  • integrin-linked kinase (Ilk)
  • AA511515 protein
  • CG10504 protein
  • CT29478 protein
  • Dmel\\CG10504 protein
  • DmILK protein
  • ESTM24 protein
  • ilk protein
  • ILK-1 protein
  • ILK-2 protein
  • l(3)78Ca protein
  • P59 protein
  • p59ILK protein
  • zgc:65842 protein

Protein level used designations for Integrin-Linked Kinase Proteins (ILK)

CG10504-PA , CG10504-PB , Ilk-PA , Ilk-PB , Integrin-linked kinase , integrin linked kinase , integrin-linked protein kinase , integrin-linked kinase , Integrin-linked protein kinase , integrin binding protein kinase , loc , lost-contact , main squeeze , msq , zilk , beta-integrin-linked kinase , 59 kDa serine/threonine-protein kinase , integrin-linked kinase-2

GENE ID SPECIES
53573 Drosophila melanogaster
374018 Gallus gallus
446640 Xenopus laevis
709944 Macaca mulatta
6050160 Culex quinquefasciatus
6099066 Brugia malayi
10898169 Trichinella spiralis
10898276 Trichinella spiralis
10910217 Trichinella spiralis
100145644 Xenopus (Silurana) tropicalis
100194973 Salmo salar
16202 Mus musculus
393543 Danio rerio
100135559 Cavia porcellus
3611 Homo sapiens
170922 Rattus norvegicus
540207 Bos taurus
100173674 Pongo abelii
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